Seoul National University · 生化学・遺伝学・分子生物学
Professor Won Keun Oh's research lab specializes in natural product-based drug discovery, with a primary focus on identifying bioactive compounds from medicinal plants and marine organisms for the treatment of metabolic and neurodegenerative diseases. The lab investigates molecular mechanisms underlying metabolic regulation, particularly through key enzymes such as acetyl-CoA carboxylase 2 (ACC2), protein tyrosine phosphatase 1B (PTP1B), and AMP-activated protein kinase (AMPK). Current research directions include the development of therapeutic agents targeting type 2 diabetes, obesity, Alzheimer’s disease, and breast cancer using natural compounds with antioxidant, anti-inflammatory, and enzyme-inhibitory activities. The lab employs advanced techniques such as bioassay-guided fractionation, high-resolution mass spectrometry, and spectroscopic analysis to isolate and characterize novel bioactive molecules.
Figures are computed from collected data and may differ slightly.
Acc2-/- mutant mice, when fed a high-fat/high-carbohydrate (HF/HC) diet, were protected against diet-induced obesity and diabetes. To investigate the role of acetyl-CoA carboxylase 2 (ACC2) in the regulation of energy metabolism in adipose tissues, we studied fatty acid and glucose oxidation in primary cultures of adipocytes isolated from wild-type and Acc2-/- mutant mice fed either normal chow or a HF/HC diet. When fed normal chow, oxidation of [14C]palmitate in adipocytes of Acc2-/- mutant mic
Therapeutic approach of Alzheimer's disease (AD) has been gradually diversified. We examined the therapeutic and preventive potential of andrographolide, which is a lactone diterpenoid from <i>Andrographis paniculata</i>, and focused on the Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated heme oxygenase (HO)-1-inducing effects and the inhibitory activity of amyloid beta (A<i>β</i>)<sub>42</sub>-induced microglial activation related to Nrf2 a
<i>Ecklonia cava</i> is edible seaweed that is found in Asian countries, such as Japan and Korea; and, its major components include fucoidan and phlorotannins. Phlorotannins that are isolated from <i>E. cava</i> are well-known to have an antioxidant effect and strong antiviral activity against porcine epidemic diarrhea virus (PEDV), which has a high mortality rate in piglets. In this study, the bioactive components were determined based on two different approaches: (i) bio-guided isolation using
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