Gyeong Hoon Kang
Seoul National University · 医学
研究室紹介
Professor Gyeong Hoon Kang's research lab specializes in molecular oncology, with a primary focus on epigenetic alterations in carcinogenesis. The lab investigates DNA methylation patterns—particularly CpG island hypermethylation and global hypomethylation—in various gastrointestinal and genitourinary cancers, including gastric, colorectal, and prostate cancers. Key research directions include identifying methylation biomarkers for early detection, understanding the CpG island methylator phenotype (CIMP), and exploring the interplay between epigenetic changes and immune microenvironments, such as PD-L1 expression in MSI-high colorectal cancers. The lab also develops immunohistochemical panels to improve the diagnosis of metastatic adenocarcinoma by determining the primary site of origin.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15There are limited reports on methylation analysis of the premalignant lesions of gastric carcinoma thus far. This is despite the fact that gastric carcinoma is one of the tumors with a high frequency of CpG island hypermethylation. To determine the frequency and timing of hypermethylation during multistep gastric carcinogenesis, non-neoplastic gastric mucosa (n = 118), adenomas (n = 61), and carcinomas (n = 64) were analyzed for their p16, human Mut L homologue 1 (hMLH1), death-associated protei
To date, several reports have been published about CpG island methylation of various genes in prostate cancer. However, most of these studies have focused on cancer tissue only or a single gene and data about concurrent methylation of multiple genes in prostate cancer or prostatic intraepithelial neoplasia (PIN) are limited. The aim of the present study was to determine the methylation profile of 11 tumour-related genes in prostate cancer and PIN. Seventy-one samples, including 37 prostate cance
Abstract Context.—Although identification of the primary tumor in patients with metastatic adenocarcinoma has a profound clinical impact, diagnosing the organ of origin is frequently difficult. Because none of the individual immunohistochemical markers used for tissue identification are both site specific and site sensitive, multiple markers are needed to improve the prediction of primary sites. Objective.—To develop an effective approach to immunohistochemically evaluate metastatic adenocarcino
Promoter CpG island hypermethylation is an important carcinogenic event in prostate adenocarcinoma. Regardless of tissue type, human cancers have in common both focal CpG island hypermethylation and global genomic hypomethylation. The present study evaluated CpG island loci hypermethylation and LINE-1 and Alu repeat hypomethylation in prostate adenocarcinoma, analysed the relationship between them, and correlated these findings with clinicopathological features. We examined 179 cases of prostate
CpG island methylator phenotype (CIMP) is a recently described subset of colorectal cancers (CRC) with widespread methylation of multiple promoter CpG islands. But the prognostic implication of CIMP in CRC has not been clarified. Thus, the aim of the present study was to differentiate the unique characteristics of CIMP from those of microsatellite instability (MSI)-high CRC, especially with regard to prognosis. CIMP, MSI, and mutations of KRAS codons 12 and 13 and of BRAF codon 600 were evaluate
Research Areas
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