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Gwang-hyun Kim

Ewha Womans University · 医学

研究室紹介

Professor Gwang-hyun Kim's research lab specializes in urological oncology and minimally invasive surgical techniques, with a strong focus on improving diagnostic accuracy and treatment outcomes in genitourinary cancers. The lab investigates liquid biopsy applications using cell-free and exosomal DNA from urine for non-invasive detection of urothelial bladder carcinoma, and explores prognostic factors in renal cell carcinoma, particularly the impact of histological subtypes on survival. Additionally, the lab contributes to advancing robotic and single-port surgical approaches for prostate and bladder cancer, emphasizing perioperative outcomes and complications such as post-cystectomy urinary tract infections. Their work bridges molecular diagnostics, surgical innovation, and clinical oncology to enhance personalized patient care.

urothelial carcinomaliquid biopsyrobotic surgeryrenal cell carcinomaurinary tract infection

Research Overview

Papers
209
Total Citations
2,605
Papers (5y)
35
Primary Field
医学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
35total
2022
2023
2024
2025
2026
Citations per year (5y)
187total
20222023202420252026

Selected Papers

15
1
Article|131 citations·2000
Pyriform Sinus Fistula: Management with Chemocauterization of the Internal Opening
Kwang Hyun Kim, Myung‐Whun Sung, Seung Ha Oh, Tae‐Yong Koh, In-Sang Kim
SJR Q2Annals of Otology Rhinology & Laryngology

A branchial remnant originating in the pyriform sinus causes a recurrent fistula or abscess in the neck. In spite of excision, recurrence may result from inadequate removal of the fistula tract. We attempted chemocauterization of the internal opening of the fistula tract with trichloroacetic acid (TCA) on direct endoscopy. This is a 6-year review of 18 patients with pyriform sinus fistula. Medical history, barium esophagography, computed tomography scans, operative findings, and treatment result

SurgeryMedicine
2
Article|65 citations·2018
Urinary Exosomal and cell-free DNA Detects Somatic Mutation and Copy Number Alteration in Urothelial Carcinoma of Bladder
Dong Hyeon Lee, Hana Yoon, Sanghui Park, Jeong Seon Kim, Young‐Ho Ahn, Kihwan Kwon, Donghwan Lee, Kwang Hyun Kim
SJR Q1Scientific ReportsOA

Urothelial bladder carcinoma (UBC) is characterized by a large number of genetic alterations. DNA from urine is a promising source for liquid biopsy in urological malignancies. We aimed to assess the availability of cell-free DNA (cfDNA) and exosomal DNA (exoDNA) in urine as a source for liquid biopsy in UBC. We included 9 patients who underwent surgery for UBC and performed genomic profiling of tumor samples and matched urinary cfDNA and exoDNA. For mutation analysis, deep sequencing was perfor

SurgeryMedicine
3
Article|58 citations·2013
Extended vs standard lymph node dissection in robot‐assisted radical prostatectomy for intermediate‐ or high‐risk prostate cancer: a propensity‐score‐matching analysis
Kwang Hyun Kim, Sey Kiat Lim, Ha Yan Kim, Tae Young Shin, Joo Yong Lee, Young Deuk Choi, Byung Ha Chung, Sung Joon Hong, Koon Ho Rha
SJR Q1British Journal of UrologyOA

UNLABELLED: WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Although lymph node dissection (LND) is known as the most accurate method of nodal staging, the therapeutic role of LND remains undetermined. This is mainly because of the lack of randomized prospective studies and the fact that retrospective analyses often result in bias and misinterpretation. To overcome the limitation of retrospective analysis, we matched preoperative variables using propensity scores and compared the outc

Pulmonary and Respiratory MedicineMedicine
4
Article|36 citations·2012
Type II papillary histology predicts poor outcome in patients with renal cell carcinoma and vena cava thrombus
Kwang Hyun Kim, Dalsan You, In Gab Jeong, Tae‐Won Kwon, Yong Mee Cho, Jun Hyuk Hong, Hanjong Ahn, Choung‐Soo Kim
SJR Q1British Journal of Urology

UNLABELLED: What's known on the subject? and What does the study add? In patients with pRCC, the presence of venous tumour thrombus is known to be a predictor of poorer outcomes. However, a paucity of data is available regarding the prognostic significance of histology in patients with RCC and IVC thrombus. In our series, we found that patients with type II pRCC had significantly poorer outcomes when compared to those with cRCC. Although the lack of effective treatment for patients with metastat

Pulmonary and Respiratory MedicineMedicine
5
Article|33 citations·2012
Muscle-invasive bladder cancer developing after nephroureterectomy for upper urinary tract urothelial carcinoma
Kwang Hyun Kim, Dalsan You, In Gab Jeong, Jun Hyuk Hong, Hanjong Ahn, Choung‐Soo Kim
SJR Q1Urologic Oncology Seminars and Original Investigations
SurgeryMedicine
6
Article|32 citations·2020
Single-port robot-assisted radical prostatectomy with the da Vinci SP system: A single surgeon's experience
Kwang Hyun Kim, Wan Song, Hana Yoon, Dong Hyeon Lee
SJR Q1Investigative and Clinical UrologyOA

Purpose: To report an initial single-surgeon experience with single-port robot-assisted radical prostatectomy (SP-RARP) using the da Vinci SP surgical system (Intuitive Surgical, USA). Materials and Methods: Between December 2018 and October 2019, a single surgeon performed SP-RARP in 20 patients with prostate cancer. SP-RARP was performed using the conventional approach through an umbilical port with a GelPOINT access system (Applied Medical, USA) and an additional assist port. During surgery,

SurgeryMedicine
7
Article|30 citations·2013
Upgrading of G leason score and prostate volume: a clinicopathological analysis
Kwang Hyun Kim, Sey Kiat Lim, Tae Young Shin, Joo Yong Lee, Byung Ha Chung, Koon Ho Rha, Sung Joon Hong
SJR Q1British Journal of UrologyOA

OBJECTIVE: To more clearly elucidate the association between prostate volume and Gleason score (GS) upgrading. PATIENT AND METHODS: We reviewed 451 patients with prostate cancer with a GS of 6 on biopsy, who underwent radical prostatectomy without neoadjuvant treatment. As a preoperative variable, we assessed the independent effect of prostate volume on GS upgrading. To evaluate the association between prostate volume and GS upgrading, we developed multivariate models with volumetric pathologica

Pulmonary and Respiratory MedicineMedicine
8
Article|30 citations·2016
Febrile Urinary Tract Infection after Radical Cystectomy and Ileal Neobladder in Patients with Bladder Cancer
Kwang Hyun Kim, Hyun Suk Yoon, Hana Yoon, Woo Sik Chung, Bong Suk Sim, Dong Hyeon Lee
SJR Q2Journal of Korean Medical ScienceOA

Urinary tract infection (UTI) is one of the most common complications after radical cystectomy and orthotopic neobladder reconstruction. This study investigated the incidence and implicated pathogen of febrile UTI after ileal neobladder reconstruction and identify clinical and urodynamic parameters associated with febrile UTI. From January 2001 to May 2015, 236 patients who underwent radical cystectomy and ileal neobladder were included in this study. Fifty-five episodes of febrile UTI were iden

SurgeryMedicine
9
Article|28 citations·2011
Incidentally Detected Inguinoscrotal Bladder Hernia
Kwang Hyun Kim, Myung Up Kim, Woo‐Jin Jeong, Yong Seung Lee, Ki Hong Kim, Kyung Kgi Park, Mun Su Chung, Byung Ha Chung, Seung Hwan Lee
Korean journal of urologyOA

The bladder is involved in less than 4% of inguinal hernias. Inguinoscrotal bladder hernias are difficult to diagnose, and less than 7% are diagnosed preoperatively. Inguinoscrotal bladder hernias are usually asymptomatic. However, they can result in significant complications, such as bladder necrosis or acute renal failure. Accurate diagnosis is crucial to avoid bladder injury during surgery and other complications. Here we report the case of a 64-year-old man who presented with a scrotal mass.

SurgeryMedicine
10
Article|28 citations·2020
Comparison of Four Commercial Kits for Isolation of Urinary Cell-Free DNA and Sample Storage Conditions
Eun Young Lee, Eun‐Ju Lee, Hana Yoon, Dong Hyeon Lee, Kwang Hyun Kim
SJR Q2DiagnosticsOA

Urinary cell-free DNA (cfDNA) is an attractive body fluid for liquid biopsy. In this study, we compared the efficiencies of four commercial kits for urinary cell-free DNA (cfDNA) isolation and of various sample storage conditions. Urinary cfDNA was isolated from 10 healthy individuals using four commercial kits: QIAamp Circulating Nucleic Acid Kit (QC; Qiagen), MagMAX™ Cell-Free DNA Isolation Kit (MM; Applied Biosystems), Urine Cell-Free Circulating DNA Purification Midi Kit (NU; Norgen Biotek),

Cancer ResearchBiochemistry, Genetics and Molecular Biology
11
Article|26 citations·2022
Technique and perioperative outcomes of single-port robotic surgery using the da Vinci SP platform in urology
Kwang Hyun Kim, Hyun Kyu Ahn, Myong Kim, Hana Yoon
SJR Q2Asian Journal of SurgeryOA

The da Vinci SP system provides a new robotic surgical platform for single port surgery while maintaining the major features of robotic surgery similar to multi-port surgery. Various single port urologic surgeries can be safely performed with this platform.

SurgeryMedicine
12
Article|24 citations·2016
Risk Factors for Developing Metabolic Acidosis after Radical Cystectomy and Ileal Neobladder
Kwang Hyun Kim, Hyun Suk Yoon, Hana Yoon, Woo Sik Chung, Bong Suk Sim, Dong‐Ryeol Ryu, Dong Hyeon Lee
SJR Q1PLoS ONEOA

Approximately, half of patients experienced metabolic acidosis one month after ileal neobladder reconstruction. Preoperative impaired renal function was the most significant risk factor for developing metabolic acidosis in the early postoperative period. However, the incidence of metabolic acidosis decreased to less than 20% 1 year after surgery, and diabetes was an independent risk factor during this period.

SurgeryMedicine
13
Article|20 citations·2013
Tumor Volume Adds Prognostic Value in Patients with Organ-Confined Prostate Cancer
Kwang Hyun Kim, Sey Kiat Lim, Tae Young Shin, Dae Ryong Kang, Woong Kyu Han, Byung Ha Chung, Koon Ho Rha, Sung Joon Hong
SJR Q1Annals of Surgical OncologyOA
Pulmonary and Respiratory MedicineMedicine
14
Article|19 citations·2016
Febrile Urinary Tract Infection after Radical Cystectomy and Ileal Neobladder in Patients with Bladder Cancer
김광현, 윤현석, 윤하나, 정우식, 심봉석, 이동현
Journal of Korean Medical Science

Urinary tract infection (UTI) is one of the most common complications after radical cystectomy and orthotopic neobladder reconstruction. This study investigated the incidence and implicated pathogen of febrile UTI after ileal neobladder reconstruction and identify clinical and urodynamic parameters associated with febrile UTI. From January 2001 to May 2015, 236 patients who underwent radical cystectomy and ileal neobladder were included in this study. Fifty-five episodes of febrile UTI were iden

15
Article|18 citations·2017
Clinical validation of serum endocan (ESM-1) as a potential biomarker in patients with renal cell carcinoma
Kwang Hyun Kim, Hyung Ho Lee, Young Eun Yoon, Joon Chae Na, Sook Young Kim, Young In Cho, Sung Joon Hong, Woong Kyu Han
SJR Q2OncotargetOA

To determine the suitability of serum endocan (ESM-1) levels for diagnosing and monitoring renal cell carcinoma (RCC), we measure serum ESM-1 levels in 56 RCC patients who had undergone radical or partial nephrectomies and 56 age- and sex-matched healthy kidney donors. Measurements were made before and 1 month and 3 months after surgery. The areas under the curve (AUCs) were determined from receiver operating characteristic (ROC) analyses. RCC patients had higher mean serum ESM-1 levels than con

ImmunologyImmunology and Microbiology

Research Areas

Pulmonary and Respiratory MedicineSurgeryEpidemiologyMaterials ChemistryPublic Health, Environmental and Occupational HealthImmunology

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