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Dong-Hoon Han

Korea Advanced Institute of Science and Technology · 医学

研究室紹介

Professor Dong-Hoon Han's research lab specializes in chemical engineering and biomedical applications, with a focus on reactive extraction processes for organic acid recovery—particularly lactic acid—using amine-based extractants like trioctylamine. The lab also investigates cardiac complications from electrical injuries and explores advanced critical care interventions such as extracorporeal membrane oxygenation (ECMO) and novel therapies for ischemia-reperfusion injury in myocardial infarction. Their work bridges chemical process engineering with clinical medicine, emphasizing mechanistic studies and translational applications in wound care and cardiovascular protection. The lab integrates experimental data with modeling to optimize separation processes and improve patient outcomes in critical care settings.

reactive extractioncardiac complicationsECMOischemia-reperfusion injurylactic acid recovery

Research Overview

Papers
90
Total Citations
666
Papers (5y)
17
Primary Field
医学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
17total
2022
2023
2024
2025
2026
Citations per year (5y)
44total
20222023202420252026

Selected Papers

15
1
Article|56 citations·2000
Separation characteristics of lactic acid in reactive extraction and stripping
Donghoon Han, Yeon Ki Hong, Won Hi Hong
SJR Q2Korean Journal of Chemical Engineering
Mechanical EngineeringEngineering
2
Article|37 citations·1996
Reactive Extraction of Lactic Acid with Trioctylamine/Methylene Chloride/n-Hexane
Donghoon Han, Won Hi Hong
SJR Q2Separation Science and Technology

Abstract The trioctylamine (TOA)/methylene chloride (MC)/n-hexane system was used as the extraction agent for the extraction of lactic acid. Curves of equilibrium and hydration were obtained at various temperatures and concentrations of TOA. A modified mass action model was proposed to interpret the equilibrium and the hydration curves. The reaction mechanism and the corresponding parameters which best represent the equilibrium data were estimated, and the concentration of water in the organic p

Mechanical EngineeringEngineering
3
Review|25 citations·2022
Review of History of Basic Principles of Burn Wound Management
Hyun‐Jin Kim, Seongmee Shin, Donghoon Han
SJR Q2MedicinaOA

Thermal energy is an essential and useful resource to humans in modern society. However, a consequence of using heat carelessly is burns. Burn injuries have various causes, such as exposure to flame, radiation, electrical, and chemical sources. In this study, we reviewed the history of burn wound care while focusing on the basic principles of burn management. Through this review, we highlight the need for careful monitoring and customization when treating burn victims at each step of wound care,

RehabilitationMedicine
4
Article|20 citations·1998
Water-Enhanced Solubilities of Lactic Acid in Reactive Extraction Using Trioctylamine/Various Active Diluents Systems
Donghoon Han, Won Hi Hong
SJR Q2Separation Science and Technology

ABSTRACT ABSTRACT Trioctylamine (TOA) was used as the extraction agent for reactive extraction in various active diluents. Equilibrium and hydration data for various active diluents were obtained in 0.6 M TOA systems. From these data we divided the active diluents used into three classes: active diluents containing chlorine atoms, carbon-bonded oxygen donor active diluents, and phosphorus-bonded oxygen donor active diluents. This classification was based on the characteristic groups of active di

Mechanical EngineeringEngineering
5
Article|14 citations·2019
Retrospective study of prognosis and relating factors of cardiac complications associated with electrical injuries at a single centre in Korea
Jae Hyuk Choi, Donghoon Han, Si‐Hyuck Kang, Chang‐Hwan Yoon, Jung Rae Cho, Dohern Kym
SJR Q1BMJ OpenOA

Objectives To date, no research has investigated the association between cardiac complication and electrical injury; hence, we aimed to assess the consequences and relating factors of cardiac complications from electrical injuries in South Korea. Design Retrospective single-centre study. Participants 721 patients who had electrical injury–related admission during 2007–2017. An electronic medical record system was used to extract records of patients admitted for electrical injury treatment. Resul

EpidemiologyMedicine
6
Article|11 citations·1998
Reactive extraction of lactic acid in a packed column
Donghoon Han, Won Hi Hong
SJR Q2Korean Journal of Chemical Engineering
Mechanical EngineeringEngineering
7
Article|8 citations·2021
Features of Patients Receiving Extracorporeal Membrane Oxygenation Relative to Cardiogenic Shock Onset: A Single-Centre Experience
Dong-Geum Shin, Sang-Deock Shin, Donghoon Han, Min-Kyung Kang, Seunghun Lee, Jihoon Kim, Jung Rae Cho, Kunil Kim, Seonghoon Choi, Namho Lee
SJR Q2MedicinaOA

Background and Objectives: Extracorporeal membrane oxygenation (ECMO) can be helpful in patients with cardiogenic shock associated with myocardial infarction, and its early use can improve the patient survival rate. In this study, we report a mortality rate-difference analysis that examined the time and location of shock occurrence. Materials and Methods: We enrolled patients who underwent ECMO due to cardiogenic shock related to myocardial infarction and assigned them to either a pre- or post-a

Biomedical EngineeringEngineering
8
Article|6 citations·2011
Decreasing Pattern in Perinatal Mortality Rates in Korea: In Comparison with OECD Nations
Donghoon Han, Kyung Suk Lee, Sung Hoon Chung, Yong‐Sung Choi, Won Ho Hahn, Ji Young Chang, Chong-Woo Bae
Korean Journal of Perinatology
Obstetrics and GynecologyMedicine
9
Article|6 citations·2022
Attenuation of ischemia–reperfusion injury by intracoronary chelating agent administration
Donghoon Han, Si‐Hyuck Kang, Chang‐Hwan Yoon, Tae‐Jin Youn, In‐Ho Chae
SJR Q1Scientific ReportsOA

Ischemia-reperfusion (IR) injury accelerates myocardial injury sustained during the myocardial ischemic period and thus abrogates the benefit of reperfusion therapy in patients with acute myocardial infarction. We investigated the efficacy of intracoronary ethylenediaminetetraacetic acid (EDTA) administration as an adjunctive treatment to coronary intervention to reduce IR injury in a swine model. We occluded the left anterior descending artery for 1 h. From the time of reperfusion, we infused 5

Pathology and Forensic MedicineMedicine
10
Article|5 citations·2020
Changes in serum serotonin levels in patients with acute coronary syndrome and stable angina undergoing percutaneous coronary intervention
Donghoon Han, Jae Hyuk Choi, Sehun Kim, Sang Min Park, Dong Geum Shin, Min‐Kyung Kang, Seonghoon Choi, Namho Lee, Jung Rae Cho
SJR Q3Journal of International Medical ResearchOA

OBJECTIVE: Activated platelets release serotonin, causing platelet aggregation and vasoconstriction. Serotonin levels were investigated in patients with acute coronary syndrome (ACS) and chronic stable angina (CSA) treated with percutaneous coronary intervention (PCI). METHODS: Consecutive patients undergoing PCI for either ACS or CSA were enrolled between July 2009 and April 2010. Patients were pre-treated with dual antiplatelet agents (aspirin and clopidogrel) before PCI. Serum serotonin level

Cardiology and Cardiovascular MedicineMedicine
11
Article|5 citations·2012
A case of partial trisomy 3p syndrome with rare clinical manifestations
Donghoon Han, Ji Young Chang, Woo In Lee, Chong-Woo Bae
Korean Journal of PediatricsOA

Partial trisomy 3p results from either unbalanced translocation or de novo duplication. Common clinical features consist of dysmorphic facial features, congenital heart defects, psychomotor and mental retardation, abnormal muscle tone, and hypoplastic genitalia. In this paper, we report a case of partial trisomy 3p with rare clinical manifestations. A full-term, female newborn was transferred to our clinic. She had cleft lip-plate, dysgenesis of the corpus callosum, patent ductus arteriosus, pul

Pediatrics, Perinatology and Child HealthMedicine
12
Article|3 citations·2018
Experiences of magnetic resonance imaging scanning in patients with pacemakers or implantable cardioverter-defibrillators
Donghoon Han, Si‐Hyuck Kang, Youngjin Cho, Il-Young Oh
SJR Q2The Korean Journal of Internal MedicineOA

BACKGROUND/AIMS: Despite the U.S. Food and Drug Adminstration approving a magnetic resonance imaging (MRI)-conditional pacemaker system in 2011, many physicians remain reluctant to perform MRI scanning in patients with cardiac implantable electronic devices. Herein, we aimed to evaluate the real-world safety of MRI in these patients. METHODS: This single-center retrospective study examined the interrogation data and outcomes of patients with pacemakers or implantable cardioverter defibrillators

Radiology, Nuclear Medicine and ImagingMedicine
13
Article|3 citations·2021
Vasodilator agents improve hemodialysis vascular access patency
Do Hyoung Kim, Donghoon Han, Jaehwan Kim, Hayne Cho Park, Young‐Ki Lee, Dong Geum Shin, Min‐Kyung Kang, Jung Rae Cho, Seonghoon Choi, Namho Lee
SJR Q3MedicineOA

ABSTRACT: Vascular access (VA) failure is an important problem for patients undergoing hemodialysis, and maintaining VA patency is challenging. In this study, we used a nationwide database to investigate the effects of nitrate, as a vasodilator, on VA failure in hemodialysis patients.We investigated the Korean insurance claims data of hemodialysis patients who underwent angioplasty for VA failure between January 2012 and December 2017. The patients were divided into 2 groups: those not receiving

Emergency Medical ServicesHealth Professions
14
Article|3 citations·2021
Complications associated with the Rotarex® wire in a patient with peripheral artery disease
Donghoon Han, D. Shin, Min‐Kyung Kang, Jung Rae Cho, Seonghoon Choi, Namho Lee, Jong‐Wook Lee, Yoon Haeng Cho
Clinical Case ReportsOA

Abstract The Rotarex ® device is used for thrombectomy as well as atherectomy in patients with PAD. It is important to carefully consider the wire position of the Rotarex ® device during the procedure. As possible as the wire should be located in a lesion‐free area.

SurgeryMedicine
15
Article|2 citations·2019
Comparison of patency between two different peripheral self-expandable stents, absolute Pro® versus complete SE® in femoropopliteal occlusive disease
Donghoon Han, Si‐Hyuck Kang, Sun-Hwa Kim, Chang‐Hwan Yoon, In‐Ho Chae
SJR Q3International Angiology

In this retrospective single-center study, ABS and COM showed no difference in clinical efficacy. Both stents can be effectively used for the endovascular intervention of femoropopliteal artery disease when it is necessary.

SurgeryMedicine

Research Areas

Pulmonary and Respiratory MedicineCardiology and Cardiovascular MedicineMechanical EngineeringSurgeryPhysiologyRadiology, Nuclear Medicine and Imaging

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