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이용석 교수

Yong-Seok Lee

서울대학교 · 의학

연구실 소개

이용석 교수의 연구실은 곤충의 면역 반응과 생체 내 신호 전달 메커니즘을 중심으로, 페놀옥시다제 활성화를 통한 멜라니제이션 반응 조절, TLR2 수용체를 통한 병원성 박테리아 인식, 그리고 고온 환경에서 기능하는 전사 활성화 단백질의 구조 기반 기전 규명 등 생물의 고전적 면역 시스템과 신호 전달 경로의 분자 기전을 연구하고 있습니다. 특히, 곤충의 비특이적 면역 반응에서 핵심적인 역할을 하는 프로페놀옥시다제 활성화 경로와 그 조절 메커니즘을 생화학적·저해상도 구조 생물학적 접근으로 규명하고 있습니다. 이와 더불어, 병원성 박테리아의 리포프로테인을 통해 TLR2를 활성화하는 메커니즘을 정량적 분석을 통해 규명하고 있습니다.

멜라니제이션 반응TLR2 활성화프로페놀옥시다제신호 전달 경로구조 생물학

연구 현황

논문 수
138
총 인용 수
2,290
최근 5년 논문
32
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
32총합
2021
2022
2023
2024
2025
5개년 연도별 피인용 수
259총합
20212022202320242025

주요 논문

15
1
논문|인용수 79·2011
Cilostazol in Acute Ischemic Stroke Treatment (CAIST Trial): A Randomized Double-Blind Non-Inferiority Trial
Yong-Seok Lee, Hee‐Joon Bae, Dong‐Wha Kang, Seung‐Hoon Lee, Kyungho Yu, Jong‐Moo Park, Yong‐Jin Cho, Keun‐Sik Hong, Dong‐Eog Kim, Sun U. Kwon, Kyung Bok Lee, Joung‐Ho Rha
SJR Q2FWCI 4.9Cerebrovascular Diseases

Cilostazol is feasible in acute ischemic stroke, and comparable to aspirin in its efficacy and safety.

Cardiology and Cardiovascular MedicineMedicine
2
논문|인용수 54·2015
Cerebral Microbleeds and Early Recurrent Stroke After Transient Ischemic Attack
Jae‐Sung Lim, Keun‐Sik Hong, Gyeong‐Moon Kim, Oh Young Bang, Hee‐Joon Bae, Hyung‐Min Kwon, Jong‐Moo Park, Seung‐Hoon Lee, Joung‐Ho Rha, Jaseong Koo, Kyung‐Ho Yu, Woo‐Keun Seo
SJR Q1FWCI 5.5JAMA Neurology

Immediate and optimal management seems to modify the risk of recurrent stroke after TIA. Cerebral microbleeds may be novel predictors of stroke recurrence, which needs further validation.

NeurologyMedicine
3
논문|인용수 41·2007
Transcranial Doppler ultrasonographic evaluation of vertebral artery hypoplasia and aplasia
Ju‐Hong Min, Yong-Seok Lee
SJR Q1FWCI 2.0Journal of the Neurological Sciences
SurgeryMedicine
4
논문|인용수 25·2020
Distinct association between cerebral arterial pulsatility and subtypes of cerebral small vessel disease
Ki‐Woong Nam, Hyung‐Min Kwon, Yong-Seok Lee
SJR Q1FWCI 1.3PLoS ONEOA

Ipsilateral PI is closely associated with cSVD in patients with lacunar stroke. Furthermore, this association is different between subtypes of cSVD, which is suggestive of underlying pathophysiological differences.

NeurologyMedicine
5
논문|인용수 24·2017
The correlation between cerebral arterial pulsatility and cognitive dysfunction in Alzheimer's disease patients
Jae‐Sung Lim, Jee‐Young Lee, Hyung‐Min Kwon, Yong-Seok Lee
SJR Q1FWCI 2.2Journal of the Neurological Sciences
Pulmonary and Respiratory MedicineMedicine
6
논문|인용수 22·1999
Neuroprotective effects of lamotrigine enhanced by flunarizine in gerbil global ischemia
Yong-Seok Lee, Byung‐Woo Yoon, Jae‐Kyu Roh
SJR Q2FWCI 1.2Neuroscience Letters
Psychiatry and Mental healthMedicine
7
논문|인용수 22·2021
Effect of obstructive sleep apnea on cerebrovascular compliance and cerebral small vessel disease
Woo‐Jin Lee, Keun‐Hwa Jung, Hyunwoo Nam, Yong-Seok Lee
SJR Q1FWCI 2.0PLoS ONEOA

Reduced cerebrovascular compliance is the major mechanism of cerebral small vessel disease (SVD). Obstructive sleep apnea (OSA) also promotes SVD development, but the underlying mechanism was not elucidated. We investigated the association among OSA, cerebrovascular compliance, and SVD parameters. This study retrospectively included individuals ≥ 50 years of age, underwent overnight polysomnographic (PSG) for the evaluation of OSA, and performed MRI and transcranial Doppler (TCD) within 12 month

PhysiologyMedicine
8
논문|인용수 15·2005
Transcranial Doppler sonography evaluation of anterior cerebral artery hypoplasia or aplasia
Hyung‐Min Kwon, Yong-Seok Lee
SJR Q1FWCI 0.2Journal of the Neurological Sciences
Pulmonary and Respiratory MedicineMedicine
9
논문|인용수 5·2017
대학 영어 전공강의 수강이 대학생들의 학업적 자기효능감과 영어의사소통 자아개념에 미치는 영향
이용석

본 연구에서는 한국교육개발원의 한국교육종단연구 7, 8차년도 데이터를 사용하여 대학교 영어 전공강의가 학생들 의 학업 자기효능감 및 영어 의사소통 자아개념에 미치는 효과를 분석하였다. 우선, 영어전공강의의 선택에 영향을 미치는 요인을 분석하였고, 이를 토대로 경향점수매칭(Propensity Score Matching) 방식을 적용하였다. 추가로, Rosenbaum Bounds와 Mantel-Haenszel Bounds 같은 민감도 분석(Sensitivity Analysis)을 실시하여 비관측 외부요인의 영향력을 확인하였다. 분석 결 과, 영어 전공강의 선택에 있어 전년도 영어강의 수강학점 및 수능 외국어영역 점수, 학업자아개념이 중요한 요인으로 작용 하였으며, 선택편의 조정 이후, 영어 전공강의가 관심 종속변수에 갖는 처치효과의 유의성은 상실되었다. 민감도 분석 결과, 영어 전공강의의 효과는 관찰되지 않은 외부변인의 영향력으로부터 강건하다고 나타났다. 일련의 결과를 바탕으로 대학에서

10
논문|인용수 4·2010
The Linguistic Validation and Reliability of the Korean Version 'Qualiveen Questionnaire'
Yong-Seok Lee, Eunsoo Kim, Seung‐June Oh, Bum-Suk Lee, Dong-A Kim
SJR Q1FWCI 0.4Annals of Rehabilitation MedicineOA

Objective: To translate the English Qualiveen questionnaire which was developed to measure the specific impact of urinary problems on the quality of life of patients with neurogenic bladder into Korean and validate it. Method: First, we made the Korean version Qualiveen questionnaire through translation and cross-cultural adaptation followed by the international guideline. This process consisted of 6 steps including translation, reconciliation, back translation into English and debriefing. And t

RheumatologyMedicine
11
논문|인용수 3·2019
A comparison of transcranial Doppler and magnetic resonance imaging for long term changes in middle cerebral artery stenosis
Chan-Hyuk Lee, Dallah Yoo, Hyung‐Min Kwon, Yong-Seok Lee
SJR Q2FWCI 0.3Clinical Neurology and Neurosurgery
Pulmonary and Respiratory MedicineMedicine
12
논문|인용수 3·2003
Nonpulsatile Cerebral Perfusion in Takayasu’s Arteritis
Yong-Seok Lee, Byung‐Woo Yoon, Jae‐Kyu Roh
SJR Q1Journal of Neuroimaging
Pulmonary and Respiratory MedicineMedicine
13
논문|인용수 3·2018
Two­-Stage Reimplantation in Infected Total Knee Arthroplasty
이용석, Antonia F. Chen

Two­-stage reimplantation is considered the gold standard for the management of periprosthetic joint infection. The first stage involves the removal of the prosthesis, followed by extensive debridement of all nonviable tissues, synovectomy, irrigation, and reaming of the medullary canals. Once the joint has been prepared, antibiotic­-impregnated cement beads and/or spacer are inserted. Antibiotic-­impregnated spacers are now more commonly used, and an increasing number of orthopaedic surgeons ar

14
논문|인용수 2·2022
Cardiovascular risk scores in asymptomatic carotid stenosis: A validation study with ultrasonographic parameters
Min Kyoung Kang, Ki‐Woong Nam, Jung Hwan Shin, Hyung‐Min Kwon, Yong-Seok Lee
SJR Q1FWCI 0.3PLoS ONEOA

We evaluated the feasibility of the Framingham stroke risk score (FSRS) and atherosclerotic cardiovascular disease (ASCVD) risk scores for asymptomatic carotid stenosis (ACS). In addition, we developed novel risk prediction models for ischemic stroke and composite outcomes by combining ultrasonographic parameters and conventional cardiovascular risk scores. We retrospectively enrolled 612 patients with ACS greater than 50% over 7 years and evaluated them using transcranial Doppler and carotid du

Pulmonary and Respiratory MedicineMedicine
15
논문|인용수 2·2009
Fabrication of a Bottom Electrode for a Nano-scale Beam Resonator Using Backside Exposure with a Self-aligned Metal Mask
이용석, 김정무, 김종만, 장윤호, 김용권, Yong-Seung Bang

In this paper, we describe a self-aligned fabrication method for a nano-patterned bottom electrode using flood exposure from the backside. Misalignments between layers could cause the final devices to fail after the fabrication of the nano-scale bottom electrodes. A self-alignment was exploited to embed the bottom electrode inside the glass substrate. Aluminum patterns act as a dry etching mask to fabricate glass trenches as well as a self-aligned photomask during the flood exposure from the bac

대표 연구 분야

Pulmonary and Respiratory MedicineEpidemiologyCardiology and Cardiovascular MedicineNeurologyRehabilitationRadiology, Nuclear Medicine and Imaging

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