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Dong Sup Lee

Seoul National University · 医学

研究室紹介

Professor Dong Sup Lee's research lab focuses on infectious diseases, particularly antibiotic-resistant urinary tract infections caused by *Escherichia coli*, with an emphasis on understanding resistance mechanisms, clinical management, and prevention strategies. The lab also investigates the impact of lifestyle and physiological factors—such as sleep deprivation and hormonal changes—on urological and sexual health. Additionally, the lab applies econometric methods, including hedonic pricing models, to study the economic value of urban environmental features like access to parks on housing prices. Overall, the lab bridges clinical microbiology, urology, endocrinology, and health economics to address public health challenges.

antibiotic resistanceurinary tract infectionssleep deprivationprostate healthhousing economics

Research Overview

Papers
139
Total Citations
1,747
Papers (5y)
26
Primary Field
医学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
26total
2022
2023
2024
2025
2026
Citations per year (5y)
75total
20222023202420252026

Selected Papers

15
1
Review|202 citations·2018
Community-Acquired Urinary Tract Infection byEscherichia coliin the Era of Antibiotic Resistance
Dong Sup Lee, Seung‐Ju Lee, Hyun‐Sop Choe
SJR Q2BioMed Research InternationalOA

Urinary tract infections (UTIs) caused by Escherichia coli (E. coli) are the most common types of infections in women. The antibiotic resistance of E. coli is increasing rapidly, causing physicians to hesitate when selecting oral antibiotics. In this review, our objective is to ensure that clinicians understand the current seriousness of antibiotic-resistant E. coli , the mechanisms by which resistance is selected for, and methods that can be used to prevent antibiotic resistance.

EpidemiologyMedicine
2
Article|72 citations·2017
Park Accessibility Impacts Housing Prices in Seoul
Jin-Han Park, Dong Sup Lee, Chan Park, Ho Kim, Tae Young Jung, Songyi Kim
SJR Q1SustainabilityOA

Housing prices are determined by a variety of factors, including the features of the building and the neighborhood environment, and a potential buyer decides to buy a house after reviewing these factors and concluding that it is worth the price. We used Hedonic Price Methods to find the relationship between monetary value of house and access conditions to urban parks. Two meaningful results were discovered in this study: first, as the distance from the park increases, the value of the park inher

TransportationSocial Sciences
3
Article|60 citations·2016
Acute bacterial prostatitis and abscess formation
Dong Sup Lee, Hyun‐Sop Choe, Hee Youn Kim, Sun Wook Kim, Sangrak Bae, Byung Il Yoon, Seung‐Ju Lee
SJR Q2BMC UrologyOA

BACKGROUND: The purpose of this study was to identify risk factors for abscess formation in acute bacterial prostatitis, and to compare treatment outcomes between abscess group and non-abscess group. METHODS: This is a multicenter, retrospective cohort study. All patients suspected of having an acute prostatic infection underwent computed tomography or transrectal ultrasonography to discriminate acute prostatic abscesses from acute prostatitis without abscess formation. RESULTS: A total of 31 pr

RheumatologyMedicine
4
Article|59 citations·2010
Prevalence and Risk Factors for Extended Spectrum Beta-Lactamase-Producing Uropathogens in Patients with Urinary Tract Infection
Dong Sup Lee, Chung Bum Lee, Seung-ju Lee
Korean journal of urologyOA

The overall prevalence of ESBL-producing microorganism was 12.6% and the risk appeared to be increased in cases with a previous hospitalization, a recent history of urinary catheterization, inpatient status, cefaclor medication, cefminox administration, and female gender.

EpidemiologyMedicine
5
Article|53 citations·2019
Impact of Sleep Deprivation on the Hypothalamic–Pituitary–Gonadal Axis and Erectile Tissue
Dong Sup Lee, Jong Bo Choi, Dong Wan Sohn
SJR Q1The Journal of Sexual Medicine

INTRODUCTION: It is unclear how sleep deprivation (SD) exerts a negative effect on men's health in terms of hypogonadism. AIM: To evaluate the hypothalamic-pituitary-gonadal (HPG) axis in subjects with SD and ultimately to evaluate the erectile tissue in response to the hormonal changes. METHODS: 56 male Wistar rats were used. First, 16 rats (16 weeks old) were subjected to 72 hours of SD, and the following were compared with 16 control rats: (i) levels of gonadotropin-releasing hormone (GnRH),

Reproductive MedicineMedicine
6
Article|49 citations·2016
Role of age and sex in determining antibiotic resistance in febrile urinary tract infections
Dong Sup Lee, Hyun‐Sop Choe, Hee Youn Kim, Je Mo Yoo, Woong Jin Bae, Yong Hyun Cho, Sun Wook Kim, Chang Hee Han, Sangrak Bae, Hoon Jang, Su Bum Park, Byung Il Yoon
SJR Q1International Journal of Infectious DiseasesOA

Age is not a considerable factor in determining the antibiotic resistance in febrile UTIs. Ciprofloxacin should be withheld from both sexes until culture results indicate its use. Second- or third-generation cephalosporins such as cefoxitin and cefotaxime can be used empirically only in females.

EpidemiologyMedicine
7
Article|44 citations·2013
Antimicrobial Susceptibility Pattern and Epidemiology of Female Urinary Tract Infections in South Korea, 2010-2011
Dong Sup Lee, Hyun‐Sop Choe, Sung Jong Lee, Woong Jin Bae, Hyeong Jun Cho, Byung Il Yoon, Yong‐Hyun Cho, Chang Hee Han, Hoon Jang, Su Bum Park, Won Jin Cho, Seung‐Ju Lee
SJR Q1Antimicrobial Agents and ChemotherapyOA

This study aimed to (i) investigate the antimicrobial susceptibilities of bacteria that cause urinary tract infections (UTIs) in outpatient and inpatient settings and (ii) evaluate the risk factors for emerging antimicrobial drug resistance in UTIs in South Korea. In total, 3,023 samples without duplication were collected from females between 25 and 65 years of age who had been diagnosed with a urinary tract infection. Multicenter patient data were collected using a Web-based electronic system a

EpidemiologyMedicine
8
Article|37 citations·2020
Critical causes in severe bleeding requiring angioembolization after percutaneous nephrolithotomy
Hee Youn Kim, Kyu Won Lee, Dong Sup Lee
SJR Q2BMC UrologyOA

BACKGROUND: To identify the risk factors for severe bleeding requiring angioembolization among patients who received transfusions after PCNL, particularly those who underwent anatomically incorrect renal puncture. METHODS: A total of 53 patients, who received transfusions after PCNL and simultaneously had a postoperative CT scan performed between November 2009 and May 2019 at two teaching hospitals, were retrospectively reviewed. The patients were divided into two groups: those who underwent ang

Pulmonary and Respiratory MedicineMedicine
9
Article|28 citations·2007
Porcine PD‐L1: cloning, characterization, and implications during xenotransplantation
Daehyun Jeon, Keunhee Oh, Byoung Chol Oh, Dong Hyun Nam, Chi-H. Kim, Hyung‐Bae Park, Jaejin Cho, Jeong Ryul Lee, Dong Sup Lee, Gene Lee
SJR Q2Xenotransplantation

BACKGROUND: Effective intervention achieved by manipulating cell-mediated xenogeneic immune responses would critically increase the clinical feasibility of xenotransplantation as immediate hyperacute rejections become controllable through genetic modulations of donor organs. Endogenous negative regulatory signals like the programmed death 1 (PD-1)-programmed death ligand 1 (PD-L1) system are candidate targets for the control of cell-mediated xenogeneic immune response. METHODS: A porcine PD-L1 m

SurgeryMedicine
10
Article|23 citations·2012
Biocompatibility of a PDMS-coated micro-device: Bladder volume monitoring sensor
Dong Sup Lee, Su Jin Kim, Jun Ho Sohn, In Gul Kim, Sae Woong Kim, Dong Wan Sohn, Jong Hyun Kim, Bumkyoo Choi, Jong Hyun Kim, Bumkyoo Choi
SJR Q1Chinese Journal of Polymer Science
SurgeryMedicine
11
Article|17 citations·2017
Multi-Objective Land-Use Allocation Considering Landslide Risk under Climate Change: Case Study in Pyeongchang-gun, Korea
Eun Joo Yoon, Dong Sup Lee, Ho Kim, Hae‐Yeong Kim, Eunah Jung, Heeyeun Yoon
SJR Q1SustainabilityOA

Extreme landslides triggered by rainfall in hilly regions frequently lead to serious damage, including casualties and property loss. The frequency of landslide occurrences may increase under climate change, due to the increasing variability of precipitation. Developing urban areas outside landslide risk zones is the most effective method of reducing or preventing damage; however, planning in real life is a complex and nonlinear problem. For such multi-objective problems, genetic algorithms may b

Management, Monitoring, Policy and LawEnvironmental Science
12
Article|15 citations·2011
Real‐time bladder volume monitoring by the application of a new implantable bladder volume sensor for a small animal model
Dong Sup Lee, Su Jin Kim, Su Jin Kim, Dong Wan Sohn, Bumkyoo Choi, Moon Kyu Lee, Seung Joon Lee, Sae Woong Kim, Sae Woong Kim
SJR Q2The Kaohsiung Journal of Medical SciencesOA

Although real-time monitoring of bladder volume together with intravesical pressure can provide more information for understanding the functional changes of the urinary bladder, it still entails difficulties in the accurate prediction of real-time bladder volume in urodynamic studies with small animal models. We studied a new implantable bladder volume monitoring device with eight rats. During cystometry, microelectrodes prepared by the microelectromechanical systems process were placed symmetri

UrologyMedicine
13
Article|15 citations·2013
Comparison of in vivo biocompatibilities between parylene-C and polydimethylsiloxane for implantable microelectronic devices
Dong Sup Lee, Su Jin Kim, Eun Bi Kwon, Cheol Whee Park, Su Min Jun, Bumkyoo Choi, Sae Woong Kim, Sae Woong Kim, Sae Woong Kim
SJR Q2Bulletin of Materials Science
Cellular and Molecular NeuroscienceNeuroscience
14
Article|11 citations·2020
Does deep sedation with analgesia have positive effects on anxiety, pain and compliance in patients before and after prostate biopsy?
Min Soo Choo, Dong Sup Lee
SJR Q2International Journal of Clinical Practice

AIMS: To investigate whether deep sedation for transrectal prostate biopsy could reduce anxiety and pain and enhance rebiopsy compliance. METHODS: A two-centre prospective observation study was conducted under two different anaesthetic conditions: deep sedation with analgesia and local anaesthesia with lidocaine. A 12-core prostate biopsy was taken in all patients. Scores on a 0-10 visual analogue scale, the State-Trait Anxiety Inventory-X-1, the Beck Anxiety Inventory and a five-level Likert sa

Pulmonary and Respiratory MedicineMedicine
15
Article|11 citations·2019
The Role of Antegrade Irrigation via Percutaneous Nephrostomy on Surgical Outcomes in Semirigid Ureteroscopy among Patients with Upper Ureteral Stones
Wonho Jung, Hye Jin Byun, Dong Sup Lee
SJR Q2BioMed Research InternationalOA

OBJECTIVE: We aimed to investigate the role of antegrade irrigation via percutaneous nephrostomy on surgical outcomes in retrograde ureteroscopy in patients with upper ureter stones. MATERIALS AND METHODS: In this retrospective study, we analyzed 134 patients who underwent retrograde semirigid ureteroscopy for upper ureter stones between August 2012 and December 2017. Patients were divided into two groups: retrograde irrigation group (conventional URS) and antegrade irrigation group (using percu

Pulmonary and Respiratory MedicineMedicine

Research Areas

Pulmonary and Respiratory MedicineUrologySurgeryEpidemiologyMicrobiologyPsychiatry and Mental health

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