名古屋大学 · 医学
本研究室は、精神疾患、特に統合症に対する非薬物的介入の有効性とそのメカニズムを、臨床的・疫学的・遺伝的視点から総合的に解明することを目的としています。運動が睡眠の質を改善する可能性を示す臨床試験や、認知機能評価（WCSTなど）を用いた神経心理学的分析が進められており、特に日本集団における遺伝的要因（NETO1）の影響についても精密に検証しています。また、診断的有用性の評価に役立つ統計的手法（CAST-HSROC）の開発や、システマティックレビューにおける証拠の信頼性評価支援ツールの開発も行っています。
Figures are computed from collected data and may differ slightly.
Our findings suggest that exercise can improve sleep quality without notable adverse effects. Most trials had a high risk of selection bias. Higher quality research is needed.
UMIN000032685.
Age, education years, PANSS negative scale score and duration of illness affected WCST factor scores in patients with schizophrenia. Using WCST factor scores may reduce the possibility of type I errors due to multiple comparisons.
We did not detect evidence for the association of NETO1 with schizophrenia in the Japanese population. Common variants within the NETO1 locus may not increase the genetic risk for schizophrenia in the Japanese population. Additionally, common variants investigated in the current study did not affect cognitive performance, as measured by the CPT and WCST.
UMIN000038981 .
CAST-HSROC can easily calculate the point estimate of either sensitivity or specificity and its 95% CrI for a fixed specificity or sensitivity value on the HSROC model. The application can help to create an SoF table for DTA when systematic reviewers or guideline developers estimate the certainty of evidence on the HSROC model.
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