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권성근 교수

Seong Keun Kwon

서울대학교 · 의학

연구실 소개

권성근 교수의 연구실은 뇌신경·소리기능 회복을 위한 첨단 재생의료 기술 개발에 초점을 맞추고 있습니다. 특히 음성 및 기도 기능을 회복하기 위한 조직공학적 솔루션, 예를 들어 음성판 재생, 기도 보존 수술, 구강 궤양 치료를 위한 세포시트 기반 치료법 개발에 주력하고 있습니다. 고도로 유연하고 생체적합성이 뛰어난 생체소재(예: 하이드로젤, 생분해성 스크래치)를 활용해 실제 조직의 기계적 특성과 기능을 재현하는 데 중점을 두고 있습니다.

음성판 재생조직공학생분해성 스크래치하이드로젤소리기능 회복

연구 현황

논문 수
143
총 인용 수
2,451
최근 5년 논문
43
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
43총합
2021
2022
2023
2024
2025
5개년 연도별 피인용 수
142총합
20212022202320242025

주요 논문

15
1
논문|인용수 131·2019
Chitosan oral patches inspired by mussel adhesion
Ji Hyun Ryu, Ji Suk Choi, Eunsook Park, Min Rye Eom, Seongyeon Jo, Moon Sue Lee, Seong Keun Kwon, Haeshin Lee
SJR Q1FWCI 4.6Journal of Controlled Release
Surfaces, Coatings and FilmsMaterials Science
2
논문|인용수 62·2019
Gelatin-based micro-hydrogel carrying genetically engineered human endothelial cells for neovascularization
Young Hwan Choi, Su‐Hwan Kim, In-Seon Kim, Kyung‐Min Kim, Seong Keun Kwon, Nathaniel S. Hwang
SJR Q1FWCI 3.1Acta Biomaterialia
Biomedical EngineeringEngineering
3
논문|인용수 42·2016
Effect of Goggle Slippage on the Video Head Impulse Test Outcome and Its Mechanisms
Myung‐Whan Suh, Jae‐Hong Park, Seong Il Kang, Jae Hyun Lim, Moo Kyun Park, Seong Keun Kwon
SJR Q1FWCI 2.4Otology & Neurotology

Slippage-induced artifacts are presumed to be because of the slingshot-like movement of the goggles during head movement in three different phases (lagging, overshooting, and bouncing of the goggles). Monitoring the pressure of the strap tightness may be a solution for minimizing this slippage. A strap tightness of at least 45 cm H2O is required for reliable vHIT recording and gain calculations.

NeurologyNeuroscience
4
논문|인용수 36·2016
Treatment of chemically induced oral ulcer using adipose‐derived mesenchymal stem cell sheet
Doh Young Lee, Hee‐Bok Kim, In Kyoung Shim, Nobuo Kanai, Teruo Okano, Seong Keun Kwon
SJR Q1FWCI 1.6Journal of Oral Pathology and Medicine

Cell sheet technology using MSC can be an alternative treatment for oral ulcerations in that it can decrease healing time without invasive properties.

GeneticsMedicine
5
논문|인용수 33·2011
Tracheal reconstruction by mesenchymal stem cells with small intestine submucosa in rabbits
Xiao Fei Du, Seong Keun Kwon, Jae‐Jun Song, Chang Gun Cho, Seok-Won Park
SJR Q2FWCI 2.7International Journal of Pediatric Otorhinolaryngology
SurgeryMedicine
6
논문|인용수 32·2014
Vocal Fold Augmentation with Injectable Polycaprolactone Microspheres/Pluronic F127 Hydrogel: Long-Term In Vivo Study for the Treatment of Glottal Insufficiency
Seong Keun Kwon, Hee-Bok Kim, Jae‐Jun Song, Chang Gun Cho, Seok-Won Park, Jong-Sun Choi, Junsun Ryu, Se Heang Oh, Jin Ho Lee
SJR Q1FWCI 9.6PLoS ONEOA

There is increasing demand for reconstruction of glottal insufficiency. Several injection materials have been examined for this purpose, but all had limitations, such as poor long-term durability, migration from the injection site, inflammation, granuloma formation, and interference with vocal fold vibration due to viscoelastic mismatch. Here, we developed a novel injection material, consisting of polycaprolactone (PCL) microspheres, which exhibits better viscoelasticity than conventional materi

Speech and HearingHealth Professions
7
논문|인용수 30·2020
Dexamethasone loaded bilayered 3D tubular scaffold reduces restenosis at the anastomotic site of tracheal replacement: <i>in vitro</i> and <i>in vivo</i> assessments
Sang Jin Lee, Ji Suk Choi, Min Rye Eom, Ha Hyeon Jo, Il Keun Kwon, Seong Keun Kwon, Su A Park
SJR Q1FWCI 2.4Nanoscale

Despite recent developments in the tracheal tissue engineering field, the creation of a patient specific substitute possessing both appropriate mechanical and biointerfacial properties remains challenging. Most tracheal replacement therapies fail due to restenosis at the anastomosis site. In this study, we designed a robust, biodegradable, 3D tubular scaffold by combining electrospinning (ELSP) and 3D (three-dimensional) printing techniques for use in transplantation therapy. After that, we load

Pulmonary and Respiratory MedicineMedicine
8
논문|인용수 28·2018
Self-Healing and Adhesive Artificial Tissue Implant for Voice Recovery
Seunghun S. Lee, Hwan Kim, Seung Hyun L. Kim, Inseon Kim, In Gul Kim, Ji Suk Choi, Jiwoon Jeong, Jung Hun Kim, Seong Keun Kwon, Nathaniel S. Hwang
SJR Q1FWCI 1.8ACS Applied Bio Materials

Loss of voice after vocal fold resection due to laryngeal cancer is a significant problem resulting in a low quality of life. Although there were many attempts to achieve a functional restoration of voice, challenges to regenerate vocal fold still remain due to its unique tissue mechanical characteristics such as pliability that produces phonation via vibration. In this study, we developed a mechanically compliant interpenetrating polymer network (IPN) hydrogel based on polyacrylamide (PAAM) and

PhysiologyMedicine
9
논문|인용수 27·2015
Segmental tracheal reconstruction by 3D-printed scaffold: Pivotal role of asymmetrically porous membrane
Doh Young Lee, Su A Park, Sang Jin Lee, Tae Ho Kim, Se Heang Oh, Jin Ho Lee, Seong Keun Kwon
SJR Q1FWCI 1.9The Laryngoscope

NA. Laryngoscope, 126:E304-E309, 2016.

Pulmonary and Respiratory MedicineMedicine
10
논문|인용수 25·2019
Injectable basic fibroblast growth factor-loaded alginate/hyaluronic acid hydrogel for rejuvenation of geriatric larynx
Young Hwan Choi, Sae Hyun Kim, In Gul Kim, Jin Ho Lee, Seong Keun Kwon
SJR Q1FWCI 2.1Acta Biomaterialia
PhysiologyMedicine
11
논문|인용수 25·2015
Synergistic effect of laminin and mesenchymal stem cells on tracheal mucosal regeneration
Doh Young Lee, Jin Ho Lee, Hee-Jin Ahn, Se Heang Oh, Tae Ho Kim, Hee-Bok Kim, Seok-Won Park, Seong Keun Kwon
SJR Q1FWCI 1.7Biomaterials
Pulmonary and Respiratory MedicineMedicine
12
논문|인용수 23·2013
Polycaprolactone spheres and theromosensitive pluronic F127 hydrogel for vocal fold augmentation: In vivo animal study for the treatment of unilateral vocal fold palsy
Seong Keun Kwon, Jae‐Jun Song, Chang Gun Cho, S.-H. Park, Soo Jung Choi, Se Heang Oh, Jin Ho Lee
SJR Q1FWCI 1.9The Laryngoscope

Locally injected PCL/Pluronic F127 can enhance glottal contact, suggesting it as a potential new therapeutic approach that may lead to better treatment of vocal fold palsy.

Pulmonary and Respiratory MedicineMedicine
13
논문|인용수 23·2013
Tracheal reconstruction with asymmetrically porous polycaprolactone/pluronic F127 membranes
Seong Keun Kwon, Jae‐Jun Song, Chang Gun Cho, Seok-Won Park, Jin Rae Kim, Se Heang Oh, Jin Ho Lee
SJR Q1FWCI 1.7Head & Neck

Off-the-shelf use of APM for tracheal reconstruction seems to be a promising strategy in the treatment of tracheal defects.

Pulmonary and Respiratory MedicineMedicine
14
논문|인용수 19·2013
Treatment of intraoral ranulas with micromarsupialization: Clinical outcomes and safety from a phase II clinical trial
Seung Hoon Woo, Jun Hyuk, Bo Hae Kim, Seong Keun Kwon
SJR Q1FWCI 2.7Head & NeckOA

Micromarsupialization can be a very effective and safe approach as an initial treatment for intraoral ranula.

Oral SurgeryDentistry
15
논문|인용수 19·2018
Characterization of the biomechanical properties of canine trachea using a customized 3D-printed apparatus
Jennifer Sang-jee Lee, Jennifer Sang-jee Lee, Jonghyun Park, Dong Ah Shin, Yoon-Jong Ryu, Hee Chan Kim, Jung Chan Lee, Jung Chan Lee, Seong Keun Kwon
SJR Q2FWCI 2.0Auris Nasus Larynx
Pulmonary and Respiratory MedicineMedicine

대표 연구 분야

Pulmonary and Respiratory MedicineSurgeryPhysiologyOtorhinolaryngologyGeneticsRadiology, Nuclear Medicine and Imaging

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