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An Hye-jin

Kyung Hee University · 医学

研究室紹介

Professor An Hye-jin's research lab specializes in parasitology and infectious disease immunology, with a primary focus on Toxoplasma gondii and Neospora caninum, two apicomplexan parasites affecting both humans and animals. The lab investigates host-parasite interactions at the molecular level, particularly the role of parasitic dense granule proteins (GRAs) in pathogenesis and immune evasion. Key research directions include identifying parasite protein interactions with host cellular machinery, developing serological diagnostic tools using recombinant antigens, and exploring the epidemiological and clinical implications of parasitic infections in human and veterinary populations. The lab also examines the broader impact of chronic infections on mental and systemic health, as seen in studies linking parasitic and inflammatory skin conditions with depression.

Toxoplasma gondiihost-parasite interactionserodiagnosisGRA proteinszoonotic parasitic diseases

Research Overview

Papers
208
Total Citations
1,627
Papers (5y)
91
Primary Field
医学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
91total
2022
2023
2024
2025
2026
Citations per year (5y)
238total
20222023202420252026

Selected Papers

15
1
Review|54 citations·2021
Sugar-sweetened beverage consumption and bone health: a systematic review and meta-analysis
Hyejin Ahn, Yoo Kyoung Park
SJR Q1Nutrition JournalOA

BACKGROUND: Current evidence demonstrate that sugar-sweetened beverages (SSBs) and bone health are related; however, there has been only a few reviews on the link between SSBs and bone health. A systematic review and meta-analysis was performed to investigate the association between SSBs consumption and bone health in chidren and adults. METHODS: Relevant studies of SSBs and bone health published up to 15 March 2021 were searched using PubMed, the Web of Science, Cochrane Library, and a referenc

Endocrinology, Diabetes and MetabolismMedicine
2
Article|50 citations·2019
<p>Cross-sectional study of psychiatric comorbidities in patients with atopic dermatitis and nonatopic eczema, urticaria, and psoriasis</p>
Hye‐Jin Ahn, Min Kyung Shin, Jong‐Kil Seo, Su Jin Jeong, Ah Rang Cho, Sun Hee Choi, Bark‐Lynn Lew
SJR Q2Neuropsychiatric Disease and TreatmentOA

<b>Background:</b> Recent data suggest depression has been linked to chronic skin diseases, including atopic dermatitis (AD), urticaria, and psoriasis. This study compared mental illnesses in patients with AD with those of patients with nonatopic eczema, urticaria, and psoriasis in Korea. <b>Methods:</b> A cross-sectional study design was used, analyzing data from the 2015 Korean National Health Insurance Research Database, a survey of 42,641 AD and 139,486 non-AD (nonatopic eczema, urticaria, a

DermatologyMedicine
3
Article|50 citations·2003
Molecular cloning of the 82-kDa heat shock protein (HSP90) of Toxoplasma gondii associated with the entry into and growth in host cells
Hye‐Jin Ahn, Sera Kim, Ho‐Woo Nam
SJR Q2Biochemical and Biophysical Research Communications
Molecular BiologyBiochemistry, Genetics and Molecular Biology
4
Article|37 citations·2006
Interactions between secreted GRA proteins and host cell proteins across the parasitophorous vacuolar membrane in the parasitism of Toxoplasma gondii
Hye‐Jin Ahn, Sehra Kim, Hee-Eun Kim, Ho‐Woo Nam
Korean Journal of ParasitologyOA

Interactions between GRA proteins of dense granules in Toxoplasma gondii and host cell proteins were analyzed by yeast two-hybrid technique. The cMyc-GRA fusion proteins expressed from pGBKT7 plasmid in Y187 yeast were bound to host cell proteins from pGADT7-Rec-HeLa cDNA library transformed to AH109 yeast by mating method. By the selection procedures, a total of 939 colonies of the SD/-AHLT culture, 348 colonies of the X-alpha-gal positive and PCR, 157 colonies of the X-beta-gal assay were chos

ParasitologyImmunology and Microbiology
5
Article|30 citations·2005
Host cell binding of GRA10, a novel, constitutively secreted dense granular protein from Toxoplasma gondii
Hye‐Jin Ahn, Sehra Kim, Ho‐Woo Nam
SJR Q2Biochemical and Biophysical Research Communications
ParasitologyImmunology and Microbiology
6
Article|23 citations·2009
STAT6 activation by Toxoplasma gondii infection induces the expression of Th2 C-C chemokine ligands and B clade serine protease inhibitors in macrophage
Hye‐Jin Ahn, Ji Yeon Kim, Kyung-Ju Ryu, Ho‐Woo Nam
SJR Q1Parasitology Research
ParasitologyImmunology and Microbiology
7
Article|23 citations·2001
Protease Activity and Host Cell Binding of the 42-kDa Rhoptry Protein from Toxoplasma gondii after Secretion
Hye‐Jin Ahn, Kyoung-Ju Song, Eui-Sun Son, Jong-Chul Shin, Ho‐Woo Nam
SJR Q2Biochemical and Biophysical Research Communications
ParasitologyImmunology and Microbiology
8
Article|21 citations·2003
ELISA detection of IgG antibody against a recombinant major surface antigen (Nc-p43) fragment of Neospora caninum in bovine sera
Hye‐Jin Ahn, Sera Kim, Dae-Yong Kim, Ho‐Woo Nam
Korean Journal of ParasitologyOA

An ELISA was established to measure bovine IgG directed against the recombinant antigenic determinant of Nc-p43, a major surface antigen of Neospora caninum. In a previous study, two thirds of the C-terminal of the molecule was expressed as a 6 x His tagged protein (Ncp43P) for ELISA using 2/3 of the N-terminal of SAG1 from Toxoplasma gondii as a control (TgSAG1A). Among 852 cattle sera collected from stock farms scattered nation-wide, 103 sera (12.1%) were found to react with Ncp43P positively,

ParasitologyImmunology and Microbiology
9
Article|19 citations·2014
Calorie restriction aggravated cortical and trabecular bone architecture in ovariectomy-induced estrogen-deficient rats
Hye‐Jin Ahn, Dong-Hyun Seo, Han Sung Kim, Ryowon Choue
SJR Q1Nutrition Research
GeneticsBiochemistry, Genetics and Molecular Biology
10
Article|18 citations·2012
Seroprevalence of Toxoplasmosis in the Residents of Cheorwon-gun, Gangwon-do, Korea
Hyejin Ahn, Pyo Yun Cho, Seong Kyu Ahn, Tong‐Soo Kim, Chom‐Kyu Chong, Sung‐Jong Hong, Seok Ho, Ho‐Woo Nam
Korean Journal of ParasitologyOA

The seroepidemiological status of toxoplasmosis was surveyed among the residents of Cheorwon-gun, Gangwon-do by means of ELISA using a crude extract antigen of Toxoplasma gondii. The sera of 1,661 adult residents (866 males and 795 females) were collected and checked for IgG antibody titers, which showed 17.0% positive rate (282 sera). The positive rate was significantly different between the sex; 20.6% for males and 13.1% for females (P<0.05). The positive rates were higher in fifties of males

ParasitologyImmunology and Microbiology
11
Article|18 citations·2014
Successful Renal Transplantation in MYH9-Related Disorder With Severe Macrothrombocytopenia: First Report in Korea
Sun Young Min, Hye‐Jin Ahn, W.S. Park, J.W. Kim
SJR Q3Transplantation Proceedings
HematologyMedicine
12
Article|15 citations·2016
Soy isoflavone supplementation improves longitudinal bone growth and bone quality in growing female rats
Hye‐Jin Ahn, Yoo Kyoung Park
SJR Q2Nutrition
Pathology and Forensic MedicineMedicine
13
Article|12 citations·2007
Nucleolar translocalization of GRA10 of Toxoplasma gondii transfectionally expressed in HeLa cells
Hye‐Jin Ahn, Sehra Kim, Ho‐Woo Nam
Korean Journal of ParasitologyOA

Toxoplasma gondii GRA10 expressed as a GFP-GRA10 fusion protein in HeLa cells moved to the nucleoli within the nucleus rapidly and entirely. GRA10 was concentrated specifically in the dense fibrillar component of the nucleolus morphologically by the overlap of GFP-GRA10 transfection image with IFA images by monoclonal antibodies against GRA10 (Tg378), B23 (nucleophosmin) and C23 (nucleolin). The nucleolar translocalization of GRA10 was caused by a putative nucleolar localizing sequence (NoLS) of

ParasitologyImmunology and Microbiology
14
Article|11 citations·2021
Functional Neural Correlates of Semantic Fluency Task Performance in Mild Cognitive Impairment and Alzheimer’s Disease: An FDG-PET Study
Hye‐Jin Ahn, Dahyun Yi, Kyungjin Chu, Haejung Joung, Younghwa Lee, Gijung Jung, Kiyoung Sung, Dong‐Kyun Han, Jun Ho Lee, Min Soo Byun, Dong Young Lee
SJR Q1Journal of Alzheimer s DiseaseOA

BACKGROUND: Total score (TS) of semantic verbal fluency test (SVFT) is generally used to interpret results, but it is ambiguous as to specific neural functions it reflects. Different SVFT strategy scores reflecting qualitative aspects are proposed to identify specific cognitive functions to overcome limitations of using the TS. OBJECTIVE: Functional neural correlates of the TS as well as the other strategy scores in subjects with mild cognitive impairment (MCI) and Alzheimer's disease (AD) demen

Psychiatry and Mental healthMedicine
15
Article|11 citations·2009
IL-4 Independent Nuclear Translocalization of STAT6 in HeLa Cells by Entry of Toxoplasma gondii
Hye‐Jin Ahn, Ji Yeon Kim, Ho‐Woo Nam
Korean Journal of ParasitologyOA

Toxoplasma gondii provokes rapid and sustained nuclear translocation of the signal transducer and activator of transcription 6 (STAT6) in HeLa cells. We observed activation of STAT6 as early as 2 hr after infection with T. gondii by the nuclear translocation of fluorescence expressed from exogenously transfected pDsRed2-STAT6 plasmid and by the detection of phosphotyrosine-STAT6 in Western blot. STAT6 activation occurred only by infection with live tachyzoites but not by co-culture with killed t

ParasitologyImmunology and Microbiology

Research Areas

ParasitologyDermatologyPsychiatry and Mental healthPhysiologyEpidemiologyMolecular Biology

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