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The authors analyze the physical prerequisites on which the proposed stereochemical theory of the three-dimensional structure of globular proteins is based. The theory represents a stereochemical modelling of the mechanism of protein self-organization suggested earlier by one of the authors. According to this mechanism, a highly helical intermediate structure(s) is formed at first and then it passes into the native one. In the highly-helical intermediate structure the arrangement of the polypept

It is shown within the framework of stereochemical modeling that disruption of water shells of proteins and nucleic acids is confronted by significant kinetic barriers caused by the breaking of hydrogen bonds. The structure of the water shells is dictated by the surface of proteins and nucleic acids, therefore the kinetic barriers due to disruption of the water shell are strongly distinct from each other on different parts of the shell. This, in turn, means that the probability of participation

Abstract Hamlet’s ‘To be or not to be’ speech has long been the subject of intense scholarly attention. By situating the speech against the backdrop of classical and Renaissance rhetorical theory, this essay demonstrates that there is still much more to be said about it. The speech ostensibly examines a quaestio infinita or a thesis, and follows the rhetorical rule that the right way to do so is by the invocation of commonplaces. This reading of Hamlet’s speech is not only consistent with Shakes

Ivan Lupić;. Subjects of Advice: Drama and Counsel from More to Shakespeare Ivan Lupić. Subjects of Advice: Drama and Counsel from More to Shakespeare. Pp. 260. Philadelphia: University of Pennsylvania Press, 2019. Hardback, £48.00. Vanessa Lim Vanessa Lim Maynooth University, IrelandInstitute of English Studies, University of London, UK E-mail: vanessa.lim@mu.ie Search for other works by this author on: Oxford Academic Google Scholar The Review of English Studies, Volume 72, Issue 306, Septembe