김상화 교수
Sang Wha Kim
서울대학교 · 의학
연구실 소개
김상화 교수의 연구실은 복합성 상처 치유 및 유전자 기반 재생의료 분야에서 핵심적인 연구를 수행하고 있습니다. 특히 지방줄기세포를 활용한 상처 치유 촉진, 난치성 상처 및 감염성 두개부 결손의 재건 수술, 그리고 혈관 합병증의 진단 및 치료 전략 개발에 중점을 두고 있습니다. 다양한 치료 방법의 비교 및 최적화를 통해 임상적 결과를 향상시키는 데 목적이 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15Scars vary from mature linear scars to abnormal excessive scars such as hypertrophic scars and keloid scars. Keloid scars are fibro-proliferative disease entities that reflect an abnormal process of wound healing. They can cause pain, itching, stiffness, and psychological distress, all of which can affect quality of life. Various treatment options have been advocated as ways to prevent and treat keloid scars. These include noninvasive treatments such as use of silicone gel sheeting and compressi
Impaired wound healing is a significant medical problem. Recently, cell-based therapy focused on stem cells has been developed to overcome the challenges of defective wound healing. In this study, we aimed to evaluate the effectiveness of adipose-derived stem cells (ASCs) in promoting wound healing, using different techniques for administering them. Dorsal full-thickness skin defects (1 × 1 cm) were created in three groups of mice that received intravenous ASCs by intravenous injection, intramus
Therapeutic, IV.
In this study, we compared outcomes in patients with acute hand injury, who were managed with or without negative pressure wound therapy (NPWT) after reconstructive surgery. All of the patients who sustained acute and multitissue injuries of the hand were identified. After reconstructive surgery, a conventional dressing was applied in Group 1 and NPWT was applied in Group 2. The dressing and NPWT were changed every 3 days. The mean age and Hand Injury Severity Scoring System score of both groups
Pseudoaneurysm of the superficial temporal artery is an unusual complication. Diagnosis is based on clinical findings and radiologic study. The standard treatment is surgical ligation and resection, and other treatment options include radiologic intervention, thrombin injection, and conservative treatment. In this article, the authors report several cases of pseudoaneurysm and suggest a treatment protocol to manage pseudoaneurysm of the superficial temporal artery.We conducted a retrospective re
In severe, infected scalp defects, locally available tissues are not sufficient for reconstruction and are often unhealthy. In this situation, healthy free tissue transfer offers abundant vascularity of uncompromised tissue that can control infections and a single-stage reconstruction. Between March 2002 and May 2010, 18 patients (20 cases) underwent traumatic scalp defect reconstruction with coincident infections as follows: 16 cases of postcranioplasty infections with previous traumatic open s
Reconstruction of the lateral malleolus or calcaneus region is challenging because of poor vascularity, minimal presence of soft tissue, and difficulties with flap positioning during and after the operation. In many cases, local flaps are limited in terms of size, durability, and vascularity. Free tissue transfer can be useful for complicated wounds. We report here on the results of the reconstruction in this region using free thoracodorsal artery perforator flaps. Between October 2010 and Octob
The gluteal fold V-Y advancement flap is a good option for the reconstruction of a vulvovaginal defect because it is thin, sensate, reliable, and has matched local skin quality. However, in situations where wider and deeper vulvovaginal reconstruction is needed, advancement of the flap alone may not be sufficient to create tension-free closure. To overcome these limitations, we designed a modified gluteal V-Y advancement flap, which has 1 or 2 additional transposition flaps at the base of the co
The TDAp chimeric flaps including LD or SA muscle flaps were useful for covering the vascular pedicle and relieved vascular compression during lower extremity reconstruction. © 2015 Wiley Periodicals, Inc. Microsurgery, 38:46-50, 2018..
The ulnar artery perforator flap is thin and pliable and provides nonhairy skin with color and texture matches. In addition, it is a simple and fast procedure with a reliable and constant blood supply. The ulnar artery perforator flap could be an alternative for the resurfacing of finger defects.
The TDAP chimeric flap may be another option for the complicated and complex wound coverage required to reconstruct diabetic lower leg and foot soft tissue defects.
Abstract Introduction Fibrin sealants have had applications in hemostasis, cohesion, and promotion of healing in plastic surgery. In this article, we review cases where fibrin sealant was used to stabilize microvascular pedicles and compared with previous free flaps performed without fibrin sealant. Methods Between 2008 and 2010, 62 consecutive patients underwent free tissue transfer for reconstruction; this involved 33 latissimus dorsi perforator flaps, 14 thoracodorsal artery perforator flaps,
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