九州大学 · 医学
Tomoharu Yoshizumi教授の研究室は、肝細胞癌や肝移植を対象とした臨床研究を主軸としており、特に術後予後予測や患者選択のバイオマーカーとしてのNLR（好中球対好酸球比）やサルコペニアの意義を解明しています。また、小規模肝チケット症候群のリスク要因や、ドナー安全性を考慮した左側葉摘出を伴う生体肝移植の成績検討など、臨床的意義の高い研究を精力的に行っており、患者個別のリスク評価と治療戦略の最適化を目指しています。
Figures are computed from collected data and may differ slightly.
Our results show that NLR is an independent predictor of survival after hepatectomy in patients with HCC. Accumulation of tumor-associated macrophages in the tumor is associated with a high NLR.
Small-for-size (SFS) graft syndrome is one of the major causes of graft loss in living donor liver transplantation (LDLT). We examined whether splenectomy is beneficial for overcoming SFS graft syndrome in LDLT. The patients were classified into two groups: the Sp (-) group (n=69), in which splenectomy was not performed, and the Sp (+) group (n=44), in which it was. The incidence of SFS graft syndrome was investigated. Risk factors of SFS graft syndrome were identified by univariate- and multiva
This retrospective analysis revealed that sarcopenia was predictive of worse overall survival and recurrence-free survival after hepatectomy in patients 70 years of age and older with HCC.
LDLT should not be performed for patients who have both independent risk factors after any treatments for HCC.
Donor safety is the priority when performing a living donor adult liver transplantation (LDALT). We herein present our findings using left-lobe graft in LDALT. Data on 119 recipients who underwent the LDALT, and on 119 donors who underwent extended left lobectomy were reviewed. The recipients were divided into groups above (n = 19) and below (n = 100) 50 years of donor age, into groups above (n = 63) and below (n = 56) 40% of graft size (graft volume/standard liver volume, GV/SLV), and above (n
Sarcopenia can be defined by the difference between measured data and calculated data using our new formulae.
No reliable model for predicting early graft function and patient survival after living donor liver transplantation (LDLT) exists. The aim of this study was to establish a new formula for predicting early graft function and prognosis using technetium-99m galactosyl-human serum albumin (Tc-GSA) liver scintigraphy. The ratio of the hepatic uptake ratio of Tc-GSA to the clearance index of Tc-GSA (LHL/HH) was determined 7 days after LDLT. There were 22 patients with a ratio greater than 1.3 and 6 pa
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