Byoung Jae Kim
Seoul National University · 医学
研究室紹介
Professor Byoung Jae Kim's research lab focuses on translational biomedical research with a strong emphasis on regenerative medicine, maternal-fetal medicine, and oncology. The lab investigates mesenchymal stem cells from Wharton’s jelly for regenerative applications, explores the impact of maternal conditions such as preterm prelabor rupture of membranes and fatty liver disease on neonatal outcomes, and examines the tumor microenvironment’s role in drug resistance, particularly in targeted cancer therapies. The lab integrates clinical observations with molecular mechanisms to identify biomarkers and develop strategies for improved patient outcomes.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Wharton's jelly is not only one of the most promising tissue sources for mesenchymal stem cells (MSCs) but also a source of natural growth factors. To prove that we can get both natural growth factors and MSCs from Wharton's jelly, we compared cellular characteristics and the level of basic fibroblast growth factor (bFGF) from samples using the explant culture method to those derived from the traditional enzymatic culture method. The levels of bFGF were 27.0 ± 11.7 ng/g on day 3, 15.6 ± 11.1 ng/
본 연구는 최근에 많은 연구가 진행되어지고 있는 소비자-브랜드 관계에 대해 보다 심층적으로 살펴보았다. 본 연구에서는 소비자-브랜드 관계 형성에 영향을 미치는 소비자 특성을 관계 마케팅적인 관점에서 살펴보고 소비자-브랜드 관계 형성에 미치는 주요 영향요인들을 도출하였다. 또한 이런 요인들에 영향받아 형성된 소비자-브랜드 관계가 기업의 마케팅 성과에 어떤 영향을 주는가를 살펴보았다. 구체적으로 본 연구에서는 소비자의 관여도, 대인관계지향성, 관계마케팅에 대한 태도 등의 소비자 특성 변수가 소비자-브랜드 관계 형성에 영향을 미치고, 형성된 소비자-브랜드 관계 구축의 성과로써 재구매 의도와 긍정적 구전 활동이 강화될 수 있다는 연구 모델을 구성하고 이를 실증연구를 통해서 살펴보았다. 실증 결과, 소비자의 관여도와 관계 마케팅에 대한 태도가 소비자-브랜드 관계 형성에 긍정적 영향을 미친다는 것을 확인할 수 있었고, 이렇게 형성된 소비자-브랜드 관계가 재구매 의도와 긍정적 구전 활동을 높인다
BACKGROUND: The objective of this study was to determine whether acute histologic chorioamnionitis is associated with adverse neonatal outcomes in late preterm infants who were born after preterm PROM. METHODOLOGY/PRINCIPAL FINDINGS: The relationship between the presence of acute histologic chorioamnionitis and adverse neonatal outcome was examined in patients with preterm PROM who delivered singleton preterm newborns between 34 weeks and 36 6/7 weeks of gestation. Nonparametric statistics were
The presence of Grade 2-3 steatosis on ultrasound in early pregnancy was associated with the increased risk of delivering an LGA infant, even after adjustment for multiple confounding factors including GDM. Adiponectin may be the linking biomarker between NAFLD and LGA.
Drug resistance is a major impediment in medical oncology. Recent studies have emphasized the importance of the tumour microenvironment (TME) to innate resistance, to molecularly targeted therapies. In this study, we investigate the role of TME in resistance to cixutumumab, an anti-IGF-1R monoclonal antibody that has shown limited clinical efficacy. We show that treatment with cixutumumab accelerates tumour infiltration of stromal cells and metastatic tumour growth, and decreases overall surviva
1) The rate of RDS is greater following "indicated" rather than spontaneous preterm birth; 2) This observation supports the view that spontaneous preterm labor is adaptive in nature.
Most cases of ruptured ovarian cysts with hemoperitoneum can be managed conservatively. A low diastolic blood pressure and a large amount of hemoperitoneum suggest the need for surgical intervention.
Preeclampsia is one of the most serious complications during pregnancy, defined as development of hypertension during late pregnancy affecting other organ systems (proteinuria, thrombocytopenia, renal insufficiency, liver involvement, cerebral symptoms or pulmonary edema). Preeclampsia is known to be associated with significant dyslipidemia, but the cause or mechanism of this metabolic aberration is not clear. Quantitative analysis of cholesterol precursors and metabolites can reveal metabolic s
Patients with preterm labor and oligohydramnios are at increased risk for impending preterm delivery and intra-amniotic inflammation and, therefore, may benefit from careful surveillance.