慶應義塾大学 · 化学
Mashino教授の研究室では、ナノサイズのフラーレン誘導体を用いたがん細胞への標的制御や、がん治療における薬剤耐性のメカニズム解明を主な研究テーマとしています。特に、水溶性フラーレン誘導体が白血球腫瘍細胞に与えるアポトーシス誘導作用や、p62/Nrf2シグナル伝達経路を標的にした新規抗がん剤の開発に注力しています。ROS発生やミトコンドリア機能障害を介した細胞死誘導機構の解明も進んでいます。
Figures are computed from collected data and may differ slightly.
The biological activities of C(60)-bis(N,N-dimethylpyrrolidinium iodide), a water-soluble cationic fullerene derivative, on human promyeloleukaemia (HL-60) cells were investigated. The pyrrolidinium fullerene derivative showed cytotoxicity in HL-60 cells. The characteristics of apoptosis, such as DNA fragmentation and condensation of chromatin in HL-60 cells, were observed by exposure to the pyrrolidinium fullerene derivative. Caspase-3 and -8 were activated and cytochrome c was also released fr
Resistance to anticancer agents has been an obstacle to developing therapeutics and reducing medical costs. Whereas sorafenib is used for the treatment of human hepatocellular carcinoma (HCC), resistance limits its efficacy. p62, a multifunctional protein, is overexpressed in several HCC cell lines, such as Huh-1 cells. Phosphorylated p62 (<i>p</i>-p62) inhibits the protein-protein interaction (PPI) between Keap1 and Nrf2, resulting in the Nrf2 overactivation that causes drug resistance. We have
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