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Dong‐Hyuk Cho

Korea University · 医学

研究室紹介

Professor Dong-Hyuk Cho's research lab specializes in cardiovascular and metabolic health, with a focus on the pathophysiology of heart failure, particularly the role of organ-specific adiposity such as epicardial adipose tissue in cardiac remodeling. The lab investigates the impact of lifestyle factors—like physical activity and statin use—on outcomes in infectious diseases (e.g., COVID-19) and postoperative complications. Using large-scale population-based cohorts and advanced imaging techniques (e.g., cardiac MRI and echocardiography), the lab explores biomarkers and risk prediction models for heart failure and cardiovascular events. Their work bridges clinical cardiology with preventive medicine and precision health strategies.

heart failureepicardial adipose tissuecardiac MRIstatinsphysical activity

Research Overview

Papers
94
Total Citations
918
Papers (5y)
65
Primary Field
医学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
65total
2022
2023
2024
2025
2026
Citations per year (5y)
438total
20222023202420252026

Selected Papers

15
1
Article|57 citations·2021
Physical Activity and the Risk of COVID-19 Infection and Mortality: A Nationwide Population-Based Case-Control Study
Dong‐Hyuk Cho, Sun Ju Lee, Sae Young Jae, Woo Joo Kim, Seong Jun Ha, Jun Gyo Gwon, Jimi Choi, Dong Wook Kim, Jang‐Young Kim
SJR Q1Journal of Clinical MedicineOA

Regular physical activity (PA) is known to reduce the risk of serious community-acquired infections. We examined the association of PA with the morbidity and mortality resulting from coronavirus disease (COVID-19) infection in the South Korean population. Patients who tested positive for severe acute respiratory coronavirus 2 and who underwent public health screening between 2014 and 2017 (n = 6288) were included. Age- and sex-matched controls (n = 125,772) were randomly selected from the Korean

PhysiologyMedicine
2
Article|49 citations·2013
Presence of Preoperative Diastolic Dysfunction Predicts Postoperative Pulmonary Edema and Cardiovascular Complications in Patients Undergoing Noncardiac Surgery
Dong‐Hyuk Cho, Seong‐Mi Park, Mi‐Na Kim, Sua Kim, Hae-Ja Lim, Wan‐Joo Shim
SJR Q3Echocardiography

OBJECTIVE: The aim of this study was to evaluate the impact of left ventricular diastolic dysfunction on predicting postoperative pulmonary edema and major cardiovascular events (MACE) in patients who underwent low- or intermediate-risk noncardiac surgery. METHODS: A total of 692 patients aged >60 years who underwent transthoracic echocardiography (TTE) before undergoing elective low- or intermediate-risk noncardiac surgery were prospectively enrolled. The medical history and TTE variables were

Cardiology and Cardiovascular MedicineMedicine
3
Article|32 citations·2024
Epicardial Adipose Tissue and Heart Failure, Friend or Foe?
Dong‐Hyuk Cho, Seong‐Mi Park
SJR Q1Diabetes & Metabolism JournalOA

Heart failure (HF) management guidelines recommend individualized assessments based on HF phenotypes. Adiposity is a known risk factor for HF. Recently, there has been an increased interest in organ-specific adiposity, specifically the role of the epicardial adipose tissue (EAT), in HF risk. EAT is easily assessable through various imaging modalities and is anatomically and functionally connected to the myocardium. In pathological conditions, EAT secretes inflammatory cytokines, releases excessi

Cardiology and Cardiovascular MedicineMedicine
4
Article|24 citations·2021
Myocardial Injury and Fibrosis From Acute Carbon Monoxide Poisoning
Dong‐Hyuk Cho, Sung Min Ko, Jung‐Woo Son, Eung Joo Park, Yong Sung
SJR Q1JACC. Cardiovascular imagingOA

The LGE prevalence in patients with acute CO poisoning with elevated TnI levels, with no underlying cardiovascular diseases and eligible for CMRI, was 69.2%; this proportion primarily comprised patients with a midwall injury. Of the 37 patients who underwent follow-up CMRI, most chronic phase images showed no interval change. Myocardial fibrosis detected on CMR images was related to acute myocardial dysfunction and subacute deterioration of myocardial strain on TTE. (Cardiac Magnetic Resonance I

Molecular BiologyBiochemistry, Genetics and Molecular Biology
5
Article|23 citations·2020
Risk of peripheral arterial disease in patients with periodontitis: A nationwide, population-based, matched cohort study
Dong‐Hyuk Cho, In‐Seok Song, Jimi Choi, Jun Gyo Gwon
SJR Q1Atherosclerosis
PeriodonticsDentistry
6
Article|22 citations·2020
Protective Effects of Statin and Angiotensin Receptor Blocker in a Rat Model of Doxorubicin- and Trastuzumab-Induced Cardiomyopathy
Dong‐Hyuk Cho, I-Rang Lim, Jong-Ho Kim, Mi‐Na Kim, Yong‐Hyun Kim, Kyong Hwa Park, Seong‐Mi Park, Wan Joo Shim
SJR Q1Journal of the American Society of Echocardiography
Cardiology and Cardiovascular MedicineMedicine
7
Article|22 citations·2021
Metabolic syndrome and the risk of COVID-19 infection: A nationwide population-based case-control study
Dong‐Hyuk Cho, Jimi Choi, Jun Gyo Gwon
SJR Q1Nutrition Metabolism and Cardiovascular DiseasesOA
Infectious DiseasesMedicine
8
Article|12 citations·2022
Atrial Cardiomyopathy with Impaired Functional Reserve in Patients with Paroxysmal Atrial Fibrillation
Dong‐Hyuk Cho, Yun Gi Kim, Jimi Choi, Hee‐Dong Kim, Mi‐Na Kim, Jaemin Shim, Jong‐Il Choi, Young‐Hoon Kim, Wan Joo Shim, Seong‐Mi Park
SJR Q1Journal of the American Society of Echocardiography
Cardiology and Cardiovascular MedicineMedicine
9
Article|11 citations·2022
Atorvastatin Reduces the Severity of COVID-19: A Nationwide, Total Population-Based, Case-Control Study
Dong‐Hyuk Cho, Jimi Choi, Jun Gyo Gwon
SJR Q3COVIDOA

Background: Statins have a pleiotropic effect in addition to a lipid-lowering effect. Several studies have demonstrated that statins may reduce the mortality and severity of infectious diseases, such as pneumonia or sepsis. We investigated the protective effects of various statins on the coronavirus disease 2019 (COVID-19) using a population-based cohort covering the entire Korean population. Methods: Consecutive patients diagnosed with COVID-19 between January 2020 and May 2020 were enrolled fr

Infectious DiseasesMedicine
10
editorial|8 citations·2020
COVID-19 — Implications for Patients with Heart Failure: The Korean Society of Heart Failure's Clinical Recommendations
Dong‐Hyuk Cho, Byung‐Su Yoo, Jung‐Woo Son, In‐Cheol Kim, Seong‐Mi Park, Dong‐Ju Choi
SJR Q1International Journal of Heart FailureOA
Cardiology and Cardiovascular MedicineMedicine
11
Article|8 citations·2024
Angiotensin Receptor-Neprilysin Inhibitor Adherence and Outcomes in Heart Failure with Reduced Ejection Fraction
Dong‐Hyuk Cho, Jimi Choi, Jong‐Chan Youn, Mi‐Na Kim, Chan Joo Lee, Jung‐Woo Son, Byung‐Su Yoo
SJR Q1ESC Heart FailureOA

AIMS: Whether medication adherence to angiotensin receptor-neprilysin inhibitor (ARNI) in real-world practice is associated with the reduced risk of all-cause mortality or hospitalization relative to that with traditional renin-angiotensin system (RAS) blockade remains unclear. This study investigated the influence of medication adherence of ARNI and traditional RAS blockade in heart failure with reduced ejection fraction (HFrEF). METHOD: We conducted a nationwide longitudinal cohort study with

Cardiology and Cardiovascular MedicineMedicine
12
Article|7 citations·2022
Temporal trends in heart failure over 11 years in the aging Korean population: A retrospective study using the national health insurance database
Dong‐Hyuk Cho, Chan Joo Lee, Jung‐Woo Son, Jimi Choi, Jinseub Hwang, Byung‐Su Yoo
SJR Q1PLoS ONEOA

BACKGROUND: Understanding national trends of heart failure (HF) is crucial for establishing prevention and treatment strategies. We aimed to investigate the 11-year trends of HF in the South Korean population. METHODS: Using the Korean National Health Insurance Service database, we identified 3,446,256 patients with HF between 2004 and 2014. RESULTS: The prevalence of HF was 1.42% in 2004, steadily increasing to 1.98% in 2014. However, the age-adjusted prevalence of HF remained stable (1.43% in

Cardiology and Cardiovascular MedicineMedicine
13
Review|7 citations·2024
Practical Recommendations for the Evaluation and Management of Cardiac Injury Due to Carbon Monoxide Poisoning
Dong‐Hyuk Cho, Stephen R. Thom, Jung‐Woo Son, Sung Min Ko, Yong Sung
SJR Q1JACC Heart Failure
Molecular BiologyBiochemistry, Genetics and Molecular Biology
14
Article|6 citations·2025
Longitudinal increase in physical activity and adverse cardiovascular outcomes following the diagnosis of acute coronary syndrome
Dong‐Hyuk Cho, Sae Young Jae, Setor K. Kunutsor, Jimi Choi, Jun Gyo Gwon
SJR Q1British Journal of Sports MedicineOA

OBJECTIVES: Physical activity (PA) provides protective effects against cardiovascular diseases, including ischaemic heart disease. However, recommending moderate to vigorous PA (MVPA) to patients with recent acute coronary syndrome (ACS) raises concerns owing to potential risk of recurrent ACS or fatal arrhythmias. This study investigated the association between longitudinal PA changes following an ACS diagnosis and subsequent cardiovascular outcomes, including non-fatal coronary events, non-fat

Cardiology and Cardiovascular MedicineMedicine
15
Article|5 citations·2021
Risk of acute and chronic coronary syndrome in a population with periodontitis: A cohort study
Jun Gyo Gwon, Jimi Choi, Seung Hyun Kim, Soo‐Ho Kim, Jae‐Jun Ryu, Dong‐Hyuk Cho, In‐Seok Song
SJR Q1Oral Diseases

OBJECTIVE: To investigate the role of periodontitis in the risk of acute and chronic coronary syndrome with compounding factors, including sociodemographic factors and medication use. METHODS: This retrospective cohort study used nationwide, population-based data from the Korean National Health Insurance Service-Health Screening Cohort database (514,866 individuals, 40-79 years). Propensity score matching was used for analysis. Information of subjects for 12 years was included. Socioeconomic and

PeriodonticsDentistry

Research Areas

Cardiology and Cardiovascular MedicineSurgeryPhysiologyEndocrinology, Diabetes and MetabolismMolecular BiologyInfectious Diseases

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