Sungkyunkwan University · 医学
Professor Won-Young Lee's research lab focuses on advanced materials for energy conversion and biomedical applications, with a strong emphasis on understanding and engineering surface and interfacial phenomena in oxides for solid oxide fuel cells and ion conductors. The lab investigates cation segregation, grain boundary effects, and defect chemistry in perovskite and ceria-based materials to enhance oxygen reduction and ion transport properties. In parallel, the lab explores metabolic disease mechanisms, particularly non-alcoholic fatty liver disease (NAFLD) and insulin resistance, using preclinical models and clinical biomarkers. The integration of advanced characterization techniques—such as STEM-EDS, XPS, and Kelvin probe microscopy—with computational modeling and translational biomedical research defines the lab’s interdisciplinary approach.
Figures are computed from collected data and may differ slightly.
Cation segregation on perovskite oxide surfaces affects vastly the oxygen reduction activity and stability of solid oxide fuel cell (SOFC) cathodes. A unified theory that explains the physical origins of this phenomenon is therefore needed for designing cathode materials with optimal surface chemistry. We quantitatively assessed the elastic and electrostatic interactions of the dopant with the surrounding lattice as the key driving forces for segregation on model perovskite compounds, LnMnO3 (ho
Abstract The role of grain boundaries on oxygen surface exchange in an oxide ion conductor is reported. Atomic‐scale characterization of the microstructure and chemical composition near the grain boundaries of gadolinia‐doped ceria (GDC) thin films show the segregation of dopants and oxygen vacancies along the grain boundaries using the energy dispersive spectroscopy in scanning transmission electron microscopy (STEM‐EDS). Kelvin probe microscopy is employed to verify the charge distribution nea
The new non-laboratory-based self-assessment score may be useful for identifying individuals at high-risk of NAFLD. Further studies are warranted to evaluate the utility and feasibility of the scores in various settings.
The effects of exendin-4 on Sirt1 expression as a mechanism of reducing fatty liver have not been previously reported. Therefore, we investigated whether the beneficial effects of exendin-4 treatment on fatty liver are mediated via Sirt1 in high-fat (HF) diet-induced obese C57BL/6J mice and related cell culture models. Exendin-4 treatment decreased body weight, serum free fatty acid (FA), and triglyceride levels in HF-induced obese C57BL/6J mice. Histological analysis showed that exendin-4 rever
The Triglyceride Glucose Index (TyG index) is considered a surrogate marker of insulin resistance. The aim of this study is to investigate whether the TyG index has a predictive role in identifying individuals with a high risk of incident diabetes and to compare it with other indicators of metabolic health. A total 2900 non-diabetic adults who attended five consecutive annual health check-ups at Kangbuk Samsung Hospital was divided into four subgroups using three methods: (1) baseline TyG index;
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