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정소이 교수

Soie Chung

서울대학교 · 의학

연구실 소개

정소이 교수의 연구실은 내과 및 임상생물학 분야에서 진단 생물학과 대사질환, 특히 당뇨병, 고지혈증, 간염 백신 반응 등에 영향을 미치는 유전적 요인과 생화학적 지표의 상관관계를 중심으로 연구를 진행하고 있습니다. 특히 LDL 콜레스테롤 추정 방법론의 정교화와 함께, HLA 유전자 다형성이 백신 면역 반응에 미치는 영향에 대한 유전학적 분석도 핵심 과제로 삼고 있습니다. 또한, 미생물 감염의 진단에 있어 전통적 배양법의 한계를 극복하기 위한 분자진단 기법의 응용도 활발히 연구되고 있습니다.

LDL 콜레스테롤 추정HLA-DPB1백신 반응 유전적 요법P. acnes 감염16S rRNA 유전자 시퀀싱

연구 현황

논문 수
36
총 인용 수
645
최근 5년 논문
7
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
7총합
2020
2022
2023
2024
2025
5개년 연도별 피인용 수
68총합
20202022202320242025

주요 논문

15
1
논문|인용수 164·2004
Common genetic polymorphisms in the promoter of resistin gene are major determinants of plasma resistin concentrations in humans
Young‐Man Cho, B.-S. Youn, Soie Chung, Ki Woo Kim, H. K. Lee, K. Yu, H. J. Park, Hyoung Doo Shin, Kyong Soo Park
SJR Q1FWCI 5.7DiabetologiaOA
EpidemiologyMedicine
2
논문|인용수 110·2008
A mitochondrial DNA variant at position 16189 is associated with type 2 diabetes mellitus in Asians
Kyong Soo Park, Juliana C.N. Chan, Lee‐Ming Chuang, Susumu Suzuki, Eiichi Araki, K Nanjo, Ji Liang, Maggie Ng, Masahiro Nishi, Hiroto Furuta, T. Shirotani, Byung Yong Ahn
SJR Q1FWCI 3.6DiabetologiaOA
Molecular BiologyBiochemistry, Genetics and Molecular Biology
3
erratum|인용수 52·2004
Erratum to: Common genetic polymorphisms in the promoter of resistin gene are major determinants of plasma resistin concentrations in humans
Young‐Man Cho, Byung‐Soo Youn, Soie Chung, Ki Woo Kim, H. K. Lee, Kern-Ho Yu, H. J. Park, H. D. Shin, Kyong Soo Park
SJR Q1FWCI 3.4DiabetologiaOA
EpidemiologyMedicine
4
논문|인용수 44·2005
Regulation of human resistin gene expression in cell systems: an important role of stimulatory protein 1 interaction with a common promoter polymorphic site
Soie Chung, HyeJi Choi, Ki Woo Kim, Young‐Man Cho, H. K. Lee, Kyong Soo Park
SJR Q1FWCI 3.2DiabetologiaOA
EpidemiologyMedicine
5
논문|인용수 26·2011
Neutrophil and monocyte activation markers have prognostic impact in disseminated intravascular coagulation: In vitro effect of thrombin on monocyte CD163 shedding
Soie Chung, Ji‐Eun Kim, Seungman Park, Kyou Sup Han, Hyun Kyung Kim
SJR Q2FWCI 1.4Thrombosis Research
EpidemiologyMedicine
6
논문|인용수 22·2019
HbA1c showed a positive association with carcinoembryonic antigen (CEA) level in only diabetes, not prediabetic or normal individuals
Soie Chung, Yunhwan Lee, Eun Youn Roh
SJR Q1FWCI 1.4Journal of Clinical Laboratory AnalysisOA

In diabetes, the CEA level was independently and positively correlated with glycemic control status. Additionally, the change in CEA level (delta CEA) showed a positive correlation with the change in HbA1c level (delta HbA1c) in the follow-up data analysis.

Endocrinology, Diabetes and MetabolismMedicine
7
논문|인용수 19·2017
Usefulness of the Martin Method for Estimation of Low-Density Lipoprotein Cholesterol in Coronary Atherosclerosis
Soie Chung
SJR Q1FWCI 0.9Medical Principles and PracticeOA

The Martin method to estimate LDL-C using the strata-specific TG:VLDL ratio showed a 2-fold better concordance with LDL-C measured with a direct homogeneous assay in coronary atherosclerosis compared to the Friedewald equation when the TG level was ≥200 mg/dL. This finding suggests that MLDL could be a better alternative for estimating LDL-C compared to FLDL when the TG level is ≥200 mg/dL in coronary atherosclerosis.

Endocrinology, Diabetes and MetabolismMedicine
8
논문|인용수 18·2019
GWAS identifying <i>HLA‐DPB1</i> gene variants associated with responsiveness to hepatitis B virus vaccination in Koreans: Independent association of <i>HLA‐DPB1*04:02</i> possessing rs1042169 G ‐ rs9277355 C ‐ rs9277356 A
Soie Chung, Eun Youn Roh, Boram Park, Yunhwan Lee, Sue Shin, Jong Hyun Yoon, Eun Young Song
SJR Q2FWCI 1.3Journal of Viral Hepatitis

Recently, HLA class II loci, including HLA-DPB1, have been reported to be associated with interindividual variance in the hepatitis B (HB) vaccine response. In this study, we investigated significant single nucleotide polymorphisms (SNPs) for anti-HBs antibody levels in 6867 healthy Koreans using a genome-wide association study (GWAS). In GWAS, the top 20 SNPs that showed significant association with anti-HBs levels (P < 1.0 × 10<sup>-29</sup> ) all resided in HLA-DPB1. Utilizing PCR sequencing,

EpidemiologyMedicine
9
리뷰|인용수 17·2019
Update on low-density lipoprotein cholesterol quantification
Soie Chung
SJR Q1FWCI 1.8Current Opinion in Lipidology

For the current therapeutic goal of LDL-C values below 70 mg/dl in high-risk patients, accurate assessment of LDL-C levels at very low levels is required. Martin's method could overcome pitfalls such as underestimation of the Friedewald equation at this level. Further evaluation of the triglycerides/VLDL-C ratio in participants with diverse ethnic backgrounds or clinical conditions would expand the implementation of this novel method.

Endocrinology, Diabetes and MetabolismMedicine
10
논문|인용수 16·2011
다산 정약용의 인심·도심론
정소이

「중용장구서」에서 정약용은 주희를 높이 평가하며 이는 그의 인심도심론이 주희의 주장을 어느 정도 수용한 것이라는 막연한 추측을 낳았다. 그러나 다음의 세 가지 면에서 정약용의 인심•도심론은 주희뿐 아니라 기존의 어느 설과도 구분되는 독창적인 체계를 보여준다. 첫째 정약용이 말하는 성인의 인심은 주희가 말하는 가치중립적인 생래적 욕구가 아닌 사욕을 포함한 ‘예비 악’에 가깝다. 둘째 주희의 도심은 인심의 기준이 되는 절대적이고 순선한 가치 즉 인의예지 그 자체인 것에 반해 정약용의 도심은 인심과 맞서는 도덕적 욕망으로 사욕을 저지하고 도덕행위로 이끄는 ‘동력’은 될 수 있으나 그 자체로 완전한 덕목은 아니다. 셋째 정약용의 인심과 도심은 어느 한 쪽을 ‘굳게 잡아 선택할 수 있는’ 항목이 아니다. 그들은 끊임없는 갈등相爭 속에 있으며 어느 한 쪽도 기질이나 환경에 의해 우세하게 될 수는 없다. 정약용이 이와 같이 인심과 도심을 각기 다른 방향으로 치닫는 욕구 예비 악과 예비 선으로 설

11
논문|인용수 12·2019
False-positive Elevations in Carcinoembryonic Antigen Levels at a Health Screening Center
Soie Chung
FWCI 1.9Laboratory Medicine Online
Pulmonary and Respiratory MedicineMedicine
12
논문|인용수 12·2011
A Case of Brain Abscess Caused by Propionibacterium acnes 13 Months after Neurosurgery and Confirmed by 16S rRNA Gene Sequencing
Soie Chung, Jun-Sik Kim, Sang Won Seo, Eun Kyung, Sei-Ick Joo, So Yeon Kim, Sung Sup Park, Eui-Chong Kim
SJR Q2FWCI 0.6Annals of Laboratory MedicineOA

Propionibacterium acnes is a gram-positive anaerobic bacillus and a normal inhabitant of the skin. Although it is often considered a contaminant of blood cultures, it can occasionally cause serious infections, including postoperative central nervous system infections. Here, we report the case of a 70-yr-old man who developed a large cerebral abscess caused by P. acnes 13 months after neurosurgery. Immediate gram staining of the pus from his brain revealed the presence of gram-positive coccobacil

Clinical BiochemistryBiochemistry, Genetics and Molecular Biology
13
논문|인용수 10·2010
Circulating hepatocyte growth factor as an independent prognostic factor of disseminated intravascular coagulation
Soie Chung, Ji‐Eun Kim, Ju‐Young Kim, Dong Soon Lee, Kyou Sup Han, Hyun Kyung Kim
SJR Q2FWCI 0.3Thrombosis Research
HepatologyMedicine
14
논문|인용수 8·2012
Comparison of Modified Multiple-locus Variable-number Tandem-repeat Fingerprinting with Pulsed-field Gel Electrophoresis for Typing Clinical Isolates of Staphylococcus aureus
Soie Chung, Jongyoun Yi, Mi Hee Jang, Sei-Ick Joo, Eun Kyung, So Yeon Kim, Chulhun L. Chang, Sung Sup Park, Eui-Chong Kim
SJR Q2FWCI 0.3Annals of Laboratory MedicineOA

Our simple, low-cost, modified MLVF protocol can effectively discriminate between S. aureus clinical isolates. MLVF can replace PFGE for the hospital infection control of S. aureus.

Infectious DiseasesMedicine
15
논문|인용수 7·2013
Prevalence and Genotype of Human Papillomavirus Infection and Risk of Cervical Dysplasia among Asymptomatic Korean Women
Soie Chung, Sue Shin, Jong Hyun Yoon, Eun Youn Roh, Sung Jun Seoung, Young‐Kug Kim, Eui-Chong Kim
FWCI 0.2Annals of Clinical MicrobiologyOA

Background The persistence of infection by high-risk human papillomavirus (HPV) may lead to cervical cancer. Recently, the American Society for Colposcopy and Cervical Pathology (ASCCP) announced that on-cogenic HPV screening and the PAP smear are the main methods of screening for cervical cancer. The goal of this study was to investigate the prevalence and genotyping of HPV, as well as the risk of cervical dysplasia. Methods HPV genotyping was conducted by a com-mercial chip assay. Cervical dys

EpidemiologyMedicine

대표 연구 분야

EpidemiologySurgeryEndocrinology, Diabetes and MetabolismHematologyCardiology and Cardiovascular MedicineMolecular Biology

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