Hang-Nyung Choi
Yonsei University · 医学
研究室紹介
Professor Hang-Nyung Choi's research lab specializes in molecular and translational hepatology, focusing on the genetic and cellular mechanisms underlying liver diseases, particularly progressive familial intrahepatic cholestasis type 3 (PFIC3). The lab investigates the functional impact of ABCB4 gene mutations on multidrug resistance protein 3 (MDR3) trafficking and phosphatidylcholine transport, using in vitro molecular and biochemical assays. Additionally, the lab explores neurobiological underpinnings of behavioral disorders, such as Internet gaming disorder and alcohol use disorder, through neuroimaging techniques to identify structural brain alterations. The overarching goal is to bridge molecular pathology with clinical phenotypes to advance precision diagnostics and therapeutic strategies.
Research Overview
Research Output Trend
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Selected Papers
2Multidrug resistance 3 (MDR3), encoded by the ATP-binding cassette, subfamily B, member 4 gene (ABCB4), localizes to the canalicular membrane of hepatocytes and translocates phosphatidylcholine from the inner leaflet to the outer leaflet of the canalicular membrane. Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a rare hepatic disease caused by genetic mutations of ABCB4. In this study, we characterized 8 ABCB4 mutations found in PFIC3 patients, using in vitro molecular assays.
Objectives ： The purpose of the present study was to conduct a comparison of structural brain alterations between people with Internet gaming disorder (IGD) and alcohol use disorder (AUD) in young males. Methods ： Twenty-four young males with IGD, 22 young males with AUD, and 30 healthy control (HC) subjects participated in this study. We applied voxel-based morphometric analysis with diffeomorphic anatomical registration using an exponentiated Lie algebra algorithm. A whole-brain analysis was c
Research Areas
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