Hak Chang

Background The study objective was to examine the correlation between regional ventilation distribution measured with electrical impedance tomography ( EIT ) and weaning outcomes during spontaneous breathing trial ( SBT ). Methods Fifteen patients received 100% automatic tube compensation ( ATC ) during the first and 70% during the second hour. Another 15 patients received external continuous positive airway pressure ( CPAP ) of 5 and 7.5 cmH 2 O during the first and second hours, respectively.

A significant clinical problem in reconstructive surgery is partial loss of a pedicled flap. To resolve this problem, various methods of vascular augmentation have been developed; "supercharging" is one of those techniques. A new rat flap model was developed for investigation of the supercharging procedure, and the efficacy of the arterial supercharging method was examined. The purpose of this study was to investigate how an arterial supercharging procedure could generate large flap survival are

BACKGROUND: Acral melanoma (AM) is the most common histopathological subtype of malignant melanoma in Asians. However, differences in the mutational profiles underlying AM and nonacral cutaneous melanoma (NAM) in Asians are not well understood. OBJECTIVES: To augment the understanding of the prevalence, patterns and associations of various mutations between different subtypes of melanoma. METHODS: We performed comprehensive genomic profiling of 409 cancer-associated genes, using next-generation

This study demonstrates that venous augmentation is also effective for increasing flap survival, and the distal procedure is more effective than the proximal procedure in arterial supercharging.

BACKGROUND: Pharmacologic augmentation to mimic the delay phenomenon that increases skin flap survival has been studied extensively. Tadalafil is a phosphodiesterase V inhibitor that is used for treatment of erectile dysfunction by enhancing vascular smooth muscle relaxation. OBJECTIVE: The aim of this study was to investigate the effects of local injection of tadalafil in enhancing axial-pattern skin flap survival in rats. MATERIALS AND METHODS: Twenty Sprague-Dawley rats were used and a McFarl

The subdermal plexus of the face was angiographically investigated using ten fresh cadavers injected with a radio-opaque lead oxide-gelatin mixture over the entire body. The subdermal vessels were unique in each region of the face, and the author classified the vessels into three kinds according to their running forms, shape of their skin territories, and arrangement of the territories. A kind of line by anastomoses of the subdermal vessels which are mutually adjacent or by the quite elongated s

Although silicone implants are widely used in breast and other reconstructive surgeries, the limited biocompatibility of these materials leads to severe complications, including capsular contracture. Here, we aimed to clarify the relationship between periostin and the process of capsule formation after in vivo implantation. Seven-week-old wild-type (WT) C57BL/6 mice and periostin-deficient mice were used. Round silicone implants were inserted into a subcutaneous pocket on the dorsum of the mice.

Current clinical and anatomical studies show that the venous problem associated with the deep inferior epigastric perforator flap results from poor midline-crossing. We examined the venous anatomy of the infraumbilical midline area and the dynamic venous flow of the deep inferior epigastric perforator flap in nine fresh cadavers. All nine abdominal specimens were harvested between the subcostal margin and the groin crease. Two specimens were used to analyze the abdominal venous anatomy, one of w

BACKGROUND: The viable zone where adipocytes and/or adipose-derived stem cells survive is present at the surface of graft fat tissue; however, there is controversy regarding the zone thickness. Graft retention could be improved if more adipocytes are included in the zone. OBJECTIVES: We hypothesize that a temporary reduction in adipocyte size prior to grafting could increase the number of adipocytes in the viable zone. We reduced the adipocyte size by treatment with MLN4924, which controls lipid

We demonstrated that muscle free flap without reinnervation eventually converts into adipose tissue regardless of spontaneous reinnervation during muscle regeneration. The long-term findings of the present study will be valuable for muscle flap selection and prognosis.