이태진 교수

Systemic siRNA administration to target and treat glioblastoma, one of the most deadly cancers, requires robust and efficient delivery platform without immunogenicity. Here we report newly emerged multivalent naked RNA nanoparticle (RNP) based on pRNA 3-way-junction (3WJ) from bacteriophage phi29 to target glioblastoma cells with folate (FA) ligand and deliver siRNA for gene silencing. Systemically injected FA-pRNA-3WJ RNPs successfully targeted and delivered siRNA into brain tumor cells in mice

4-(Trimethylsiloxy)-3-pentene-2-one (TMSPO) is tested as an electrolyte additive to enhance Coulombic efficiency and cycle retention for the Li/LiNi_0.5Mn_1.5O₄ (LNMO) half-cell and graphite/LNMO full-cell. TMSPO carries two functional groups, siloxane (-Si-O-) and carbon-carbon (C═C) double bonds. It is found that the siloxane group reacts with hydrogen fluoride (HF), which is generated by hydrolysis of lithium hexafluorophosphate (LiPF₆) by impure wate

DNA replication programs have been studied extensively in yeast and animal systems, where they have been shown to correlate with gene expression and certain epigenetic modifications. Despite the conservation of core DNA replication proteins, little is known about replication programs in plants. We used flow cytometry and tiling microarrays to profile DNA replication of Arabidopsis thaliana chromosome 4 (chr4) during early, mid, and late S phase. Replication profiles for early and mid S phase wer

Wnt1-inducible signaling pathway protein-1 (WISP1) is a Cyr61/CTGF/NOV (CCN) family matricellular protein involved in adipogenesis and low-grade inflammation in obesity. However, the roles of WISP1 in hepatic steatosis and insulin resistance in skeletal muscle remain elusive. Mouse primary hepatocytes and differentiated mouse skeletal muscle cells (C2C12) were treated with various concentrations of WISP1 and the functions and signaling pathways were analyzed by Western blot analysis. In vivo tra

The aim of this study was to investigate the associations between the incidence of thyroid cancer and the characteristics of healthcare systems in OECD countries and to demonstrate that the increasing incidence of thyroid cancer is mainly due to overdiagnosis. We used a random effects panel model to regress the incidence of thyroid cancer on the characteristics of healthcare systems (i.e. , share of public expenditure on health, mode of health financing, existence of referral system to secondary

Integrin β1 receptor, expressed on the surface of tumor cells and macrophages in the tumor microenvironment (TME), has been implicated in both tumor progression and resistance to multiple modalities of therapy. OS2966 is the first clinical-ready humanized monoclonal antibody to block integrin β1 and was recently orphan designated by the FDA Office of Orphan Products Development. Here, we tested therapeutic potential of OS2966-mediated integrin β1 blockade to enhance the efficacy of oncolytic her

소득수준 향상 및 고가 의료기술의 도입에 따라 의료수요가 증가하고, 그 결과 우리나라의 의료비 지출은 현저한 증가 추세를 보이고 있다. 이러한 의료비 지출의 증가는 가구의 경제적 부담능력에 비해 많은 의료비를 지출하게 되는 “과부담” 문제를 야기하고 있다. 이에, 본 연구에서는 우리나라 의료비 지출에 대한 상세한 정보를 얻을 수 있는 한국의료패널 1차년도 자료를 이용하여, 우리나라 가구의 과부담의료비 발생 현황을 살펴보고, 가구의 사회경제적 지위에 따라 과부담의료비의 발생이 어떠한 분포를 보이는지를 확인하였다. 또한 한국의료패널의 장점을 살려, 가구원이 갖고 있는 만성질환의 종류에 따라 과부담의료비의 발생이 어떻게 다른지를 확인하고, 로지스틱 회귀분석을 실시하여 가구의 과부담의료비 발생에 영향을 주는 요인을 찾아보았다. 분석 결과, 2008년 과부담의료비 발생률은 가구 생활비의 10%를 기준으로 할 경우 19.7%, 가구소득의 10%를 기준으로 할 경우 15.7%인 것으로 나타났으며

Tris(pentafluorophenyl)silane (TPFPS) is tested as a film-forming agent for nickel-doped manganese spinel (LiNi0.5Mn1.5O4, LNMO) positive electrode. The surface film derived from the TPFPS-free electrolyte (organic carbonate-based one) is poorly passivating the high-voltage positive electrode to cause continued electrolyte oxidation and film deposition. It leads to an increase in the film resistance and thus electrode polarization eventually causing capacity fading. In contrast, the surface film

A comparative study on the passivation ability and ion transport property of two surface films was performed; one on a nickel-doped manganese spinel (LiNi0.5Mn1.5O4, LNMO) positive electrode and the other on a graphite negative electrode. The surface film on graphite is impermeable to electrolyte molecules and highly passivating; these are characteristic features of solid electrolyte interphase (SEI). In contrast, the surface film on LNMO is highly permeable to molecules and thus poorly passivat