Yonsei University · 医学
Professor Won Gil Cho's research lab specializes in vascular biology, neurodegeneration, and anti-inflammatory therapeutics, with a focus on the molecular mechanisms underlying angiogenesis, hypoxia-induced cell death, and innate immune responses. The lab investigates key regulators such as Toll-like receptor 3 (TLR3), chemokines like CCL11, and endogenous pathways involving reactive oxygen species (ROS) and gasdermin activation in disease contexts including retinal neovascularization, asthma, and brain injury. Innovative drug delivery systems, such as curcumin-loaded PLGA microparticles, are also developed to enhance therapeutic efficacy in inflammatory and hypoxic conditions.
Figures are computed from collected data and may differ slightly.
Neovascularization in response to tissue injury consists of the dual invasion of blood (hemangiogenesis) and lymphatic (lymphangiogenesis) vessels. We reported recently that 21-nt or longer small interfering RNAs (siRNAs) can suppress hemangiogenesis in mouse models of choroidal neovascularization and dermal wound healing independently of RNA interference by directly activating Toll-like receptor 3 (TLR3), a double-stranded RNA immune receptor, on the cell surface of blood endothelial cells. Her
CCR3, the receptor for CCL11, is expressed on the surface of immune cells and even on non-immune cells. CCL11-CCR3 interactions can promote cell migration and proliferation. In this study, we investigated the effect of CCL11 on angiogenesis in HUVECs and also examined the molecular mechanisms of this process. We found that CCL11 induced mRNA transcription and protein expression of CCR3 in HUVECs. Moreover, the scratch wound healing assay and MTS proliferation assay both demonstrated that CCL11 p
Curcumin is considered a potential anti-asthmatic agent owing to its anti-inflammatory properties. The objective of the present study was to prepare curcumin-containing poly(lactic-<i>co</i>-glycolic acid)-based microscale discoidal polymeric particles (Cur-PLGA-DPPs) and evaluate their anti-asthmatic properties using a murine asthma model. Cur-PLGA-DPPs were prepared using a top-down fabrication method. The prepared Cur-PLGA-DPPs had a mean particle size of 2.5 ± 0.4 μm and a zeta potential val
Hypoxia is a condition in which the whole body or a region of the body is deprived of oxygen supply. The brain is very sensitive to the lack of oxygen and cerebral hypoxia can rapidly cause severe brain damage. Astrocytes are essential for the survival and function of neurons. Therefore, protecting astrocytes against cell death is one of the main therapeutic strategies for treating hypoxia. Hence, the mechanism of hypoxia-induced astrocytic cell death should be fully elucidated. In this study, a
Hypoxia-induced neuronal death is a major cause of neurodegenerative diseases. Pyroptosis is a type of inflammatory programmed cell death mediated by elevated intracellular levels of reactive oxygen species (ROS). Therefore, we hypothesized that hypoxia-induced ROS may trigger pyroptosis via caspase-dependent gasdermin (GSDM) activation in neuronal cells. To test this, we exposed SH-SY5Y neuronal cells to cobalt chloride (CoCl<sub>2</sub>) to trigger hypoxia and then evaluated the cellular and m
Toll-like receptor 3 (TLR3) plays an important role in double-stranded RNA recognition and triggers the innate immune response by acting as a key receptor against viral infections. Intracellular reactive oxygen species (ROS) are involved in TLR3-induced inflammatory responses during viral infections; however, their relationship with mitochondrial ROS (mtROS) remains largely unknown. In this study, we show that polyinosinic-polycytidylic acid (poly(I:C)), a mimic of viral RNA, induced TLR3-mediat
최근 세계 각국은 자국의 안전, 소비자, 환경보호를 목적으로 매년 새로운 무역기술 규제를 도입하고 있어 해외시장진출 기업에게 무역기술장벽으로 작용하고 있다. WTO는 자국 규제가 무역에 불필요한 장벽이 되지 않도록 보장 권고하고 기술규정, 표준, 적합성 평가 절차 제도를 통해 생산성 향상과 세계무역에 기여해왔다. 특히 디지털기술 발전에 힘입어 디지털 인공지능이 자국의 신기술경쟁력으로 인지되면서 새로운 TBT가 부각되고 있다. 그러나 국내는 미국, EU와 여러 나라에 비해 인공지능에 대한 투자와 규제가 준비단계에 머물러 있는 실정이다. 학술적으로도 기존 제품 중심의 TBT 선행연구는 다양한 관점에서 논의되어 왔지만 인공지능 관련 TBT에 관한 연구는 많지 않은 것으로 나타났다. 따라서 본고는 인공지능이 무역기술경쟁력으로 부각되는 디지털통상시대에 맞추어 비관세장벽으로 작용할 수 있는 인공지능 관련 TBT에 대한 대응방안을 선험적으로 모색한 연구이다. 이를 위해 WTO TBT AI 관련
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