东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Masaki Kawano's research lab specializes in the dynamic structural characterization of transient reactive intermediates—particularly carbenes and radical pairs—using in situ X-ray crystallography under controlled conditions such as low temperature and light irradiation. The lab focuses on understanding the structural and electronic changes during solid-state photoreactions, with an emphasis on the formation and reactivity of short-lived species like triplet carbene and radical pairs in crystalline environments. Their work uniquely combines single-crystal X-ray diffraction, spectroscopy, and theoretical calculations to probe reaction mechanisms at the atomic level in real time. The lab also explores functional porous coordination networks with stimuli-responsive behavior, including reversible guest adsorption and framework dynamics.
Professor Rui Kato's research lab specializes in the analysis and control of networked and cyber-physical systems under adversarial conditions, with a focus on security and stability. The lab investigates the resilience of nonlinear control systems against Denial-of-Service (DoS) attacks, particularly through quantized feedback and linearization-based approaches under limited data rates. A key research direction involves developing robust control strategies—such as resilient dynamic quantizers and switched system models—that ensure asymptotic and local stability despite packet losses and attack-induced disruptions. The lab also explores cluster synchronization in complex oscillator networks, applying averaging methods and Lyapunov techniques to understand synchronization dynamics in heterogeneous systems.
Professor Yasuyuki Ishida's research lab focuses on urban microclimate dynamics, with a strong emphasis on urban heat island mitigation, wind environment around high-rise buildings, and the integration of urban sensing technologies. The lab investigates the impacts of urban morphology—such as building height, surface albedo, and impervious surfaces—on land surface temperature and local wind patterns in megacities like Tokyo and Shanghai. It also explores innovative sensing methods using wearable devices, RFID, and remote sensing to monitor urban environmental conditions in complex urban environments. The lab combines field observations, wind tunnel experiments, and advanced data analysis to support sustainable urban planning and climate resilience.
Professor Michiaki Unno's research lab focuses on pancreatic cancer therapeutics and regenerative biology, with a central emphasis on neoadjuvant chemotherapy strategies using gemcitabine and S-1 to improve outcomes in resectable and borderline resectable pancreatic ductal adenocarcinoma (PDAC). The lab investigates the role of the Reg gene family in pancreatic islet regeneration and beta-cell proliferation, exploring its potential for treating diabetes and enhancing tissue repair. Through translational studies and preclinical models, including Reg knockout mice, the lab aims to uncover molecular mechanisms underlying pancreatic regeneration and cancer progression. Their work bridges clinical oncology, molecular biology, and regenerative medicine to develop novel therapeutic approaches for pancreatic diseases.
Professor Makoto Ohta's research lab focuses on tumor microenvironment interactions, particularly the role of macrophages in cancer angiogenesis across gastrointestinal malignancies such as esophageal and gastric carcinomas. The lab investigates molecular mechanisms involving chemokines like MCP-1/CCR2 and angiogenic factors such as VEGF, using clinical specimens and cell line models to elucidate tumor-stroma crosstalk. Additionally, the lab explores biomaterials for medical simulation, developing tissue-mimicking phantoms with optimal mechanical and imaging compatibility for vascular and hemodynamic studies. These interdisciplinary efforts bridge cancer biology, translational medicine, and biomedical engineering.
Professor Yu Kumagai's research lab specializes in computational materials science, focusing on the electronic structure, defect physics, and thermodynamic stability of advanced functional materials. The lab employs first-principles density functional theory (DFT) calculations to investigate point defects, vacancy formation energies, and doping behavior in semiconductors and oxides, with applications in photovoltaics, thermoelectrics, and optoelectronics. A key strength lies in developing accurate defect energy correction methods and high-throughput computational workflows, enabling predictive insights into material properties and guiding experimental design. The lab also pioneers machine learning approaches to accelerate defect property prediction across large material spaces.
Professor Chrystelle Bernard's research lab specializes in the thermomechanical behavior and processing of advanced polymeric materials, with a focus on high-performance and semi-crystalline polymers. The lab investigates complex deformation mechanisms under large strains, strain rate effects, and microstructure evolution during forming and coating processes such as thermoforming and cold spraying. Key research directions include the development of accurate 3D constitutive models, experimental validation under multi-axial loading, and the optimization of processing parameters to enhance interfacial adhesion and material performance.
Professor Tatsuki Tsujimori's research lab specializes in high-pressure and low-temperature metamorphism, with a focus on subduction zone processes, eclogite and blueschist formation, and the petrology of HP/UHP rocks. The lab investigates the P–T conditions, mineralogical transformations, and tectonic evolution of metamorphic terranes, particularly in orogenic belts such as the Circum-Pacific, Alpine-Himalayan, and Caledonian regions. Key research directions include the petrology of jadeitite and lawsonite-bearing rocks, zircon geochronology in subduction-related settings, and the role of fluids and trace elements in metamorphic reactions. The lab integrates fieldwork, microtextural analysis, and high-precision geochronology (e.g., SHRIMP-RG U/Pb dating) to reconstruct deep Earth processes in convergent margins.
Professor Yuta Takahashi's research lab specializes in the intersection of neuroscience, psychiatry, and molecular biology, focusing on the pathophysiological mechanisms underlying psychiatric disorders and amyloid-related diseases. The lab investigates microglial and monocytic immune activation in psychiatric conditions such as schizophrenia and depression, exploring neuro-immune interactions and their implications for disease progression. Additionally, the lab develops advanced computational and systems biology approaches—such as machine learning and polygenic prediction models—to identify metabolic and genetic biomarkers for psychiatric phenotypes. A significant component of the research also involves the structural engineering of amyloid fibrils for both pathological insight and potential biomaterial applications.
Professor Akira Koarai's research lab focuses on the immunological and inflammatory mechanisms underlying chronic airway diseases, particularly chronic obstructive pulmonary disease (COPD) and asthma. The lab investigates the role of non-neuronal cholinergic systems, oxidative stress, and innate immune receptors such as TLR3 in driving airway inflammation and remodeling. Key research directions include the contribution of endogenous mediators like acetylcholine, 25-hydroxycholesterol, and histamine to neutrophilic and eosinophilic inflammation, as well as the therapeutic potential of muscarinic receptor antagonists beyond bronchodilation. The lab integrates molecular immunology, cell signaling, and translational approaches using primary human cells and disease models to uncover novel targets for airway disease treatment.
Professor Harry Aginta's research lab specializes in regional economic dynamics in Indonesia, with a focus on income and price convergence, monetary policy transmission, and financial inclusion across provinces and districts. The lab employs advanced econometric methods such as dynamic factor models, SVAR, and club convergence analysis to examine structural disparities and policy impacts in decentralized economies. Key research directions include regional inequality, the role of economic structure in monetary transmission, and the distributional effects of financial inclusion.
Professor Seitaro Terakura's research lab focuses on advancing adoptive T cell therapy for hematological malignancies, with a central emphasis on improving the safety and efficacy of chimeric antigen receptor (CAR) T cells. The lab investigates critical aspects such as antigen density thresholds for CAR-T cell activation, inducible CAR systems to control toxicity, and the role of minor histocompatibility antigens—particularly UGT2B17—in graft-versus-host disease and immune responses after allogeneic hematopoietic stem cell transplantation. By combining molecular engineering of CARs with clinical-grade T cell manufacturing and immunogenetic analysis, the lab aims to develop precision T cell therapies that minimize off-tumor effects and enhance long-term persistence.
Professor Kohei Ito's research lab specializes in advanced energy conversion and spintronic devices, focusing on optimizing energy efficiency in electrochemical systems and next-generation magnetic memory technologies. The lab investigates fundamental mechanisms in polymer electrolyte membrane water electrolysis, particularly hydrogen gas crossover and bubble dynamics, to enhance current efficiency through tailored surface wettability. Concurrently, the lab explores spintronic phenomena such as spin transfer torque switching with precessional motion, aiming to drastically reduce energy consumption in magnetic memory devices. These interdisciplinary efforts bridge materials science, nanomagnetism, and electrochemical engineering to develop sustainable and high-performance energy and information technologies.
Professor Naoki Hashimoto's research lab focuses on the intersection of organic chemistry and materials science, particularly in the development of fluorescent phosphine-based compounds with tunable photophysical properties. The lab also investigates chemical stability and degradation pathways in food systems, such as the formation of off-flavors in stored beer due to aldehyde generation via melanoidin-catalyzed oxidation. Additionally, the lab contributes to psychiatric pharmacology through clinical studies on antipsychotic treatment patterns and cognitive outcomes in schizophrenia, emphasizing medication optimization and long-term treatment effectiveness. These diverse research directions reflect a strong commitment to both fundamental chemical innovation and applied health sciences.
Professor Mai Takashima's research lab specializes in the design, characterization, and application of advanced photocatalytic materials, with a strong focus on titania-based systems and their heterostructures. The lab investigates fundamental aspects of photocatalytic activity, including charge transfer dynamics, facet-dependent reactivity, and light-matter interactions, using advanced spectroscopic techniques such as reversed double-beam photoacoustic spectroscopy. Key research directions include the development of structured photocatalysts—such as inverse-opal photonic crystals and core-shell nanostructures—to enhance light absorption and reaction efficiency through precise engineering of electronic and optical properties. The lab also explores multimodal electron transfer processes and interfacial charge transfer at oxide heterojunctions, aiming to clarify structure-activity relationships for sustainable energy and environmental applications.
Professor Hidetaka Ito's research lab focuses on the molecular mechanisms underlying transposable element (TE) activation in plants, particularly in response to environmental stresses such as heat and oxidative stress. The lab investigates how epigenetic regulation—especially DNA methylation and small RNA pathways—controls TE activity and influences host gene expression, with a central emphasis on the retrotransposon ONSEN in Arabidopsis. Their work reveals how stress-induced TE mobilization can lead to adaptive genetic variation, linking genome plasticity to environmental adaptation and evolution. The lab also explores the roles of specific DNA methyltransferases, such as CMT3 and CMT2, in regulating TE silencing and activation through distinct methylation contexts (CHG and CHH).
Professor Sei-ichiro Kamata's research lab specializes in image processing, data compression, and spatial indexing techniques with a focus on the application of space-filling curves—particularly the Hilbert curve—in digital image and signal processing. The lab explores efficient algorithms for image scanning, lossy and lossless compression, and hierarchical image representation, emphasizing computational speed and hardware-friendly implementations. Key research directions include bit-plane decomposition, neighborhood-preserving mappings, and optimization of curve-based data organization for remote sensing and image database applications.
Professor Takeo Kosaka's research lab focuses on understanding the molecular mechanisms underlying prostate cancer progression, particularly castration-resistant prostate cancer (CRPC), with an emphasis on therapy resistance, tumor angiogenesis, and epithelial-mesenchymal transition (EMT). The lab investigates key signaling pathways such as Akt activation and transcriptional regulators like Snail and OCT4 to identify novel therapeutic targets and biomarkers. Utilizing advanced models including drug-resistant cell lines and gene expression profiling, the lab aims to develop effective treatments for advanced, treatment-refractory prostate cancer.
Professor Toshinori Sato's research lab focuses on molecular and biochemical mechanisms underlying plant hormone signaling, particularly the regulation of ethylene biosynthesis through ACC synthase. The lab also investigates protein-lipid interactions, especially the role of gangliosides in neurodegenerative diseases, and develops advanced analytical techniques for structural characterization of biomolecules. Their work spans plant molecular biology, neurochemistry, and mass spectrometry-based structural analysis.
Professor Deokho Lee's research lab specializes in retinal ischemia and ocular neovascularization, focusing on the molecular and cellular mechanisms underlying retinal vascular diseases. The lab develops and utilizes innovative animal models, such as unilateral common carotid artery occlusion (UCCAO), to study localized retinal ischemia without systemic brain involvement, enabling detailed investigation of ischemic retinopathies. Key research directions include the role of hypoxia-inducible factor (HIF) and vascular endothelial growth factor (VEGF) in pathological angiogenesis, and the therapeutic potential of novel agents like pemafibrate, a PPARα modulator, in protecting against retinal degeneration. The lab also explores the long-term consequences of anti-VEGF therapy, such as chorioretinal atrophy, aiming to balance effective treatment with preservation of retinal homeostasis.
