Hanseul Yang
Korea Advanced Institute of Science and Technology · 免疫学・微生物学
研究室紹介
Professor Hanseul Yang's research lab focuses on understanding the molecular and metabolic mechanisms underlying acute inflammatory diseases, particularly acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). The lab employs multi-omics approaches—integrating genomics, metabolomics, and epigenomics—to dissect the role of immune cell crosstalk and metabolite signaling in disease progression. A key discovery in the lab is the identification of neutrophil-derived itaconate as a critical extracellular metabolite that orchestrates immune cell infiltration and epigenetic reprogramming in the lung microenvironment. The lab aims to translate these findings into novel therapeutic strategies targeting metabolic-immune crosstalk in critical inflammatory conditions.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
1Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), present a substantial clinical burden, magnified by conditions such as COVID-19. While these conditions provide a model for exploring complex inflammatory processes, the environmental factors coordinating these responses remain poorly understood. Here, we employ comprehensive multi-omics and biochemical analyses and identify neutrophil-derived itaconate as an extracellular factor associated with sequential i