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Haijeon Yoon

Ewha Womans University · 医学

研究室紹介

Professor Haijeon Yoon's research lab specializes in nuclear medicine and molecular imaging, with a focus on improving cancer prognosis and treatment response prediction through advanced medical imaging techniques. The lab investigates tumor heterogeneity using textural analysis of FDG-PET and diffusion-weighted MRI in breast and gastric cancers, explores the clinical implications of physiological FDG uptake in the gut related to microbiota and inflammation, and evaluates lymphoscintigraphy and SPECT/CT for lymphedema staging and surgical outcome prediction. Their work bridges medical imaging, oncology, and molecular biology to enhance personalized cancer care and lymphatic system diagnostics.

molecular imagingcancer prognosislymphoscintigraphyFDG-PETtumor heterogeneity

Research Overview

Papers
86
Total Citations
958
Papers (5y)
33
Primary Field
医学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
33total
2022
2023
2024
2025
2026
Citations per year (5y)
134total
20222023202420252026

Selected Papers

15
1
Article|84 citations·2014
Correlation of breast cancer subtypes, based on estrogen receptor, progesterone receptor, and HER2, with functional imaging parameters from 68Ga-RGD PET/CT and 18F-FDG PET/CT
Hai‐Jeon Yoon, Keon Wook Kang, In Kook Chun, Nariya Cho, Seock‐Ah Im, Sunjoo Jeong, Song Lee, Kyeong Cheon Jung, Yun‐Sang Lee, Jae Min Jeong, Dong Soo Lee, June-Key Chung
SJR Q1European Journal of Nuclear Medicine and Molecular Imaging
Radiology, Nuclear Medicine and ImagingMedicine
2
Article|73 citations·2015
Intratumoral metabolic heterogeneity predicts invasive components in breast ductal carcinoma in situ
Hai‐Jeon Yoon, Yemi Kim, Bom Sahn Kim
SJR Q1European Radiology
Radiology, Nuclear Medicine and ImagingMedicine
3
Article|60 citations·2018
Predicting neo‐adjuvant chemotherapy response and progression‐free survival of locally advanced breast cancer using textural features of intratumoral heterogeneity on F‐18 FDG PET / CT and diffusion‐weighted MR imaging
Hai‐Jeon Yoon, Yemi Kim, Jin Chung, Bom Sahn Kim
SJR Q2The Breast Journal

Predicting response to neo-adjuvant chemotherapy (NAC) and survival in locally advanced breast cancer (LABC) is important. This study investigated the prognostic value of tumor heterogeneity evaluated with textural analysis through F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) and diffusion-weighted imaging (DWI). We enrolled 83 patients with LABC who had completed NAC and curative surgery. Tumor texture indices from pretreatment FDG PET and DWI were extracted from histogram a

Radiology, Nuclear Medicine and ImagingMedicine
4
Article|26 citations·2018
Prognostic value of diffuse splenic FDG uptake on PET/CT in patients with gastric cancer
Hai‐Jeon Yoon, Bom Sahn Kim, Chang Mo Moon, Jang Yoo, Ko Eun Lee, Yemi Kim
SJR Q1PLoS ONEOA

Diffuse splenic uptake on FDG PET/CT was correlated with the level of hematological and inflammatory parameters and was an independent predictor for RFS in GC.

OncologyMedicine
5
Article|24 citations·2012
New Application of Dual Point 18F-FDG PET/CT in the Evaluation of Neoadjuvant Chemoradiation Response of Locally Advanced Rectal Cancer
Hai‐Jeon Yoon, Seok-Ki Kim, Tae Sung Kim, Hyung‐Jun Im, Eun Seong Lee, Hyun Chul Kim, Ji Won Park, Hee Jin Chang, Hyo Seong Choi, Dae Yong Kim, Jae Hwan Oh
SJR Q2Clinical Nuclear Medicine

Dual-point post-CRT PET/CT can predict pathological tumor response better than conventional single time point pre- and post-CRT PET/CT.

OncologyMedicine
6
Article|22 citations·2019
Physiologic intestinal 18F-FDG uptake is associated with alteration of gut microbiota and proinflammatory cytokine levels in breast cancer
Hai‐Jeon Yoon, Han‐Na Kim, Ji-In Bang, Woosung Lim, Byung-In Moon, Nam Sun Paik, Bom Sahn Kim, Hyung‐Lae Kim
SJR Q1Scientific ReportsOA

Abstract The clinical significance of physiologic Fluorine-18-fluorodeoxyglucose ( 18 F-FDG) intestinal uptake (IU) based on the predicted link with gut microbiota dysbiosis and inflammatory cytokine production was investigated in a cohort of breast cancer patients. A total of 114 patients were visually classified into the lower or higher IU group. The maximum and mean standardized uptake values of total bowel (TB SUV max and TB SUV mean ) were measured. The gut microbial abundance of the Citrob

Molecular BiologyBiochemistry, Genetics and Molecular Biology
7
Article|19 citations·2021
Lymphoscintigraphic Findings as Indicators of Lymphaticovenous Anastomosis Outcome in Patients With Extremity Lymphedema
Hye Ok Kim, Kyong-Je Woo, Bom Sahn Kim, Seo Young Kang, Byung Seok Moon, Hai‐Jeon Yoon
SJR Q2Clinical Nuclear Medicine

PURPOSE: This study was performed to evaluate the usefulness of lymphoscintigraphy in predicting the surgical outcomes of lymphaticovenous anastomosis (LVA) in a patient with extremity lymphedema. PATIENTS AND METHODS: We retrospectively evaluated 133 patients with extremity lymphedema who underwent lymphoscintigraphy followed by LVA surgery from February 2018 to March 2020. Lymphoscintigraphic findings were evaluated on the following parameters: the extent of dermal backflow (small/large), lymp

OncologyMedicine
8
Article|18 citations·2023
The added value of SPECT/CT lymphoscintigraphy in the initial assessment of secondary extremity lymphedema patients
Hai‐Jeon Yoon, Kyong-Je Woo, Jiyoung Kim, Seo Young Kang, Byung Seok Moon, Bom Sahn Kim
SJR Q1Scientific ReportsOA

An added value of SPECT/CT over planar lymphoscintigraphy for initial staging in patients with secondary extremity lymphedema was investigated. Furthermore, we developed a hybrid SPECT/CT classification combining dermal backflow (DBF) of SPECT and honeycomb pattern (HP) of CT, correlated it with lymphoscintigraphic staging and clinical severity. Forty-one patients with secondary extremity lymphedema who underwent lymphoscintigraphy with SPECT/CT were included retrospectively. The severity of ext

OncologyMedicine
9
Article|17 citations·2014
Background 99mTc-methoxyisobutylisonitrile uptake of breast-specific gamma imaging in relation to background parenchymal enhancement in magnetic resonance imaging
Hai‐Jeon Yoon, Yemi Kim, Jee Eun Lee, Bom Sahn Kim
SJR Q1European Radiology
Radiology, Nuclear Medicine and ImagingMedicine
10
Article|17 citations·2021
Asymmetric Amyloid Deposition as an Early Sign of Progression in Mild Cognitive Impairment Due to Alzheimer Disease
Hai‐Jeon Yoon, Bom Sahn Kim, Jee Hyang Jeong, Geon Ha Kim, Hee Kyung Park, Min Young Chun
SJR Q2Clinical Nuclear Medicine

PURPOSE: In typical Alzheimer disease with dementia (ADD), amyloid pathologies affect both cerebral hemispheres symmetrically. However, the spatial distribution of amyloid-β (Aβ) in the early stage of ADD or over the course of disease has not been investigated. Therefore, we explored asymmetric pattern of Aβ deposition in both hemispheres according to the ADD continuum using 18F-florbetaben PET. METHODS: Sixty-eight subjects, including 15 Aβ-negative normal controls, 28 Aβ-positive mild cognitiv

PhysiologyMedicine
11
Article|16 citations·2013
Regional PET/CT after water gastric inflation for evaluating loco-regional disease of gastric cancer
Soo Jin Lee, Won Woo Lee, Hai‐Jeon Yoon, Ho‐Young Lee, Kyoung Ho Lee, Young Hoon Kim, Do Joong Park, Hyung‐Ho Kim, Young So, Sang Eun Kim
SJR Q1European Journal of Radiology
Pulmonary and Respiratory MedicineMedicine
12
Article|15 citations·2024
Alterations in Gut Microbiota and Their Correlation with Brain Beta-Amyloid Burden Measured by 18F-Florbetaben PET in Mild Cognitive Impairment Due to Alzheimer’s Disease
Geon Ha Kim, Bori R. Kim, Hai‐Jeon Yoon, Jee Hyang Jeong
SJR Q1Journal of Clinical MedicineOA

(1) Background: This study investigated changes in the gut microbial composition of individuals with mild cognitive impairment (MCI) due to Alzheimer’s disease (AD) and their relationship with positron emission tomography (PET) amyloid accumulation. (2) Methods: In total, 17 cognitively normal individuals without amyloid-beta (Aβ) accumulation (Aβ−NC) and 24 with Aβ-positive mild cognitive impairment (Aβ+MCI) who underwent 18F-florbetaben PET and fecal bacterial 16S ribosomal RNA gene sequencing

Molecular BiologyBiochemistry, Genetics and Molecular Biology
13
Article|13 citations·2019
Prognostic value of 18F-FDG brain PET as an early indicator of neurological outcomes in a rat model of post-cardiac arrest syndrome
Daehee Kim, Hai‐Jeon Yoon, Woon Jeong Lee, Seon Hee Woo, Bom Sahn Kim
SJR Q1Scientific ReportsOA

Abstract Predicting neurological outcomes in patients with post-cardiac arrest syndrome (PCAS) is crucial for identifying those who will benefit from intensive care. We evaluated the predictive value of 18F-FDG PET. PCAS was induced in Sprague Dawley rats. Baseline and post-3-hour images were acquired. Standardized uptake value (SUV) changes before and after PCAS induction (SUV delta ) and SUV ratios (SUVR) of regional SUV normalized to the whole brain SUV were obtained. The Morris water maze (M

Emergency MedicineMedicine
14
Review|12 citations·2019
Changes in medical research trends of North Korea after economic sanctions
Hai‐Jeon Yoon, Seon Hee Woo, Daehee Kim, Ju Hyun Um, Sae Hyun Park, Ah Ram Seo
SJR Q3MedicineOA

BACKGROUND: In the 1980s, North Korea established a socialist health care system. However, following the food crisis and the economic sanctions, it is estimated that North Korea's health care system has experienced continuous deterioration. Thus, in the present study, we estimated the current medical research trends of North Korea through an analysis of the medical journal Korean Medicine, published in North Korea. METHODS: We analyzed the studies in Korean Medicine, which is the only North Kore

Sociology and Political ScienceSocial Sciences
15
Article|12 citations·2015
Prognostic value of semi-quantitative tumor uptake on Tc-99m sestamibi breast-specific gamma imaging in invasive ductal breast cancer
Hai‐Jeon Yoon, Yemi Kim, Kyu-Tae Chang, Bom Sahn Kim
SJR Q2Annals of Nuclear Medicine
Cancer ResearchBiochemistry, Genetics and Molecular Biology

Research Areas

Radiology, Nuclear Medicine and ImagingOncologyMolecular BiologyNeurologyPulmonary and Respiratory MedicineEmergency Medicine

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