京都大学 · 医学
佐藤進教授の研究室では、希土類元素を用いた発光材料のエネルギー移動メカニズムに注目し、特にイットリア系発光体やルチル系キレート錯体における三重状態から希土類イオンへのエネルギー移動の詳細を時間分解分光法を用いて解明しています。また、臨床応用としても、てんかん治療薬の有効性と副作用の比較研究を通じて、薬理学的応用の可能性を追求しています。
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Abstract The fluorescence yield of europium chelates in several solutions varies, through its maximum value, with the increase in the energy difference between the triplet state of a ligand and the emitting level of an europium ion. The time-resolved spectroscopic measurements show that the excitation energy is transferred from the triplet state to the lower and nearest resonance level of the europium ion. The intramolecular energy transfer mechanisms for europium chelates and terbium chelates a
Valproic acid (VPA) and ethosuximide (ESM) were compared in a double-blind, response- conditional crossover study of absence seizures in 16 naive (previously untreated for absence seizures) and 29 refractory patients (18 male and 27 female; 4 to 18 years of age). In the naive patients VPA was as effective as ESM in reducing generalized spike-wave discharges on the telemetered EEG. Adverse reactions to VPA or ESM were generally mild and responded to withdrawal or dosage reduction of the drug.
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