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Dong-hyun Lee

Yonsei University · 医学

研究室紹介

Professor Dong-hyun Lee's research lab specializes in nanomaterials-based drug delivery systems and tissue engineering, with a focus on developing functionalized gold nanoparticles for targeted therapeutic applications in orthopedics, oncology, and ophthalmology. The lab investigates bioactive molecules such as alendronate and baicalin, delivering them via nanocarriers like gold nanoparticles and cyclodextrin-conjugated systems to enhance efficacy and site-specificity. A key research direction involves designing injectable hydrogels and biodegradable scaffolds for regenerative medicine, particularly in bone and retinal tissue repair. The lab also contributes to ophthalmic surgery innovation, focusing on minimally invasive techniques for intraocular lens fixation and retinal membrane management.

gold nanoparticlesdrug deliverytissue engineeringbone regenerationophthalmic surgery

Research Overview

Papers
97
Total Citations
647
Papers (5y)
22
Primary Field
医学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
22total
2021
2022
2023
2024
2025
Citations per year (5y)
64total
20212022202320242025

Selected Papers

15
1
Article|38 citations·2020
MICROCYSTIC MACULAR EDEMA AND CYSTOID MACULAR EDEMA BEFORE AND AFTER EPIRETINAL MEMBRANE SURGERY
Dong Hyun Lee, Sung Eun Park, Christopher Seungkyu Lee
SJR Q1RetinaOA

PURPOSE: To investigate the types of intraretinal cysts that are associated with epiretinal membranes and to evaluate the effects of each type of intraretinal cyst on postoperative outcomes. METHODS: Retrospective, cross-sectional study design. Patients who underwent preoperative fluorescent angiography and epiretinal membrane surgery from February 2014 to May 2019 were included. Intraretinal cysts were subdivided into cystoid macular edema with angiographic leakage and microcystic macular edema

Radiology, Nuclear Medicine and ImagingMedicine
2
Article|31 citations·2015
SURGICAL OUTCOME OF SIMULTANEOUS INTRAOCULAR LENS RESCUE AND SUTURELESS INTRASCLERAL TUNNEL FIXATION OF DISLOCATED INTRAOCULAR LENSES
Min Kim, Dong Hyun Lee, Hyoung Jun Koh, Sung Chul Lee, Sung Soo Kim
SJR Q1RetinaOA

Simultaneous rescue and sutureless intrascleral haptic fixation of dislocated 3-piece IOLs using bimanual maneuvers is an effective, safe, and minimally invasive surgical method to rescue and fixate the dislocated IOL without further explant.

OphthalmologyMedicine
3
Article|31 citations·2015
COMPARISON OF SURGICAL OUTCOME OF 23-GAUGE AND 25-GAUGE MICROINCISION VITRECTOMY SURGERY FOR MANAGEMENT OF IDIOPATHIC EPIRETINAL MEMBRANE IN PSEUDOPHAKIC EYES
Min Kim, Yong Sik Park, Dong Hyun Lee, Hyoung Jun Koh, Sung Chul Lee, Sung Soo Kim
SJR Q1RetinaOA

Both 23-G and 25-G MIVS yielded comparable visual outcomes for surgical treatment of idiopathic epiretinal membrane in pseudophakic eyes. The 25-G MIVS was associated with faster visual recovery and less postoperative hypotony than 23-G surgery.

Radiology, Nuclear Medicine and ImagingMedicine
4
Article|22 citations·2012
Low ankle–brachial index is a predictive factor for initial severity of acute ischaemic stroke
Dong Hyun Lee, Jinkwon Kim, Hye Sun Lee, Myoung-Jin Cha, Young Dae Kim, Hyo Suk Nam, Chung Mo Nam, Ji Hoe Heo
SJR Q1European Journal of Neurology

BACKGROUND: A low ankle-brachial index (ABI) is predictive of peripheral arterial disease (PAD). For unknown reasons, patients with PAD demonstrate higher vascular mortality during follow-up than do those without. Initial stroke severity is a strong predictor of long-term outcome and may be different between patients with and without PAD. Thus, we investigated whether a low ABI was associated with severe stroke presentation. METHODS: We enrolled 1147 first-ever ischaemic stroke patients who unde

SurgeryMedicine
5
Article|19 citations·2018
Long-term Effect of Scleral Encircling on Axial Elongation
Dong Hyun Lee, Jong Wook Han, Sung Soo Kim, Suk Ho Byeon, Hyoung Jun Koh, Sung Chul Lee, Min Kim
SJR Q1American Journal of OphthalmologyOA
EpidemiologyMedicine
6
Article|19 citations·2015
Acute macular neuroretinopathy associated with systemic lupus erythematosus
Dong Hyun Lee, S. C. Lee, Min Kim
SJR Q2LupusOA

Acute macular neuroretinopathy (AMN) is a rare disorder that presents with abrupt visual change with wedge-shaped or flower-like lesions pointing towards the fovea. Ischemic insults to the retinal capillary plexus may be important for development of this disease. While many case reports have been published on AMN, none have described AMN in association with systemic lupus erythematosus (SLE). Here, we report a case of AMN associated with newly-diagnosed SLE. We speculate that in patients with lu

OphthalmologyMedicine
7
Article|15 citations·2017
Features of optical coherence tomography predictive of choroidal neovascularisation treatment response in pathological myopia in association with fluorescein angiography
Dong Hyun Lee, Hyun Goo Kang, Sung Chul Lee, Min Kim
SJR Q1British Journal of OphthalmologyOA

Background/Aims The aim of this study was to evaluate the usefulness of several optical coherence tomography (OCT) findings to estimate choroidal neovascularisation (CNV) activity in pathological myopia using fluorescein angiography (FA) as a reference. Methods This was a single-centre, retrospective study. The medical records of patients with active myopic CNV who received intravitreal bevacizumab treatment were reviewed. Parameters to monitor CNV activity were morphological features of CNV on

OphthalmologyMedicine
8
Article|14 citations·2017
Vitreous hemorrhage and Rhegmatogenous retinal detachment that developed after botulinum toxin injection to the extraocular muscle: case report
Dong Hyun Lee, Jinu Han, Sueng‐Han Han, Sung Chul Lee, Min Kim
SJR Q2BMC OphthalmologyOA

Sudden loss of vision after injection of botulinum toxin into the extraocular muscle may suggest a serious complication, and a prompt, thorough ophthalmic examination should be performed. If improvements are not observed, rapid surgical intervention is recommended to prevent additional complications.

NeurologyMedicine
9
Article|12 citations·2021
Changes in Treatment Patterns and Globe Salvage Rate of Advanced Retinoblastoma in Korea: Efficacy of Intra-Arterial Chemotherapy
Dong Hyun Lee, Jung Woo Han, Seung Min Hahn, Byung Moon Kim, Chuhl Joo Lyu, Sung Chul Lee, Dong Joon Kim, Christopher Seungkyu Lee
SJR Q1Journal of Clinical MedicineOA

(1) Background: To analyze changes in treatment patterns for advanced retinoblastoma over time and differences in globe salvage rates; (2) Methods: Retrospective, observational case-control study of 97 eyes of 91 patients with advanced retinoblastoma (Group D and E).; (3) Results: Patients were divided into two groups based on whether they were treated before or after intraarterial chemotherapy (IAC) was introduced in our center in 2010. Before 2010, primary treatment pattern was enucleation, wh

OphthalmologyMedicine
10
Review|11 citations·2019
Ophthalmologic Manifestation of Inflammatory Bowel Disease: A Review
Dong Hyun Lee, Jae Yong Han, Jae Jun Park, Jae Hee Cheon, Min Kim
SJR Q3Korean Journal of GastroenterologyOA

In patients with inflammatory bowel disease (IBD), ocular extraintestinal manifestations (EIM) are less common than EIM of other systems, but they are clinically important because they can lead to complications that can cause catastrophic damage to the visual acuity and ocular structure. Anterior uveitis and episcleritis are the most common ocular EIM. Involvement of the orbit, posterior segment, and optic nerve can also occur. A variety of treatments are available ranging from topical steroids

GeneticsBiochemistry, Genetics and Molecular Biology
11
Article|9 citations·2014
Identifiable Peripheral Retinal Lesions Using Ultra-Widefield Scanning Laser Ophthalmoscope and Its Usefulness in Myopic Patients
Dong Hyun Lee, Sung Soo Kim, Min Kim, Hyoung Jun Koh
SJR Q4Journal of the Korean Ophthalmological SocietyOA

Purpose: To investigate identifiable peripheral retinal lesions in patients with myopia or high myopia and to evaluate the usefulness of ultra-widefield scanning laser ophthalmoscope in retina clinic settings. Methods: We evaluated fundus images of 149 patients acquired using an ultra-widefield scanning laser ophthalmoscope.

EpidemiologyMedicine
12
Article|9 citations·2019
Surgical outcome and prognostic factors influencing visual acuity in myopic foveoschisis patients
Dong Hyun Lee, Inhee Moon, Hyun Goo Kang, Eun Young Choi, Sung Soo Kim, Suk Ho Byeon, Hyoung Jun Koh, Sung Chul Lee, Min Kim
SJR Q1EyeOA
Radiology, Nuclear Medicine and ImagingMedicine
13
Article|8 citations·2022
Clinical features and long-term treatment outcome of posterior scleritis
Dong Hyun Lee, Hyuna Cho, Eun Young Choi, Min Kim
Annals of Translational MedicineOA

Most posterior scleritis patients were of non-infectious type and some needed additional immunosuppressive treatment. In patients with a history of ocular surgery or trauma, especially with the presence of pus-containing nodules, infectious posterior scleritis should always be considered. Since impaired vision does not improve significantly after treatment of posterior scleritis, prompt diagnosis and aggressive treatment are recommended.

OphthalmologyMedicine
14
Article|6 citations·2020
Uveal Effusion Associated with Presumed Viral Encephalitis
Dong Hyun Lee, Tae Young Kim, Sung Chul Lee, Min Kim
SJR Q2Ocular Immunology and InflammationOA

ADEM: Acute disseminated encephalomyelitis; BCVA: Best corrected visual acuity; CSF: Cerebrospinal fluid; CT: Computed tomography; MRI: Magnetic resonance imaging; WBC: White blood cell.

GeneticsBiochemistry, Genetics and Molecular Biology
15
Article|3 citations·2021
Clinical features and long-term treatment outcomes in choroidal tuberculoma
Dong Hyun Lee, Hyuna Cho, Junwon Lee, Eun Young Choi, Sung Chul Lee, Min Kim
SJR Q1Graefe s Archive for Clinical and Experimental OphthalmologyOA
OphthalmologyMedicine

Research Areas

OphthalmologyRadiology, Nuclear Medicine and ImagingSurgeryEpidemiologyMaterials ChemistryNeurology

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