東北大学 · 医学
岡田教授の研究室は、がんの血管新生メカニズムに注目し、腫瘍細胞とマクロファージの相互作用が腫瘍血管形成に果たす役割を解明しています。特に、MCP-1/CCR2シグナル伝達とVEGFの発現が腫瘍微小環境内での血管新生を促進するメカニズムを、臨床標本を用いた解析によって明らかにしてきました。また、生体適合性材料の開発を通じて、がん治療のためのリアルな血流シミュレーションに適した組織代替材料の開発も進めています。
Figures are computed from collected data and may differ slightly.
Tumor angiogenesis requires the production of angiogenic factors by tumor and stromal cells. Macrophages are key effectors of angiogenesis and reported to contribute to tumor angiogenesis in several carcinomas. To investigate interactions between tumor cells and macrophages in angiogenesis, we examined macrophage infiltration, tumor vascularity and expression of monocyte chemoattractant protein (MCP)-1, CC chemokine receptor 2 (CCR2) and vascular endothelial growth factor (VEGF) in 57 archival s
The purpose of this study was to investigate the role of interactions between tumor cells and macrophages during angiogenesis in human gastric carcinomas. Macrophage infiltration into tumors and monocyte chemoattractant protein-1 (MCP-1) expression was assessed in 72 archival specimens of gastric carcinoma for comparison with tumor vascularity. The mRNA expression of MCP-1 was examined by RT-PCR in 6 gastric carcinoma cell lines and in fresh biopsy specimens from 18 patients. Immunolocalization
Did the 1973 and 1979 gasoline price rises change consumer views about the relative quality of different cars? This question is investigated by testing the null hypothesis that imputed characteristic prices have re- mained constant over time. A hedonic model that takes gasoline costs into account is developed and some of its theoretical implications are outlined.
Both model types were transparent and compatible with current medical imaging methods. PVA-H models exhibited much lower friction characteristics. PVA-H stiffness was closer to soft tissue when compared to silicone, allowing for pulsations during flow simulations.
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