김민수 교수

The role of O2 free radicals in the reduction of sarcolemmal Na+-K+-ATPase, which occurs during reperfusion of ischemic heart, was examined in isolated guinea pig heart using exogenous scavengers of O2 radicals and an inhibitor of xanthine oxidase. Ischemia and reperfusion reduced Na+-K+-ATPase activity and specific [3H]ouabain binding to the enzyme in ventricular muscle homogenates and also markedly lowered sodium pump activity estimated from ouabain-sensitive 86Rb+ uptake by ventricular muscle

Process simulation using mathematical modeling tools is becoming more common in the pharmaceutical industry. A mechanistic model is a mathematical modeling tool that can enhance process understanding, reduce experimentation cost and improve product quality. A commonly used mechanistic modeling approach for powder is the discrete element method (DEM). Most pharmaceutical materials have powder or granular material. Therefore, DEM might be widely applied in the pharmaceutical industry. This review

It has been long believed that a total mode conversion between longitudinal and shear elastic waves can only be achieved at a certain incidence angle. Here, we show that a total mode conversion can be achieved for a broad range of incidence angles by a specially designed elastic metasurface, namely, transmodal metasurface. From the generalized reflection law, we found that the incident longitudinal wave can be totally converted to a reflected shear wave over a broad range of incidence angles if

Abstract Numerical simulation of fluid flow with moving free surface has been performed. For the free surface flow, a volume of fluid (VOF)‐based algorithm utilizing a fixed grid system has been investigated. In order to reduce numerical smearing at the free surface represented on a fixed grid system, a new free surface‐tracking algorithm based on the donor–acceptor scheme has been proposed. Novel features of the proposed algorithm are characterized by two numerical tools; the orientation vector