박경일 교수
Kyung Il Park
서울대학교 · 의학
연구실 소개
박경일 교수의 연구실은 심혈관계 질환, 특히 혈색소 변동성이 고혈압 발생에 미치는 영향을 중심으로 한 인구기반 코hort 연구를 수행하고 있습니다. 또한 해양 생물, 특히 막대조개의 집단적 폐사 원인으로서의 퍼킨수스 기생충의 역할을 분석하며 생물학적 병원체의 영향과 생태계에 미치는 영향을 연구하고 있습니다. 심장 기능의 정상적 변화 양상과 압력 또는 용적 과부하 상태에서의 심실 수축기 기능 평가 기준을 마련하는 데에도 기여하고 있습니다. 이처럼 임상의학과 생태학을 융합한 다학제적 연구가 특징입니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15URL: http://www.clinicaltrials.gov. Unique identifier: NCT01366404.
Mass mortality of the Manila clam, Ruditapes philippinarum has been reported all along the west and south coast of Korea for the past several years. As a pathogenic agent, Perkinsus sp., an endoparasitic protozoan has been identified in this study and believed to be responsible for the mass mortalities. Prevalence and infection intensity of Perkinsus sp. was investigated from a Manila clam population inhabiting at Komsoe Bay in the west coast where mass mortality of the clam has been reported. A
URL: https://www.clinicaltrials.gov. Unique identifier: NCT02618733.
ClinicalTrials.gov Identifier: NCT02193971.
Hemoglobin level determines blood viscosity and as hemoglobin level rises, blood pressure rises. However, hemoglobin level in individuals is not fixed and change in hemoglobin is affected by various clinical conditions. The purpose of this study is to investigate whether the hemoglobin variability affects the development of hypertension using Korean cohort database. This study was conducted with 94,798 adults (age ≥ 40 years) who visited the health screening in 2006 or 2007 (index year) and had
The results of this study provide normal reference values for LV-FSmw and stress-corrected LV-FSmw and their natural physiological changes with advancing age. These measures can be used as reference standards for research on LV systolic function in the setting of pressure or volume overload.
The PES was inferior to the SES in the clinical follow-up of more than 9000 patients' cohort for 5 years, which was mainly driven by the difference in the first year. In the subpopulation of people with diabetes that showed higher MACE than people without diabetes, however, PES was comparable to SES in any clinical outcome for 5 years. Although these 2 stents are not frequently used as before, the data would be useful to expect the long-term clinical course of the current DES.
In the present study, treatment with the maximal tolerated dose of valsartan did not exhibit a superior effect on post-MI LV remodelling compared with low-dose treatment and was associated with a greater frequency of adverse effect in Korean patients. Further study with a sufficient number of cases and statistical power is warranted to verify the findings of the present study.
In patients with severe AS, increased LVWT was associated with a higher AVR surgery rate and an increased rate of cardiovascular death independent of other well-known prognostic variates. Thus, these findings suggest that increased LVWT might be used as a potential prognostic factor in severe AS patients.
Cardiac troponins are associated with increased mortality, even among patients with no coronary artery disease. Elevated cardiac troponin levels are frequently observed in patients without significant coronary lesions, although the mechanism underlying this finding is unclear. The aim of our study was to evaluate the association between the levels of cardiac troponin and coronary flow reserve (CFR).We evaluated serum cardiac troponin-I in 19 patients (9 female; age 61.9±10.9 year-old). All patie
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