Hu-jae Han
Ewha Womans University · 医学
研究室紹介
Professor Hu-jae Han's research lab focuses on clinical and translational studies in nephrology, with a strong emphasis on dialysis outcomes, standardized mortality ratios in end-stage renal disease (ESRD) patients, and epidemiological trends in chronic kidney disease in the Korean population. The lab also investigates infectious disease epidemiology, particularly influenza dynamics in school-aged populations, and explores neuroimaging and molecular mechanisms in epilepsy and retinal angiogenesis using animal models. These interdisciplinary efforts bridge clinical medicine, public health, and basic biomedical research.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
14Purpose: The aim of this study was to investigate whether the survival rate among Korean dialysis patients changed during the period between 2005 and 2008 in Korea. Materials and Methods: A total of 32357 patients who began dialysis between January 1, 2005 and December 31, 2008 were eligible for analysis. Baseline demographics,comorbidities, and mortality data were obtained from the database of the Health Insurance Review & Assessment Service. Results: Kaplan-Meier curves accordingto the year of
Background: Although patients with end-stage renal disease (ESRD) experienceexcess mortality compared with the general population, the standardized mortalityratio (SMR) for Korean patients on dialysis has not yet been investigated. In thisstudy, we evaluated the SMR among all Korean ESRD patients on maintenancedialysis in 2009 and 2010, and compared it according to age categories, sex, anddialysis modality. Methods: We used data from all patients on maintenance dialysis between January 1,2009 an
Background: During the 2009 influenza pandemic in Korea, school-age children were mostly attacked by the novel influenza A virus (H1N1). Nevertheless, there is limited information on the cumulative incidence of the 2009 influenza pandemic among school populations. The aim of this study was to estimate the incidence of 2009 H1N1influenza and influenza-like illness (ILI), and characterize the epidemiology among school-based populations in Korea Materials and Methods: This study analyzed the data c
Pilocarpine-induced rat epilepsy model is an established animal model that mimics medial temporal lobe epilepsy in humans. The purpose of this study was to investigate neuroimaging abnormalities in various stages of epileptogenesis and to correlate them with seizure severity in pilocarpine-induced rat epilepsy model. Fifty male Sprague-Dawley rats were subject to continuous video and electroencephalographic monitoring after inducing status epilepticus (SE) and seizure severity was estimated by f
Tissue-derived angiogenic factors are thought to play an important role in angiogenesis. Among these, SPARC and VEGF are known to be involved in physiologic and pathologic angiogenesis. However, the expression of these factors in the rabbit retina, especially in the early postnatal period, remains unclear. To determine whether these factors contribute to retinal angiogenesis in the rabbit retina, expression of SPARC and VEGF was studied by immunohistochemistry at postnatal (P) days 0, 7, 14, and
Objectives The purpose of study is to assess the clinical characteristics of complicated Meckel's diverticulum in children. Methods A retrospective review of pediatric cases of complicated Meckel's diverticulae that were surgically treated at Ewha Womans University Hospital from 1985 was performed. The charts were reviewed for the age and sex of the patients, operation finding, treatment, and outcome. Results A total 13 patients with a complicated Meckel's diverticulum were identified. There wer
Objective Acute disseminated encephalomyelitis(ADEM) is an acute demyelinating autoimmune inflammatory disease of the central nervous system which develops after infection of vaccination. It may be fatal, and produce a permanent residual static disability or fully recover. We retrospectively studied 14 cases to investigate the clinical findings and outcome of ADEM. Methods 14cases of ADEM diagnosed at Ewha Womans University Mokdong Hospital from 1998 to 2003 were retrospectively reviewed. Result
Retinoblastoma is the most common intraocular malignancy in young children, arising in approximately 1 per 20,000 live births. Although it is established that the functional loss of both alleles of the RB1 gene is a prerequisite for the development of retinoblastoma, little is known about the genetic events that are required for tumor progression. To screen the genomic aberrations, two retinoblastoma cell lines, Y-79 and WERI-Rb-1, were analysed by using array-CGH. As a result, gains of AHRR, EX
한국인 결장암세포주 세 개를 대상으로 array-비교유전체 보합법을 시행한 결과 다양한 염색체 이상 및 유전자의 증폭과 결실이 발견되었다. 기존의 결장암 연구에서 알려져 있는 염색체 1p, 1q, 2q, 8p, 8q 부위의 증가와 염색체 4q, 14q, 20p 부위의 감소를 본 연구에서도 확인하였고, 14q32.33, 16p13.3, 16q24.3 부위의 증가와 9q13, Yq11.223 부위의 감소는 본 연구를 통하여 새롭게 발견되었다. 또한 본 연구를 통하여 다양한 유전자의 변화를 확인하였다. 세 개의 결장암세포주 모두에서 공통적으로 증가한 유전자는 1q22, 1q32.1, 2q35, 8p12, 8q22.3, 14q32.33, 16p13.3, 16q24.3에 위치하고, 감소한 유전자는 9q13, 14q32.33, 20p12.1, Yq11.223에 위치한다. 다른 대장암 연구에서도 확인된 ELF 3, AAMP 유전자의 증가를 본 연구에서도 확인하였고, 다른 암연구에서 암을 유발하는