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Chang-hee Lee

Korea University · 医学

研究室紹介

Professor Chang-hee Lee's research lab specializes in abdominal and musculoskeletal radiology, with a strong focus on advanced MRI techniques for non-invasive diagnosis and characterization of liver diseases, including non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). The lab develops multiparametric MRI biomarkers—such as diffusion-weighted imaging, perfusion parameters, and hepatobiliary phase imaging—to improve diagnostic accuracy and predict treatment response. A key research direction involves understanding the role of immune modulation, particularly through TAM receptor tyrosine kinases in macrophage function, linking radiological findings with underlying immunological mechanisms. The lab also investigates anatomical landmarks and morphological features for improved spinal and vascular imaging interpretation.

MRI biomarkersliver fibrosisnon-alcoholic steatohepatitishepatocellular carcinomaTAM receptors

Research Overview

Papers
218
Total Citations
2,491
Papers (5y)
41
Primary Field
医学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
41total
2022
2023
2024
2025
2026
Citations per year (5y)
168total
20222023202420252026

Selected Papers

15
1
Article|66 citations·2011
Perfluorooctanoic acid-induced inhibition of placental prolactin-family hormone and fetal growth retardation in mice
Chun Hui Suh, Nam Kyoo Cho, Chae Kwan Lee, Chang Hee Lee, Dae Hwan Kim, Chang Hee Lee, Byung Chul Son, Jong-Tae Lee, Byung Chul Son, Jong-Tae Lee
SJR Q1Molecular and Cellular Endocrinology
Environmental ChemistryEnvironmental Science
2
Article|54 citations·2007
Identification and prediction of transitional vertebrae on imaging studies: Anatomical significance of paraspinal structures
Chang Hee Lee, Cheol Min Park, Kyeong Ah Kim, Suk‐Joo Hong, Hae Young Seol, Baek Hyun Kim, Jung Hyuk Kim
SJR Q1Clinical Anatomy

The aim of our study was to examine the locational distribution of paraspinal structures on MRI and to determine any predictable parameters that may be used for the identification of transitional vertebra (TV). We enrolled 534 patients who underwent MRI of their lumbosacral spine. The locations of the paraspinal structures, such as aortic bifurcation (AB), IVC confluence (IC), right renal artery (RRA), celiac trunk (CT), SMA root (SR), and iliolumbar ligament (ILL), were determined using "cross

Pathology and Forensic MedicineMedicine
3
Article|53 citations·2010
Paradoxical high signal intensity of hepatocellular carcinoma in the hepatobiliary phase of Gd-EOB-DTPA enhanced MRI: initial experience
Seun Ah Lee, Chang Hee Lee, Woon Yong Jung, Jongmee Lee, Jae Woong Choi, Kyeong Ah Kim, Cheol Min Park
SJR Q2Magnetic Resonance Imaging
HepatologyMedicine
4
Article|52 citations·2006
Usefulness of standard deviation on the histogram of ultrasound as a quantitative value for hepatic parenchymal echo texture; preliminary study
Chang Hee Lee, Jae Woong Choi, Kyeong Ah Kim, Tae Seok Seo, Jong Mee Lee, Cheol Min Park
SJR Q1Ultrasound in Medicine & Biology
EpidemiologyMedicine
5
Article|44 citations·2020
Multiparametric MR Index for the Diagnosis of Non-Alcoholic Steatohepatitis in Patients with Non-Alcoholic Fatty Liver Disease
Jeong Woo Kim, Young‐Sun Lee, Yang Shin Park, Baek‐hui Kim, Soo Yeon Lee, Jong Eun Yeon, Chang Hee Lee
SJR Q1Scientific ReportsOA

Non-alcoholic steatohepatitis (NASH) is a complex disease consisting of various components including steatosis, lobular inflammation, and ballooning degeneration, with or without fibrosis. Therefore, it is difficult to diagnose NASH with only one imaging modality. This study was aimed to evaluate the feasibility of magnetic resonance imaging (MRI) for predicting NASH and to develop a non-invasive multiparametric MR index for the detection of NASH in non-alcoholic fatty liver disease (NAFLD) pati

EpidemiologyMedicine
6
Article|43 citations·2014
Using intravoxel incoherent motion (IVIM) MR imaging to predict lipiodol uptake in patients with hepatocellular carcinoma following transcatheter arterial chemoembolization: A preliminary result
Yang Shin Park, Chang Hee Lee, Ji Hoon Kim, In Seong Kim, Berthold Kiefer, Tae Seok Seo, Kyeong Ah Kim, Cheol Min Park
SJR Q2Magnetic Resonance ImagingOA

Both AER derived from contrast enhanced MRI and D* values derived from IVIM-DWI for HCC were significantly higher in LGU than in LPU. These parameters would be helpful for predicting the lipiodol uptake.

Radiology, Nuclear Medicine and ImagingMedicine
7
Review|41 citations·2012
Paradoxical uptake of Gd-EOB-DTPA on the hepatobiliary phase in the evaluation of hepatic metastasis from breast cancer: is the “target sign” a common finding?
Su‐Min Ha, Chang Hee Lee, Baek Hui Kim, Yang Shin Park, Jongmee Lee, Jae Woong Choi, Kyeong Ah Kim, Cheol Min Park
SJR Q2Magnetic Resonance Imaging
Radiology, Nuclear Medicine and ImagingMedicine
8
Article|40 citations·2013
Using Gd-EOB-DTPA-enhanced 3-T MRI for the differentiation of infiltrative hepatocellular carcinoma and focal confluent fibrosis in liver cirrhosis
Yang Shin Park, Chang Hee Lee, Baek‐hui Kim, Jongmee Lee, Jae Woong Choi, Kyeong Ah Kim, Jeong Hwan Ahn, Cheol Min Park
SJR Q2Magnetic Resonance ImagingOA

HBP improved the imaging characteristics of infiltrative HCC, allowing it to be distinguished from focal CF. Infiltrative HCC showed lower ADC values than focal CF. Lobular configuration, contour bulging, enhancement pattern, associated satellite nodules and portal vein thrombosis were still found to be highly suggestive MR findings for infiltrative HCC.

EpidemiologyMedicine
9
Article|37 citations·2019
Anti-Inflammatory Role of TAM Family of Receptor Tyrosine Kinases Via Modulating Macrophage Function
이창희, 전태훈
http://www.molcells.org/journal/view.html?doi=10.14348/molcells.2018.0419

Macrophage is an important innate immune cell that not only initiates inflammatory responses, but also functions in tissuerepair and anti-inflammatory responses. Regulating macrophage activity is thus critical to maintain immune homeostasis. Tyro3, Axl, and Mer are integral membrane proteins that constitute TAM family of receptor tyrosine kinases (RTKs). Growing evidence indicates that TAM family receptors play an important role in anti-inflammatory responses through modulating the function of m

10
Article|30 citations·2012
Gadoxetic acid-enhanced 3.0T MRI for the evaluation of hepatic metastasis from colorectal cancer: Metastasis is not always seen as a “defect” on the hepatobiliary phase
Aram Kim, Chang Hee Lee, Baek‐hui Kim, Jongmee Lee, Jae Woong Choi, Yang Shin Park, Kyeong Ah Kim, Cheol Min Park
SJR Q1European Journal of Radiology
HepatologyMedicine
11
Article|28 citations·2016
The Short Breath-Hold Technique, Controlled Aliasing in Parallel Imaging Results in Higher Acceleration, Can Be the First Step to Overcoming a Degraded Hepatic Arterial Phase in Liver Magnetic Resonance Imaging
Jung Lim Yoo, Chang Hee Lee, Yang Shin Park, Jeong Woo Kim, Jongmee Lee, Kyeong Ah Kim, Hae Young Seol, Cheol Min Park
SJR Q1Investigative Radiology

OBJECTIVE: The aim of this study was to assess whether a short breath-hold technique can improve hepatic arterial phase (HAP) image quality in gadoxetic acid-enhanced magnetic resonance (MR) imaging compared with a conventional long breath-hold technique. MATERIALS AND METHODS: Institutional review board approval and patient consent were obtained for this prospective randomized control study. One hundred nineteen patients undergoing gadoxetic acid-enhanced MR imaging were randomly assigned to gr

HepatologyMedicine
12
Review|27 citations·2010
Hepatic tumor response evaluation by MRI
Chang Hee Lee, Larissa Braga, Rafael O.P. de Campos, Richard C. Semelka
SJR Q1NMR in Biomedicine

Noninvasive evaluation of hepatic tumor response is necessary to improve the survival rate and quality of life of cancer patients. Among radiologic imaging modalities, MRI plays a significant role in the management of patients with hepatic tumor and is crucial for diagnosis, treatment planning and assessment of response or recurrence, because of its high contrast resolution, lack of ionizing radiation and the possibility of performing functional imaging sequences. This review provides an overvie

HepatologyMedicine
13
Article|27 citations·2022
The spectrum of magnetic resonance imaging proton density fat fraction (MRI-PDFF), magnetic resonance spectroscopy (MRS), and two different histopathologic methods (artificial intelligence vs. pathologist) in quantifying hepatic steatosis
Jeong Woo Kim, Chang Hee Lee, Zepa Yang, Baek‐hui Kim, Young‐Sun Lee, Kyeong Ah Kim
SJR Q2Quantitative Imaging in Medicine and SurgeryOA

Since MRS and MRI-PDFF demonstrated a strong correlation with each other and with the two different histopathologic methods, they can be used as an alternative noninvasive reference standard in nonalcoholic fatty liver disease (NAFLD) patients. However, these preliminary results should be interpreted with caution until they are validated in further studies.

EpidemiologyMedicine
14
Article|26 citations·2007
CT Colonography of pneumatosis cystoides intestinalis
Kyoung Min Kim, Chang Hee Lee, Kyeong Ah Kim, Cheol Min Park
Abdominal Imaging
SurgeryMedicine
15
Article|26 citations·2016
Washout appearance in Gd‐EOB‐DTPA‐enhanced MR imaging: A differentiating feature between hepatocellular carcinoma with paradoxical uptake on the hepatobiliary phase and focal nodular hyperplasia‐like nodules
Jeong Woo Kim, Chang Hee Lee, Soo Byn Kim, Bit Na Park, Yang Shin Park, Jongmee Lee, Cheol Min Park
SJR Q1Journal of Magnetic Resonance ImagingOA

Purpose To identify the most reliable imaging features for differentiating hepatocellular carcinoma with paradoxical uptake on the hepatobiliary phase (HCC para ) from focal nodular hyperplasia (FNH)‐like nodules using Gd‐EOB‐DTPA‐enhanced MRI. Materials and Methods This was a retrospective study. Twenty patients with HCC para and 21 patients with FNH‐like nodules were included. The following MRI features were evaluated using 3.0 Tesla unit by two radiologists: signal intensity (SI) on T1‐, T2‐,

HepatologyMedicine

Research Areas

SurgeryEpidemiologyHepatologyRadiology, Nuclear Medicine and ImagingOncologyObstetrics and Gynecology

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