九州大学 · 医学
Kato教授の研究室は、がん関連タンパク質の翻訳後修飾と細胞内シグナル伝達のメカニズムを解明する一方で、子宮内膜の間葉幹細胞やがん幹細胞の機能・特性にも焦点を当てています。特に、Rasオノコゲンのプロセシング機構や、子宮内膜の受容態反応に寄与する幹細胞の役割を分子・細胞生物学的手法を用いて解明しています。また、がん幹細胞に対する新規薬剤の作用機構についても革新的な知見を提供しています。
Figures are computed from collected data and may differ slightly.
We have introduced a variety of amino acid substitutions into carboxyl-terminal CA1A2X sequence (C = cysteine; A = aliphatic; X = any amino acid) of the oncogenic [Val12]Ki-Ras4B protein to identify the amino acids that permit Ras processing (isoprenylation, proteolysis, and carboxyl methylation), membrane association, and transformation in cultured mammalian cells. While all substitutions were tolerated at the A1 position, substitutions at A2 and X reduced transforming activity. The A2 residue
SP cells in the human endometrium can function as progenitor cells. This is the first report of the phenotype of SP cells from normal human endometrial cells.
This is the first report of an inhibitory effect of salinomycin on the properties of endometrial CSCs.
Successful assisted reproductive technology pregnancy depends on the viability of embryos and endometrial receptivity. However, the literature has neglected effects of the endometrial environment during the proliferative phase on implantation success or failure. Human endometrial stromal cells (hESCs) were isolated from endometrial tissues sampled at oocyte retrieval during the proliferative phase from women undergoing infertility treatment. Primary hESC cultures were used to investigate the rel
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