大阪大学 · 医学
山崎誠教授の研究室は、消化器がん、特に食道がんや大腸がんの治療抵抗性や転移メカニズムの分子機構を解明することを主眼としています。特に、抗がん薬感受性に関与する膜タンパク質（例：MRP2）や治療後の予後予測のバイオマーカーとしてのリンパ節反応の意義を、遺伝子発現プロファイルや臨床的解析を用いて研究しています。近年の研究では、化学療法の有効性や再発・転移の予後因子に関する知見を提供しており、がん治療の個別化に貢献しています。
Figures are computed from collected data and may differ slightly.
Our data suggested that MRP2 is one of molecules, which regulate the sensitivity to chemotherapy including CDDP in advanced ESCC patients.
DCF was tolerable and effective for advanced and recurrent ESCC. Such findings might encourage a change in the treatment strategy for ESCC.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProcarboxypeptidase A-S6.* Further Studies of its Isolation and PropertiesMakoto Yamasaki, James R. Brown, David J. Cox, Roderick N. Greenshields, Roger D. Wade, and Hans NeurathCite this: Biochemistry 1963, 2, 4, 859–866Publication Date (Print):July 1, 1963Publication History Published online1 May 2002Published inissue 1 July 1963https://pubs.acs.org/doi/10.1021/bi00904a039https://doi.org/10.1021/bi00904a039research-articleACS PublicationsRequest reus
The major cause of death in colorectal cancer is related to liver metastasis. Although the metastatic process has been well studied, many aspects of the molecular genetic basis of metastasis remain unclear. Elucidation of the molecular nature of liver metastasis is urgent to improve the outcome of colorectal cancer. We analyzed the chronological gene expression profiles of 104 colorectal samples corresponding to oncogenic development including normal mucosa, localized and metastasized primary tu
The LN response to NACT predicted long-term survival more precisely than the PT response in patients with metastatic EC.
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