东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Noritaka Chida's research laboratory specializes in the development of innovative synthetic methodologies for complex natural products, with a strong emphasis on chemoselective transformations and stereoselective synthesis. The lab focuses on designing efficient, protecting-group-minimized routes to bioactive molecules, particularly alkaloids and antibiotics, using unique reactivity patterns such as N-methoxyamide chemistry and metal-catalyzed rearrangements. Key strategies include the Overman rearrangement, Ferrier-type rearrangements, and iridium-catalyzed reductive additions, enabling concise and enantioselective total syntheses. The work consistently emphasizes functional group tolerance and atom economy, contributing significantly to synthetic organic chemistry and drug discovery.
Professor Koichi Murata's research lab focuses on the molecular mechanisms underlying inflammatory and musculoskeletal diseases, particularly rheumatoid arthritis (RA) and osteoarthritis (OA). The lab investigates microRNAs (miRNAs) as key regulators of disease progression and diagnostic biomarkers, exploring their roles in synovial fluid and plasma to differentiate disease phenotypes and assess disease activity. Additionally, the lab examines the impact of therapeutic agents like methotrexate on surgical outcomes and investigates miRNA involvement in tissue repair processes such as fracture healing. The research integrates clinical observations with molecular biology to identify novel therapeutic targets and biomarkers for rheumatic diseases.
Professor Takashi Nomura's research lab focuses on parasitology and immunology, with a central emphasis on understanding the molecular mechanisms of drug resistance in malaria parasites, particularly chloroquine resistance in *Plasmodium vivax* and related species. The lab investigates the role of *pfcrt* homologues in parasite drug resistance and explores the genetic and evolutionary basis of antimalarial resistance. Additionally, the lab examines immune dysregulation in inflammatory skin diseases such as atopic dermatitis, with a focus on T-cell subsets (Th1, Th2, Th17, and Treg cells) and their cytokine networks in disease pathogenesis and treatment response. The integration of parasitology, immunogenetics, and translational medicine defines the lab’s interdisciplinary approach to infectious and immune-mediated diseases.
Professor Arihiro Kanazawa's research lab specializes in the development of advanced cationic polymerization methodologies, with a strong focus on living cationic polymerization of vinyl ethers and epoxides. The lab pioneers novel initiating systems—ranging from metal halides and metal oxides to Lewis acid-free catalysts—enabling precise control over molecular weight and polydispersity. Key research directions include the design of efficient, reusable heterogeneous catalysts and the synthesis of well-defined block copolymers through controlled crossover reactions. The lab emphasizes mechanistic understanding and practical applicability, particularly in sustainable and scalable polymer synthesis.
Professor Tomohiro Yamazaki's research lab focuses on the molecular mechanisms underlying RNA-mediated cellular organization, particularly the role of long non-coding RNAs (lncRNAs) in forming biomolecular condensates through phase separation. The lab investigates how lncRNAs such as NEAT1_2 act as scaffolds for nuclear bodies like paraspeckles, and how RNA-binding proteins like FUS and helicases (e.g., UAP56, URH49) regulate mRNA export and condensate dynamics. They also explore the pathophysiological implications of these mechanisms in neurodegenerative diseases such as ALS and SMA, as well as in infectious diseases involving host-pathogen interactions in the genital tract. The lab integrates molecular cell biology, RNA biology, and biophysics to understand the functional architecture of subcellular compartments.
Professor Hironori Tohmyoh's research lab specializes in nanoscale materials characterization and interfacial phenomena, with a focus on the mechanical, thermal, and acoustic behaviors of nanostructures. Key research directions include the development of in-situ electron microscopy techniques for nanowire welding and cutting via Joule heating, molecular dynamics simulations of carbon nanotube–metal nanowire heterostructures, and advanced ultrasonic spectroscopy for thin-film property evaluation. The lab also investigates dry-contact ultrasonic imaging and acoustic impedance measurement in low-density polymer films, emphasizing high-precision, non-destructive characterization methods at the micro- and nanoscale.
Professor Ryoukichi Ikeda's research lab specializes in otolaryngology, with a primary focus on the diagnosis, pathophysiology, and treatment of Eustachian tube (ET) disorders, particularly Eustachian Tube Dysfunction (ETD) and Paradoxical Eustachian Tube (PET) function. The lab investigates innovative interventions such as the Kobayashi Plug and balloon dilation tuboplasty (BET), emphasizing clinical outcomes, device efficacy, and the development of diagnostic criteria using imaging and functional testing. Their work also explores the surgical management of related conditions like cholesteatoma and labyrinthine fistulas, with a strong emphasis on preserving hearing and improving patient-reported outcomes.
Professor Kartik Sau's research lab specializes in computational materials science with a focus on designing advanced solid-state electrolytes for next-generation all-solid-state batteries and solid-state cooling technologies. The lab employs advanced molecular dynamics simulations and first-principles calculations to unravel ion transport mechanisms, particularly in superionic conductors and complex hydrides, emphasizing the role of anion dynamics, ion–ion correlations, and structural disorder in enhancing ionic conductivity. A key research direction involves understanding and engineering phase transitions and dynamic disorder to achieve high-performance, safe, and scalable energy materials. The lab also explores caloric materials for environmentally friendly solid-state cooling, aiming to overcome limitations in efficiency and hysteresis.
Professor Kohei Shimokawa's research lab focuses on advancing next-generation rechargeable battery technologies, with a primary emphasis on magnesium-ion batteries. The lab explores innovative cathode materials that resist detrimental phase transitions—such as spinel-to-rocksalt transformation—through strategic element doping and structural design. It also investigates novel electrolyte systems, including highly concentrated Mg(TFSA)₂/triglyme solutions and water-in-salt electrolytes, to overcome passivation issues and enable reversible Mg plating/stripping. Additionally, the lab pioneers photo-rechargeable battery concepts using light-driven cathode reactions, demonstrating sustainable energy storage strategies beyond conventional charging.
Professor Tanmoy Roy Tusher's research lab specializes in environmental biotechnology and sustainable remediation, focusing on the development of microbial and biotechnological solutions for industrial and urban water pollution. The lab investigates the biodegradation of emerging contaminants such as 1,4-dioxane and pharmaceuticals in wastewater, with an emphasis on microbial consortia and engineered systems like microbial fuel cells. It also explores environmental risks associated with urban agriculture, including heavy metal and PAH contamination in rooftop-grown vegetables, and evaluates the role of organic amendments in improving soil health and reducing pollutant mobility. The lab integrates environmental microbiology, analytical chemistry, and ecological risk assessment to address pressing urban and industrial environmental challenges.
Professor Mehrdad Elyasi's research lab specializes in nonlinear spin dynamics and topological phenomena in magnetic nanostructures, with a focus on exploiting intrinsic nonlinearities and quantum effects for emerging quantum and unconventional computing technologies. The lab investigates magnon-based systems such as spintronic oscillators, magnonic solitons, and nonlinear spin Seebeck effects, particularly in topologically nontrivial lattices and low-dimensional systems. Key themes include quantum information resources like entanglement and squeezing, synchronization of spintronic devices via spin current feedback, and the role of nonlinear magnon interactions in enabling probabilistic computing with p-bits. The work bridges fundamental many-body spin physics with applications in quantum simulation, low-power computing, and spin-based information processing.
Professor Tomoka Hasegawa's research lab specializes in skeletal biology, focusing on the cellular and molecular mechanisms regulating bone mineralization, remodeling, and disease. The lab investigates key regulators such as matrix vesicles, osteocyte-derived factors like sclerostin and DMP1, and the roles of enzymes like TNAP and ENPP1 in controlling calcium and phosphate homeostasis. Using animal models of metabolic bone disorders—including osteoporosis, vitamin D deficiency, and chronic kidney disease—her team explores therapeutic interventions such as parathyroid hormone analogs and calcimimetics to modulate bone formation and resorption. The lab integrates histomorphometry, immunohistochemistry, and molecular analyses to understand pathological bone changes at the cellular and subcellular levels.
Professor Osamu Fujita's research lab specializes in quantum materials and advanced semiconductor devices, focusing on spin-based phenomena in low-dimensional systems and novel memory technologies for next-generation computing. The lab investigates quantum spin systems such as spin-Peierls compounds using neutron scattering to probe magnetic excitation gaps and field-induced quantum transitions. In parallel, the lab develops innovative floating-gate MOSFET devices with dual floating gates for high-resolution analog memory, enabling applications in neuromorphic computing and low-power LSIs. The integration of fundamental quantum physics with practical nanoelectronic device design defines the lab's interdisciplinary approach.
Professor Hisanori Senboku's research lab specializes in electrochemical carbon dioxide fixation, focusing on the development of sustainable methods for converting CO₂ into valuable carboxylic acids and related compounds. The lab pioneers electrochemical carboxylation reactions using various organic substrates—such as alkenes, vinyl halides, α-aminosulfones, and benzal diacetates—under mild conditions with atmospheric CO₂. Key innovations include the generation of aryl radicals for cyclization and carboxylation, reductive C–S bond cleavage, and selective functionalization of fluorinated and non-fluorinated arenes. The work has strong applications in pharmaceutical synthesis, particularly for non-steroidal anti-inflammatory drugs (NSAIDs) and other bioactive molecules.
Professor Naoya Kumagai's research lab specializes in the development of innovative catalytic systems for stereoselective organic synthesis, with a strong focus on asymmetric catalysis using earth-abundant metals such as zinc and copper. The lab pioneers cooperative catalysis strategies that combine multiple catalytic components—such as transition metals, organic bases, and additives—to achieve high enantio- and diastereoselectivity under mild reaction conditions. Key research directions include the design of chiral ligands and bimetallic complexes for aldol and Mannich-type reactions, as well as the enantioselective construction of challenging stereogenic centers, including those bearing trifluoromethyl groups. The lab also explores atom-economical transformations and mechanistic understanding to guide the rational design of new catalytic systems.
Professor Shigeaki Suzuki's research lab specializes in neuroimmunology and inflammatory myopathies, focusing on the pathogenesis, serological markers, and cytokine involvement in autoimmune neurological disorders. The lab investigates autoantibodies such as anti-SRP and anti-HMGCR in immune-mediated necrotizing myopathy and antisynthetase syndrome, exploring their clinical and histological correlations. A key focus is on the role of pro-inflammatory and neurotrophic cytokines—particularly interleukin-6 (IL-6)—in central nervous system disorders, including stroke, where IL-6's dual role in neuroinflammation and repair is being dissected at the cellular and spatial level. The lab employs advanced immunohistochemical and molecular techniques to map cytokine expression and cellular sources in experimental models of cerebral ischemia.
Professor Yusuke Takezawa's research lab specializes in the design and synthesis of artificial DNA base pairs that incorporate metal ions, enabling the creation of stimuli-responsive and functional DNA-based materials. The lab focuses on metal-mediated base pairing systems—particularly those involving transition and lanthanide metals—to achieve precise control over DNA structure, stability, and function. Key research directions include the development of novel ligand-based nucleotides, enzymatic synthesis of artificial DNA, and the construction of dynamic DNA nanostructures such as three-way junctions and supermolecules with tailored properties. The lab also explores applications in DNA-templated metal assembly and responsive materials for biotechnology and nanotechnology.
Professor Hongyuan Jia's research lab specializes in atmospheric boundary-layer modeling and micrometeorology, with a focus on footprint modeling for complex urban environments. The lab develops advanced numerical methods—such as adjoint-based backward-Eulerian models—to accurately estimate concentration and flux footprints under varying atmospheric stability and urban surface heterogeneity. Their work integrates wind tunnel experiments with computational simulations to validate models and improve the understanding of pollutant dispersion and surface-atmosphere exchange in cities. The lab also emphasizes the impact of sensor height and wind direction on footprint heterogeneity in urban canopies.
Professor Meng An's research lab specializes in the design and development of advanced functional materials for sustainable energy and environmental applications. The lab focuses on biomimetic and nanostructured materials, particularly for solar-driven interfacial evaporation, water purification, and humidity-responsive systems. Key research directions include the rational engineering of hydrogels, cellulose-based composites, and graphene oxide hybrids to achieve high-performance, scalable solutions for freshwater production and energy conversion.
Professor Avadhesh Kumar Sharma's research lab specializes in advanced thermal and fluid dynamics, with a strong focus on aerosol control and heat transfer in extreme environments. The lab investigates innovative methods for efficient aerosol scavenging—particularly submicron radioactive aerosols—during nuclear decommissioning, especially at the Fukushima Daiichi Nuclear Power Plant. Key research directions include optimizing water spray systems for aerosol agglomeration, enhancing impingement jet cooling for hot surface quenching, and developing safe, remote decontamination and debris retrieval techniques. The work bridges nuclear safety, environmental protection, and industrial process optimization.
