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Dongwook Son

Sungkyunkwan University · 医学

研究室紹介

Professor Dongwook Son's research lab focuses on regenerative medicine and tissue engineering, particularly in orthopedic applications such as meniscal allograft transplantation and ligament reconstruction. The lab also investigates natural compounds for dermatological and metabolic applications, including cinnamic acid's role in melanin regulation and Korean red ginseng's anti-fatigue effects. Additionally, environmental biotechnology is a key area, with studies on biological nitrogen removal using zeolite-based systems in industrial wastewater treatment. The lab integrates clinical outcomes, cellular mechanisms, and environmental sustainability across diverse biomedical and ecological challenges.

meniscal allograft transplantationnatural compoundsbiological nitrogen removaltissue engineeringclinical outcomes

Research Overview

Papers
34
Total Citations
437
Papers (5y)
11
Primary Field
医学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
11total
2021
2022
2023
2025
2026
Citations per year (5y)
32total
20212022202320252026

Selected Papers

15
1
Article|75 citations·2019
Long-term Outcomes of Meniscal Allograft Transplantation With and Without Extrusion: Mean 12.3-Year Follow-up Study
Sangmin Lee, Seong‐Il Bin, Jong‐Min Kim, Bum‐Sik Lee, Chang‐Rack Lee, Dong-Wook Son, Jun-Gu Park
SJR Q1The American Journal of Sports Medicine

BACKGROUND: Meniscal allograft transplantation (MAT) is a widely performed surgical technique used to reconstruct meniscal deficiencies after meniscectomy. However, the long-term effects of extrusion on clinical and radiologic outcomes are unclear. HYPOTHESIS: In long-term follow-up, extrusion after MAT would show poorer outcomes than nonextrusion and would lead to faster progression of arthritic changes. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: Forty-five MAT cases (lateral, n

SurgeryMedicine
2
Article|64 citations·2008
Inhibitory Effects of Cinnamic Acid on Melanin Biosynthesis in Skin
Yeon Hee Kong, Youn Ock Jo, Chang‐Won Cho, Dong-Wook Son, Soo‐Jin Park, Jeong-Hae Rho, Sang Yoon Choi
SJR Q2Biological and Pharmaceutical BulletinOA

Cinnamic acid is a wildly distributed phenylpropanoid component naturally occurring in plants, and is mainly found in Cinnamomum cassia BLUME and Panax ginseng. Cinnamic acid was recently reported to exert a tyrosinase inhibitory effect. However, research on melanocytes and animal bodies was not reported until now. In this study, we examined the effects of cinnamic acid on melanin biosynthesis within the melanocytes and brown guinea pigs. Melan-a cells were used to examine the effects of cinnami

Cell BiologyBiochemistry, Genetics and Molecular Biology
3
Article|45 citations·2004
Neuroprotective effect of wogonin in hippocampal slice culture exposed to oxygen and glucose deprivation
Dong-Wook Son, Pyeongjae Lee, Jongseok Lee, Hocheol Kim, Sun Yeou Kim
SJR Q1European Journal of Pharmacology
PharmacologyMedicine
4
Article|38 citations·2000
Nitrogen and organics removal from industrial wastewater using natural zeolite media
Y.-C. Chung, Dong-Wook Son, Dae‐Hee Ahn
SJR Q2Water Science & Technology

Biological removal of nitrogen from industrial wastewater was investigated by a novel O/A (oxic/anoxic) type process with natural zeolite circulation. This process consists of ammonium ion removal by zeolites and subsequent biological regeneration of zeolites. Two types of raw wastewater with high strength ammonia nitrogen (300–400 mg/L) from a fertilizer industry and a tannery industry, separately, were prepared for laboratory scale experiments. After ammonia ion removal from the influent waste

PollutionEnvironmental Science
5
Article|32 citations·2003
Alkaloid fraction of Uncaria rhynchophylla protects against N-methyl-d-aspartate-induced apoptosis in rat hippocampal slices
Jong-Seok Lee, Dong-Wook Son, Pyeongjae Lee, Sun Yeou Kim, Hocheol Kim, Chang‐Ju Kim, Eun-Hee Lim
SJR Q2Neuroscience Letters
PharmacologyPharmacology, Toxicology and Pharmaceutics
6
Article|25 citations·2020
Does Age Itself Have an Adverse Effect on Survivorship of Meniscal Allograft Transplantation? A Cartilage Status and Time From Previous Meniscectomy–Matched Cohort Study
Ju‐Ho Song, Seong‐Il Bin, Jong‐Min Kim, Bum‐Sik Lee, Dong-Wook Son
SJR Q1The American Journal of Sports Medicine

Background: The aging process is accompanied by several conditions that could affect the outcome of meniscal allograft transplantation (MAT). These conditions have made it difficult for clinicians to determine the effect of chronologic age on survivorship after MAT. Hypothesis: Advanced age does not have an adverse effect on survivorship of MAT when controlling for age-related factors, such as cartilage status and time from previous meniscectomy. Study Design: Cohort study; Level of evidence, 3.

SurgeryMedicine
7
Article|22 citations·2019
Safety and antifatigue effect of Korean Red Ginseng: a randomized, double-blind, and placebo-controlled clinical trial
Li Zhang, Xiaoyun Chen, Yanqi Cheng, Qilong Chen, Hongsheng Tan, Dong-Wook Son, Dongpill Chang, Zhaoxiang Bian, Hong Fang, Hong‐Xi Xu
SJR Q1Journal of Ginseng ResearchOA

Our study revealed that KRG has a potent antifatigue effect without significant adverse effects in people with deficiency syndrome. Although a larger sample size and longer treatment may be required for a more definite conclusion, this clinical trial is the first to disprove the common conception of "fireness" related to KRG.

Molecular BiologyBiochemistry, Genetics and Molecular Biology
8
Review|18 citations·2020
Comparison of femoral tunnel widening after anterior cruciate ligament reconstruction using cortical button fixation versus transfemoral cross-pin fixation: a systematic review and meta-analysis
Dae‐Hee Lee, Dong-Wook Son, Yi-Rak Seo, Ingyu Lee
SJR Q1Knee Surgery and Related ResearchOA

BACKGROUND: The aim was to compare tunnel widening of autogenous hamstring anterior cruciate ligament reconstruction (ACLR) using cortical button versus cross-pin femoral fixation. METHODS: The PubMed, Embase, and Cochrane Central Register of Controlled Trials databases were searched from inception to 11 April 2019. The study included all levels of evidence in studies that reported femoral tunnel widening and compared cortical button and cross-pin femoral fixation for ACLR. RESULTS: Six studies

SurgeryMedicine
9
Article|16 citations·2007
Protective Effect of (4-Methoxybenzylidene)-(3-methoxynophenyl)amine against Neuronal Cell Death Induced by Oxygen and Glucose Deprivation in Rat Organotypic Hippocampal Slice Culture
Sang Yoon Choi, Sanghee Kim, Dong-Wook Son, Pyeongjae Lee, Jongseok Lee, Sanghyun Lee, Dong Soo Kim, Yong‐Kon Park, Sun Yeou Kim
SJR Q2Biological and Pharmaceutical BulletinOA

Resveratrol (trans-3,4',5-trihydroxystilbene) is a natural phytoalexin found in grape skin, and has been suggested to be an antioxidant agent, an anticancer agent and a cardioprotective agent. In particular, recent experimental evidence has demonstrated that resveratrol exhibits neuroprotective effects in various assay systems. During the study on the resveratrol derivatives, we found that (4-methoxybenzylidene)-(3-methoxyphenyl)amine (MBMPA), which has blocked free phenolic groups, strongly pro

Geriatrics and GerontologyMedicine
10
Article|13 citations·2020
One‐Stage Anatomical Revision Anterior Cruciate Ligament Reconstruction: Results According to Tunnel Overlaps
Jin-Hwan Ahn, Dong-Wook Son, Hwa-Jae Jeong, Daewon Park, Ingyu Lee
SJR Q1Arthroscopy The Journal of Arthroscopic and Related Surgery

PURPOSE: To present clinical results according to tunnel overlap in 1-stage anatomical revision anterior cruciate ligament reconstruction (ACLR). METHODS: All patients who underwent revision ACLR performed by a single surgeon (J.H.A.) from 2012 to 2017 and were followed up for >24 months were retrospectively evaluated. The exclusion criteria were concomitant ligament injury, including medial collateral ligament injury, modified Outerbridge grade ≥3 cartilage lesion, and severe meniscus defects.

SurgeryMedicine
11
Article|11 citations·2005
Improvement of the thickening and dewatering characteristics of activated sludge by electroflotation (EF)
Younggyun Choi, H.S. Kim, Y.H. Park, Sanghyun Jeong, Dong-Wook Son, Yeom-Jae Oh, Ikjun Yeom
SJR Q2Water Science & Technology

The performances of electroflotation (EF) on the thickening of activated sludge were investigated using laboratory scale batch flotation reactors. Four activated sludges including bulking sludges were tested. After 30 minutes of EF operation, 57-84% of sludge volume reduction could be achieved by EF, while only about 1.5-14% could be obtained by gravity thickening for the same period. After thickening the effluent water quality in terms of TCOD, SS, and turbidity was improved by EF operation for

Water Science and TechnologyEnvironmental Science
12
Article|10 citations·2022
Prospective sequential comparison of femoral roll-back between cruciate-retaining and posterior-stabilized total knee arthroplasty using an intra-operative sensor
Jae Hyun Kim, Jai Hyung Park, Jun Hyoung Park, Dong-Wook Son, Ji Hyun Ahn
SJR Q2The Knee
SurgeryMedicine
13
Article|8 citations·2014
In vitroSynergism between Chloroquine and Antibiotics againstOrientia tsutsugamushi
Dong-Wook Son, Moon‐Hyun Chung
SJR Q2Infection and ChemotherapyOA

BACKGROUND: To investigate whether chloroquine enhances the effect of antibiotics against Orientia tsutsugamushi, the causative organism of scrub typhus, we compared the effect of antibiotics in combination with chloroquine with the effect of antibiotics alone in vitro. MATERIALS AND METHODS: The Boryong or AFSC-4 strain was inoculated into ECV304 cells, and incubated in medium containing doxycycline (4 µg/mL), rifampin (4 µg/mL), azithromycin (0.5 µg/mL), chloroquine (1 µg/mL), and each of thes

ParasitologyImmunology and Microbiology
14
Article|8 citations·2007
Neuroprotective Effect of Scopoletin from Angelica dahurica on Oxygen and Glucose Deprivation-exposed Rat Organotypic Hippocampal Slice Culture
Dong-Wook Son, Pyeongjae Lee, Jong Seok Lee, Sanghyun Lee, Sang Yoon Choi, Jong-Won Lee, Sun Yeou Kim
SJR Q2Food Science and Biotechnology
Complementary and alternative medicineMedicine
15
Article|7 citations·2008
Severe Paradoxical Reaction Requiring Tracheostomy in a Human Immunodeficiency Virus (HIV)-negative Patient with Cervical Lymph Node Tuberculosis
In-Suh Park, Dong-Wook Son, Chanwoo Lee, Jae Eun Park, Jin Soo Lee, Moon-Hyun Cheong, Young Mo Kim
SJR Q2Yonsei Medical JournalOA

During drug treatment of tuberculous lymphadenitis, paradoxical response (PR) may occasionally occur. Continued treatment or lymph node aspiration improves PR without severe sequelae. However, we report a case of severe PR in a patient with cervical lymph node tuberculosis causing airway obstruction due to retropharyngeal lymph node swelling during antituberculous treatment. Tracheostomy and drainage of the node were performed to secure the airway. Possible airway obstruction due to PR must be s

SurgeryMedicine

Research Areas

SurgeryMolecular BiologyPharmacologyGeriatrics and GerontologyComplementary and alternative medicineParasitology

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