김 수 영 교수

Reminiscent of Russian Matrioshka dolls, tetraazamacrocycles (1,4,7,10-tetraazacyclododecane (cyclen) and 1 , 4 , 8 , 11 - tetraazacyclotetradecane (cyclam)) and their transition metal complexes are encapsulated in the cavity of cucurbit[8]uril (CB[8]). The X-ray crystal structure of the [Cu(cyclen)] in CB[8] complex (see picture; copper: green, oxygen: red, nitrogen: blue, carbon: gray) reveals a five-coordinate Cu^II center in a square-pyramidal environment with a water molecule boun

The protection of the brain from blood-borne toxins, proteins, and cells is critical to the brain's normal function. Accordingly, a compromise in the blood-brain barrier (BBB) function accompanies many neurologic disorders, and is tightly associated with brain inflammatory processes initiated by both infiltrating leukocytes from the blood, and activation of glial cells. Those inflammatory processes contribute to determining the severity and prognosis of numerous neurologic disorders, and can bot

Brain damage due to stroke or traumatic brain injury (TBI), both leading causes of serious long-term disability, often leads to the development of epilepsy. Patients who develop post-injury epilepsy tend to have poor functional outcomes. Emerging evidence highlights a potential role for blood-brain barrier (BBB) dysfunction in the development of post-injury epilepsy. However, common mechanisms underlying the pathological hyperexcitability are largely unknown. Here, we show that comparative trans

NSAIDs are somewhat effective in relieving the discomfort caused by a cold but there is no clear evidence of their effect in easing respiratory symptoms. The balance of benefit and harms needs to be considered when using NSAIDs for colds.

Beta-glucan is a polysaccharide in the form of fiber and the main element of fiber in grains such as barley, oats, yeast and mushrooms. Many studies have examined the efficacy of beta-glucan in terms of the lipid lowering effects, blood sugar reduction, weight reduction, immune modulator, and anticarcinogenic effect. However, there is no comprehensive review article on the biomedical issues regarding beta-glucan. The authors searched for systematic reviews and clinical experiments for each relev

Recently, three-dimensional printing (3DP) technology has been widely adopted in biology and biomedical applications, thanks to its capacity to readily construct complex 3D features. Using hot-melt extrusion 3DP, scaffolds for bone tissue engineering were fabricated using a composite of biodegradable polycaprolactone (PCL) and hydroxyapatite (HA). However, there are hardly any published reports on the application of the fused deposition modeling (FDM) method using feed filaments, which is the mo

Purpose The purpose of this paper is to suggest a conceptual model of formal mentoring as a leadership development initiative including “learning goal orientation”, “mentoring functions”, and “leadership competencies” as key constructs of the model. Design/methodology/approach Some empirical studies, though there are not many, will provide positive suggestions for the effectiveness of formal mentoring in leadership development. Then the rationale of the conceptual model will be provided with tes

Accurate business failure prediction represents an advantage for market players and is important for risk management. The purpose of this study is to develop a more accurate and stable business failure prediction model by using a majority voting ensemble method with a decision tree (DT) with experimental data on US restaurant between 1980 and 2017. According to the diversity principle and individual optimized principle, DT and logit were selected as basic learning algorithms for the voting ensem