The University of Tokyo · Biochemistry, Genetics and Molecular Biology
우라노 요시테루 교수의 연구실은 생체 내 동적 과정을 실시간으로 관찰할 수 있는 고감도 형광 영상 기술 개발에 초점을 맞추고 있습니다. 특히 암 조기 진단을 위한 선택적이고 신속하게 활성화되는 형광 프로브의 설계와 응용에 주력하며, 종양 세포에서만 발현되는 효소를 타겟으로 한 스마트 형광 프로브를 개발하고 있습니다. 이는 수술 중 또는 내 endoscopy 시 소형 종양을 정밀하게 탐지하는 데 기여합니다.
Figures are computed from collected data and may differ slightly.
Fluorescence imaging is the most powerful technique currently available for continuous observation of dynamic intracellular processes in living cells. Suitable fluorescence probes are naturally of critical importance for fluorescence imaging, but only a very limited range of biomolecules can currently be visualized because of the lack of flexible design strategies for fluorescence probes. At present, design is largely empirical. Here we show that the carboxylic group of traditional fluorescein d
The ability of the unaided human eye to detect small cancer foci or accurate borders between cancer and normal tissue during surgery or endoscopy is limited. Fluorescent probes are useful for enhancing visualization of small tumors but are typically limited by either high background signal or the requirement for administration hours to days before use. We synthesized a rapidly activatable, cancer-selective fluorescence imaging probe, γ-glutamyl hydroxymethyl rhodamine green (gGlu-HMRG), with int
Fluorescence-guided diagnostics is one of the most promising approaches for facile detection of cancer in situ. Here we focus on β-galactosidase, which is overexpressed in primary ovarian cancers, as a molecular target for visualizing peritoneal metastases from ovarian cancers. As existing fluorescence probes are unsuitable, we have designed membrane-permeable HMRef-βGal, in which the optimized intramolecular spirocyclic function affords >1,400-fold fluorescence enhancement on activation. We con
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