Chang-Hwan Kim
Yonsei University · 医学
研究室紹介
Professor Chang-Hwan Kim's research lab focuses on the immunological crosstalk between host immunity and microbial metabolites, with a central emphasis on how microbial-derived signals—particularly short-chain fatty acids and other metabolites—regulate T cell differentiation, function, and homeostasis. The lab investigates the roles of chemokine receptors and their ligands in directing T cell migration, polarization, and localization within lymphoid tissues, especially in germinal centers and during immune responses. A key direction involves identifying molecular markers and signaling pathways that define specialized T helper subsets, such as germinal center T follicular helper cells and type 1 T cells, and understanding their functional specialization in immunity and tolerance. The lab also explores how microbial metabolites engage host receptors (e.g., GPRs, AhR, FXR) to modulate immune cell behavior in health and disease.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15BACKGROUND: Physical activity greatly affects human physical and mental health. This study investigated the effect of college students' physical activity levels on depression and personal relationships. METHODS: Participants were 525 college students from five Korean cities. The International Physical Activity Questionnaire, Beck's Depression Inventory, and Leary's interpersonal orientation paper test measured physical activity volume, depression, and interpersonal relationships, respectively. D
Sport center managers are likely to maximize member satisfaction by developing products or services that are tailored to the different groups of sport center members. A necessary step, then, is to identify different segments of sport center members. This study attempts to identify sport center segments in Seoul, Korea, as determined by the members' attitudes toward 33 service items. A 2-stage cluster analysis approach in which the Ward's minimum variance method is used at the first stage and the
AIMS: Peripheral arterial disease (PAD) is associated with morbidity and mortality, comprising a significant percentage of amputations. As it affects the quality of life of patients with PAD, it is an important health issue. Therefore, the risk factors affecting the outcomes of limb salvage after revascularization should be well investigated. The aim of this review is to summarize risk factors of amputation-free survival (AFS) after interventions targeting patients with PAD to develop evidence-b
Patients with end-stage liver disease undergo repetitive patterns of recovery and deterioration and are burdened with uncertainty. Although quality of life is low in patients with end-stage liver disease and their family members, few studies have been conducted to identify what palliative care should be provided for them. This integrative review aimed to explore palliative care for patients with end-stage liver disease, focusing on the components and outcome measurements for further research. Af
BACKGROUND: Based on a previous study on the feasibility of TomoEQA, an exit detector-based patient-specific pre-treatment quality assurance (QA) method for helical tomotherapy, an in-depth clinical evaluation was conducted. METHODS: Data of one hundred patients were analyzed to evaluate the clinical usefulness of TomoEQA for patient-specific pre-treatment QA in comparison with the conventional phantom-based method. Additional investigations were also performed under unusual measurement conditio
As the conventional method of geometric calibration not only needs extra-scan but also have the vulnerability to the dimensional accuracy of the dedicated phantom, we proposed a new geometric calibration scheme based on data redundancy which uses projection data of any arbitrary patient already scanned, mainly focused on a geometry of Varian’s OBI system. Using the fan-beam based data redundancy which can be applied to cone-beam projection data of either full-fan or half-fan geometry, one could
Objective: To analyse the sites of medical information by popular search engines and its appropriateness as guidance to medical information. Method: The search phrase carpal tunnel syndrome (CTS) and stroke were entered into four commonly used Korean web search engines. 24 and 21 web-sites from search engines were gathered, respectively. These web sites then were evaluated for authorship, content, and an informational value score was assigned to each. Results: According to authorship in CTS, 16.
This paper proposes a Wake-Up Receiver (WuRx) with two Architecture: Tuned-RF Receiver and Direct RF Detection Receiver. The proposed WuRx is designed in CMOS 65nm process and operates at VDD 0.8V and consumes 90uW and 4.5uW, respectively. At the operating frequency of 920MHz, the Receiver achieves a -60dBm/-70dBm Sensitivity [10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> bit error rate(BER)] at a data rate of 200 kbps.
본 논문은 아프리카 마다가스카르의 의료 인력 부족과 기본 외과 수술 접근성의 제약 문제를 해결하기 위해 시행된 지구병원 기본 외과 의사 양성 프로그램을 소개한다. 2017년부터 기획되어 2023~2024년 실행된 본 사업은 한국의 정부 및 비정부 기관 (KOICA, AFF, WELL International, 한국누가회 등)과 마다가스카르 보건부 및 국립보건원 (INSPC)의 협력으로 추진되었다. 마다가스카르 정부 소속 현지 공무원 의사 20명을 선발해 2년간 7가지 핵심 외과술기 중심의 훈련을 시행하고, 이후 5년간 비수도권 지구병원에 배치함으로써 약 500만 명의 주민에게 외과 진료 접근성을 제공하였다. 마다가스카르 정부의 급여 지원과 제도화 의지는 이 프로그램의 효과 및 지속 가능성을 보여주는 성과이다. 본 프로그램은 선교적 가치에 기반한 현지인 역량 강화형 의료선교 모델로, 향후 사업의 확대와 유사한 환경의 저개발국에서 적용 가능한 보건의료 인력개발 전략의 하나로서 그 가능성
우리나라와 같이 일본도 지리학과 지리교육의 위상이 매우 낮아지고 있다. 그러나 일본은 일본지리학회를 중심으로 지리학의 위상을 높이기 위한 여러 방안을 모색하고 있다. 그 중 하나가 ‘지역조사사’ 제도이다. 본 연구는 전문화와 지역에 대한 종합적 분석능력이 중요한 지리학의 사회적 위상을 높이고 사회공헌을 할 수 있는 방법을 찾으려고 한다. 그 사례로 일본에서 시행되고 있는 ‘지역조사사’ 제도에 관한 내용을 살펴보고, 이것이 우리나라 지리학계나 사회에서 활용할 수 있는 가능성을 모색하는 것이 본 연구의 목적이다. 일본에서 시행되고 있는 지역조사사 자격 제도는 ‘지역조사사’와 ‘전문지역조사사’로 구분되며, 자격취득을 위해서는 일본지리학회로부터 인정을 받은 소정의 과목을 이수해야만 된다. 이 제도는 지리학을 사회에 인지시키고 사회와 교류할 수 있는 교두보 역할을 담당할 수 있다고 생각된다. 따라서 우리나라 입장에서도 이 제도를 충분히 검토해 볼 가치가 있다고 판단된다. 우리나라도 지리학 관
Urticaria is classified as Eunjin in Oriental Medicine. The intrinsic causes include digestive system disorder, food poison, parasite, female reproductive health problem, nervous breakdown, and disorder of endocrine hormone. The extrinsic sources include all kinds of insect bites or stings, medications, pollen, dirt, and toxic smells. Some unknown sources also produce urticaria. The urticaria that lasts for more than six weeks, is categorized as chronic urticaria which is not very different from