Duksoo Bae
Sungkyunkwan University · 医学
研究室紹介
Professor Duksoo Bae's research lab focuses on molecular oncology and cancer immunology, with a primary emphasis on identifying key molecular mechanisms underlying cervical and ovarian carcinomas. The lab investigates tumor suppressor genes such as BRD7 and signaling molecules like TLR9, ICAM-3, and sphingosine kinase 1 (SK1) to understand their roles in cancer progression, therapy resistance, and immune modulation. Using in vitro, in vivo, and clinical tissue-based approaches, the lab aims to discover novel biomarkers and therapeutic targets for gynecological cancers.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns (PAMPs) and enable innate immune responses. Although TLR9 has been previously considered to be expressed only in immune cells, there is now increasing evidence that TLR9 expression is present in nonimmune cells as well. In this study, we undertook to determine whether TLR9 expression was associated with disease progression in cervical neoplasia. TLR9 expression was evaluated by immunohistochemistry in 55 formalin-fixed p
The RT and RH groups, unlike the CC group, had compromised sexual function after the treatment of early-stage cervical cancer.
PURPOSE: Bromodomain-containing protein 7 (BRD7), which is a subunit of SWI/SNF complex, has been recently suggested as a novel tumor suppressor in several cancers. In this study, we investigated the tumor suppressive effect of BRD7 in epithelial ovarian cancer. EXPERIMENTAL DESIGN: We analyzed the expression of BRD7 in human ovarian tissues with real-time PCR. To investigate the functional role of BRD7, we transfected ovarian cancer cells (A2780 and SKOV3) with BRD7 plasmid and checked the cell