大阪大学 · 医学
Takuro Saito教授の研究室は、消化器外科領域における治療成績の向上と患者の生活の質(QoL)の向上を目的として、胃がんや食道がんの手術的治療の最適化を研究しています。特に、術後の予後を予測するバイオマーカー(例:CRP)の意義や、機能保存的手術(例如:幽門保持胃切除術)の有効性、およびドナー臓器の限られた状況下での臓器提供(DCD由来膵島移植)の可能性についての革新的な研究が進められています。また、手術の安全性と血流評価には蛍光造影イメージング技術を応用し、最小侵襲的手術の実現に貢献しています。
Figures are computed from collected data and may differ slightly.
CRP elevation is a more reliable indicator of survival after gastric cancer surgery than postoperative complication occurrence. Surgeons should minimize the postoperative inflammatory response to improve prognosis.
Islet transplantation employing DCD can ameliorate severe hypoglycemic episodes, significantly improve HbA1c levels, sustain significant levels of C-peptide, and achieve insulin independence after multiple transplantations. Thus, DCD can be an important resource for islet transplantation if used under strict releasing criteria and in multiple transplantations, particularly in countries where heart-beating donors are not readily available.
Recent improvements in the survival of patients after esophagectomy have led to an increase in the occurrence of gastric tube cancer (GTC). Total resection of the gastric tube with lymphadenectomy is a standard and reliable treatment for GTC, but problems may arise during or after surgery, such as laryngeal nerve injury, reduced selection of organs for reconstruction, and impaired swallowing function. We recently performed a less invasive procedure, subtotal gastrectomy with preservation of the
Recent advances in diagnostic techniques have allowed the diagnosis of gastric cancer (GC) at an early stage. Due to the low incidence of lymph node metastasis and favorable prognosis in early GC, function-preserving surgery which improves postoperative quality of life may be possible. Pylorus-preserving gastrectomy (PPG) is one such function-preserving procedure, which is expected to offer advantages with regards to dumping syndrome, bile reflux gastritis, and the frequency of flatus, although
These findings indicate that the keratocytes are abnormal and inflammation is still present in the corneal stroma in the chronic phase of SJS, OCP and alkali burns.
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