Eunseon Park

Non-alcoholic fatty liver disease (NAFLD) is a global clinical problem. The MD2-TLR4 pathway exacerbates NAFLD progression by promoting inflammation. Long-term exercise is considered to improve NAFLD but the underlying mechanism is still unclear. In this study, we examined the protective effect and molecular mechanism of exercise on high-fat diet (HFD)-induced liver injury. In an HFD-induced NAFLD mouse model, exercise training significantly decreased hepatic steatosis and fibrosis. Interestingl

Src family kinases (SFKs) have been implicated in the pathogenesis of kidney fibrosis. However, the specific mechanism by which SFKs contribute to the progression of diabetic kidney disease (DKD) remains unclear. Our preliminary transcriptome analysis suggested that SFK expression was increased in diabetic kidneys and that the expression of Fyn (a member of the SFKs), along with genes related to unfolded protein responses from the endoplasmic reticulum (ER) stress signaling pathway, was upregula

본 연구는 삶의 의미와 정신건강과의 관계를 파악하기 위해 1997년부터 2013년까지 국내의 연구논문 총 38편에 대해 메타분석을 실시하였다(N=13,961). 정신건강은 Hackney와 Sanders (2003)의 기준에 따라 우울과 불안의 부정적 지표와 주관적 안녕감과 심리적 안녕감의 긍정적 지표로 분류하였다. 그 결과 삶의 의미와 정신건강의 부정적 지표간의 평균 효과크기(r)는 -.152로 통계적으로 유의미하지 않았던 반면, 삶의 의미와 정신건강의 긍정적 지표간의 평균 효과크기(r)는 0.499로 통계적으로 유의미하였다. 삶의 의미와 정신건강의 긍정적 지표간의 평균 효과크기는 큰 효과크기로 삶의 의미가 높을수록 주관적 안녕감과 심리적 안녕감이 높아지는 관계를 보였다. 이에 대한 하위집단 분석결과 삶의 의미와 정신건강 긍정적 지표의 측정영역에 따라 차이가 나타났는데 주관적 안녕감보다 심리적 안녕감과의 관계가 더 큰 것으로 나타났다. 또한 연구대상 연령에 따른 집단차이를 보였는데,

Acute kidney injury (AKI), a critical syndrome characterized by a rapid decrease of kidney function, is a global health problem. Src family kinases (SFK) are proto-oncogenes that regulate diverse biological functions including mitochondrial function. Since mitochondrial dysfunction plays an important role in the development of AKI, and since unbalanced SFK activity causes mitochondrial dysfunction, the present study examined the role of SFK in AKI. Lipopolysaccharides (LPS) inhibited mitochondri

Acute kidney injury (AKI), which is defined as a rapid decline of renal function, becomes common and recently recognized to be closely intertwined with chronic kidney diseases. Current treatment for AKI is largely supportive, and endoplasmic reticulum (ER) stress has emerged as a novel mediator of AKI. Since carbon monoxide attenuates ER stress, the objective of the present study aimed to determine the protective effect of carbon monoxide releasing molecule-2 (CORM2) on AKI associated with ER st

Acute kidney injury (AKI) is a common disease with a complex pathophysiology which significantly contributes to the development of chronic kidney disease and end stage kidney failure. Preventing AKI can consequently reduce mortality, morbidity, and healthcare burden. However, there are no effective drugs in use for either prevention or treatment of AKI. Developing therapeutic agents with pleiotropic effects covering multiple pathophysiological pathways are likely to be more effective in attenuat

삶의 의미는 사회적 관심과 더불어 최근 심리학 분야에서 활발히 연구되고 있는 주제이나 이에 대한 이론적 정립이나 경험연구는 충분히 이루어지지 않은 실정이다. 이에 본 연구는 삶의 의미 연구의 동향을 파악하고 이에 따른 향후 과제를 논하고자 1997년부터 2012년까지 최근 16년 동안에 발표된 국내 석․박사 학위논문과 학술지 논문 총 195편을 내용분석하였다. 그 결과 논문 수는 2000년대 이후, 특히 2007년 이후에 크게 증가했으며 이 중 성인기를 대상으로 한 연구가 가장 많았다. 주제면에서는 삶의 질, 자존감 등 개인적 차원의 변인들과의 관계를 주로 연구하였는데 이를 임상군과 고위험군, 비임상군 등으로 나누어 보았을 때는 큰 차이를 보이지 않았다. 삶의 의미 측정도구로는 PIL을 가장 많이 사용했으나 최근 MLQ의 사용이 증가하는 추세에 있으며 국내에서 개발된 척도들도 보고되었다. 질적연구에 비해 양적 연구가, 그리고 이론적인 연구에 비해 경험연구가 훨씬 많았으며 회귀분석을

Acute kidney injury (AKI) most commonly appears in critically ill patients in hospitals. AKI is characterized as a quick deterioration of kidney function and has recently been identified to be tightly interlinked with chronic kidney diseases. The emerging major mediators of AKI include oxidative stress and endoplasmic reticulum (ER) stress. Carbon monoxide (CO) attenuates oxidative stress and ER stress in various cells, while Fyn, a member of the Src kinase family, is activated by oxidative stre

Diabetic kidney disease (DKD) is now a pandemic worldwide, and novel therapeutic options are urgently required. Adenosine, an adenosine triphosphate metabolite, plays a role in kidney homeostasis through interacting with four types of adenosine receptors (ARs): A1AR, A2AAR, A2BAR, and A3AR. Increasing evidence highlights the role of adenosine and ARs in the development and progression of DKD: 1) increased adenosine in the plasma and urine of diabetics with kidney injury, 2) increased expression

Kidney fibrosis is the final outcome of chronic kidney disease (CKD). Adenosine plays a significant role in protection against cellular damage by activating four subtypes of adenosine receptors (ARs), A1AR, A2AAR, A2BAR, and A3AR. A2AAR agonists protect against inflammation, and A3AR antagonists effectively inhibit the formation of fibrosis. Here, we showed for the first time that LJ-4459, a newly synthesized dual-acting ligand that is an A2AAR agonist and an A3AR antagonist, prevents the progre

This study aims to explore the possibility of using Twitter in Korean education and to describe the educational effect of Twitter on Korean education. To accomplish this job I have investigated how students use Twitter for learning Korean, their perception on Twitter and whether incidental vocabulary learning has occurred after using it. 15 students who registered for intermediate Korean lesson participated in this study. After performing tasks using Twitter, a questionnaire and oral interview w

Abstract Lipid metabolism, particularly fatty acid oxidation dysfunction, is a major driver of renal fibrosis. However, the detailed regulatory mechanisms underlying this process remain unclear. Here we demonstrated that acyl-CoA thioesterase 12 (Acot12), an enzyme involved in the hydrolysis of acyl-CoA thioesters into free fatty acids and CoA, is a key regulator of lipid metabolism in fibrotic kidneys. A significantly decreased level of ACOT12 was observed in kidney samples from human patients

ABSTRACT Triple‐negative breast cancer (TNBC) remains a challenge due to its aggressive nature and limited therapeutic options. Calpain 2, a member of the calcium‐dependent cysteine protease family, is particularly associated with poor prognosis in TNBC. This study explores the isoform‐specific role of calpain 2 in TNBC, examining its correlation with prognosis and its mechanistic impact on metastasis. Bioinformatic analyses, including Kaplan–Meier survival plots, univariate Cox proportional ana