Choi Sang-hyun
Korea University · 神経科学
研究室紹介
Professor Choi Sang-hyun's research lab focuses on the neurobiological mechanisms underlying energy balance, neurogenesis, and metabolic regulation in the central nervous system. Key research directions include the role of brain-derived neurotrophic factor (BDNF) in adult hippocampal neurogenesis and stress-related disorders, the central actions of metabolic drugs like metformin and nicotine on appetite and energy homeostasis, and the regulation of localized mRNA translation in neuronal compartments. The lab employs a multidisciplinary approach combining behavioral analysis, molecular biology, and neuroendocrinology to explore how neural circuits and signaling pathways in the hypothalamus and hippocampus contribute to obesity, depression, and metabolic disease.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15The regulated translation of localized mRNAs in neurons provides a mechanism for spatially restricting gene expression in a synapse-specific manner. To identify the population of mRNAs present in distal neuronal processes of rodent hippocampal neurons, we grew neurons on polycarbonate filters etched with 3 microm pores. Although the neuronal cell bodies remained on the top surface of the filters, dendrites, axons, and glial processes penetrated through the pores to grow along the bottom surface
New-born cells continue to proliferate and survive to become mature granule cells in adult rat hippocampus. Although this process, known as neurogenesis, is inhibited by acute stress, it is not clear whether chronic stress affects neurogenesis. To determine whether chronic mild stress (CMS) influences neurogenesis in the adult rat hippocampus, male Sprague-Dawley rats were exposed to CMS and administered bromodeoxyuridine (BrdU) before or after CMS to observe the survival/differentiation or prol
New-born cells continue to proliferate and survive to become mature granule cells in adult rat hippo-campus. Although this process, known as neuro-whether chronic stress affects neurogenesis. To de-termine whether chronic mild stress (CMS) influ-ences neurogenesis in the adult rat hippocampus, male Sprague-Dawley rats were exposed to CMS and administered bromodeoxyuridine (BrdU) before or after CMS to observe the survival/differentiation or proliferation of new-born cells, respectively. In addit
These results suggest depot-specific differences in AT angiogenesis and a potential role in the susceptibility to diet-induced obesity.
Nicotine treatment has known to produce an inverse relationship between body weight and food intake in rodents. Present study determined the effect of repeated treatment with nicotine and withdrawal in control and obese mice,on: (1) body weight, caloric intake and energy expenditure;(2) hypothalamic neuropeptides mRNA expression; and (3)serum leptin. 21-week-old C57BL/6 mice (n = 65) received nicotine (3.0 mg/kg/day; 2 weeks) and saline (1 ml/kg/day;2 weeks) subcutaneously. Animals were given ei
Administration of metformin is known to reduce both body weight and food intake. Although the hypothalamus is recognized as a critical regulator of energy balance and body weight, there is currently no evidence for an effect of metformin in the hypothalamus. Therefore, we sought to determine the central action of metformin on energy balance and body weight, as well as its potential involvement with key hypothalamic energy sensors, including adenosine monophosphate-activated protein kinase (AMPK)