Yasuyuki Fujita

The rate of second-case Kawasaki disease occurring among 1788 siblings of children with the disease was derived from data obtained from questionnaires mailed to the members of the Japanese Association of Parents of Children With Kawasaki Disease. Within 1 year after the onset of the first case in a family, the overall second-case rate was 2.1% for siblings, as compared to an overall incidence of approximately 0.19% in the general population of children 0 to 4 years of age in Japan in the epidemi

URL: https://dbcentre3.jmacct.med.or.jp/jmactr/Default.aspx. Unique identifier: JMA-IIA00022)

Attempts to treat congenital protein deficiencies using bone marrow-derived cells have been reported. These efforts have been based on the concepts of stem cell plasticity. However, it is considered more difficult to restore structural proteins than to restore secretory enzymes. This study aims to clarify whether bone marrow transplantation (BMT) treatment can rescue epidermolysis bullosa (EB) caused by defects in keratinocyte structural proteins. BMT treatment of adult collagen XVII (Col17) kno

Epidermolysis bullosa (EB) is a group of genodermatoses characterized by generalized blisters from mutations in the genes encoding the basement membrane zone (BMZ) proteins.1 The infusion of allogeneic cells such as mesenchymal stem/stromal cells (MSCs), which have intact BMZ genes, is a promising treatment.2-6 We here focus on multilineage-differentiating stress-enduring (Muse) cells, which were initially found as a stem cell marker stage-specific embryonic antigen (SSEA)-3-positive subpopulati

CCR10-CTACK/CCL27 interactions between circulating T cells and keratinocytes would seem to play an important role in the pathophysiology of MF from the early disease stages.