김선미 교수
Sunmie Kim
서울대학교 · 의학
연구실 소개
김선미 교수의 연구실은 호르몬 및 대사질환과 관련된 유전적 요인과 영양소의 역할을 중심으로 연구를 진행하고 있습니다. 특히 다낭성 난소 증후군(PCOS) 환자에서 비타민 D 수치와 호르몬 상태, 대사증후군 간의 상관관계를 규명하는 데 초점을 맞추고 있으며, 난소 기능과 관련된 항미울러스호르몬(AMH)의 역할에 대해서도 심층적인 분석을 수행하고 있습니다. 또한, SARS-CoV-2 감염과 COVID-19 중증도에 영향을 미칠 수 있는 인체 유전적 요인에 대해서도 글로벌 연구 네트워크를 통해 기초 생물학적 메커니즘을 탐구하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15This study was supported by a grant of the Korea Healthcare technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI12C0055). The authors have no conflict of interest to declare.
Our study found no differences in the absolute level of serum vitamin D between PCOS patients and matched controls. Prevalence of vitamin D deficiency was equally common among both patients and controls. Additionally, we did not find any correlations between serum vitamin D level and clinical or metabolic profiles, suggesting that the role of vitamin D in the pathogenesis of PCOS is not yet clear.
Endometrial stripe abnormality is a significant factor to predict EH+ in healthy premenopausal and perimenopausal women with and without AUB. However, simple measurement of endometrial thickness has a limited role in this capacity.
Objective: To compare the outcomes of 14-gauge automated biopsy and 11-gauge vacuum-assisted biopsy for the sonographically guided core biopsies ofbreast lesions. Materials and Methods: We retrospectively reviewed all sonographically guidedcore biopsies performed from January 2002 to February 2004. The sonographicallyguided core biopsies were performed with using a 14-gauge automatedgun on 562 breast lesions or with using an 11-gauge vacuum-assisted deviceon 417 lesions. The histologic findings
Purpose: Re-excisions after breast-conserving surgery (BCS) for breast cancer cause delays in the adjuvant treatment, increased morbidity, and leads to poor aesthetic results. Thus, efforts to reduce the re-excision rate are essential. This study aimed to conclusively determine the re-excision rate and the factors associated with re-excision after BCS. Methods: We retrospectively reviewed the medical records and pathological reports of 711 cases that underwent BCS for early-stage breast cancer.
Purpose: The management of benign intraductal papilloma (IDP) without atypia diagnosed on core needle biopsy (CNB) remains controversial. This study was performed to evaluate the rate of upgrading to malignancy or high-risk lesions after excision and to identify factors associated with upgrading using a large series of benign IDP cases without atypia. Methods: We included patients who were diagnosed as having benign IDP without atypia on CNB and underwent surgical or vacuum-assisted excision bet
Our study suggests that MS may have little impact on sexual function in middle- to old-aged women. Further studies with population-based and longitudinal design should be conducted to confirm this finding.
Objective: The aim of the study was to compare the accuracy of magnetic resonance imaging (MRI) and mammography for the detection and assessment of the size of ductal carcinoma in situ (DCIS). Materials and Methods: The preoperative contrast-enhanced MRI and mammography were analyzed in respect of the detection and assessment of the size DCIS in 72 patients (age range: 30 67 years, mean age: 47 years). The MRI and mammographic measurements were compared with the histopathologic size with using t
This study was performed to compare the prevalence of autoimmune thyroid disease (AITD) assessed by thyroid peroxidase antibody (anti-TPO Ab) and thyroid ultrasonography (USG) in Korean women with polycystic ovary syndrome (PCOS) (<i>n</i> = 210) and age-matched controls (<i>n</i> =343). We also compared the clinical features of women with PCOS according to the presence of AITD. Patients and controls were enrolled from a population who visited a screening centre for a general health check-up. Th
Visfatin levels in PCOS patients were similar to those in the controls. However, hyperandrogenic patients showed significantly higher serum visfatin levels than those of non-hyperandrogenic patients, and visfatin had a positive linear correlation with FAI in both PCOS patients and controls.
Objective: We wanted to assess the need for surgical excising papillary lesions of the breast that were diagnosed upon sonographically guided 14-gauge core needle biopsy. Materials and Methods: Sixty-nine women (age range: 25 74 years, mean age: 51.7 years) with 69 papillary lesions (4.9%) were diagnosed and followed after performing sonographically guided 14-gauge core needle biopsies. Surgical excision was performed for 44 (64%) of 69 papillary lesions, and 25 lesions were followed with imagin
Among body composition parameters, only increased skeletal muscle mass had a positive correlation with increased BMD over the study period of 2.7 years.
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