Hye-Yeon Jeon
Yonsei University · 薬学
研究室紹介
Professor Hye-Yeon Jeon's research lab focuses on translational biomedical research with an emphasis on natural product-based therapeutics and their mechanisms in chronic diseases. The lab investigates bioactive compounds from traditional medicinal plants—such as ginseng and curcumin—exploring their effects on urological disorders, skin health, and vascular function. A key research direction involves understanding the molecular mechanisms of ginsenosides and curcumin in smooth muscle relaxation, epidermal barrier function, and endothelial health. The lab also addresses food safety by analyzing microbiological risks in restaurant-prepared foods, particularly under temperature abuse conditions.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
9Several reports have promoted the root-derived Korean red ginseng (KRG; Panax ginseng) as alternative treatment for erectile dysfunction (ED), and ginsenosides are known to be the principal active ingredients of ginseng. Recent studies showed that ginseng berries produce more ginsenosides than KRG; thus, we investigated the ability of the Korean ginseng berry extract GB0710 to relax the penile corpus cavernosum smooth muscle (CCSM) in this study. As a comparative control, the results were compar
The purpose of this study was to present management guidelines for critical control points by analyzing microbiological hazardous elements through screening Potentially Hazardous Foods(PHF) menus in an effort improve the microbiological quality of foods prepared by restaurant operations. Steamed spinach with seasoning left at room temperature presents a range of risk temperatures which microorganisms could flourish, and it exceeded all microbiological safety limits in our study. On the other han
Recent research has shown that curcumin has beneficial effects in a variety of skin diseases, including scleroderma, psoriasis, and skin cancer. In this study, we assessed the effects of curcumin on epidermal permeability barrier function in vivo and in vitro. In order to evaluate the effects of curcumin on epidermal permeability barrier function in vivo, hairless rats were exposed to UVB irradiation, and curcumin was administered orally at a dosage of 150 mg/kg per day for 8 weeks. Transepiderm
Background: Several studies showed the relationship between serum homocysteine and pulse wave velocity, but their subjects were confi ned to high risk group for cardiovascular diseases and recent study revealed no relationship in young healthy adults. We hypothesized that time interval would be needed for serum homocysteine to infl uence pulse wave velocity after exposure to vascular endothelium. The purpose of this study was to determine the relationship between serum homocysteine and pulse wav
Curcumin is a low molecular polyphenol isolated from turmeric. Recent researches have revealed that curcumin has beneficial effect in various skin diseases such as scleroderma, psoriasis and skin cancer [1]. However, studies on an effect of curcumin on epidermal barrier function have been scarce.
A 72-year-old female presented with weight loss and poor oral intake. Multiple hepatic massesand enlarged lymph nodes (LNs) observed on imaging raised the suspicion of metastatic disease. Esophagogastroduodenoscopy and colonoscopy were unremarkable. Liver biopsy confirmedthe diagnosis of metastatic small cell neuroendocrine carcinoma, with immunohistochemistry(IHC) findings indicative of the primary tumor being from the lungs (CK [AE1/3]+,TTF-1+, INSM1+, CD45-, Vimentin-). Widespread metastases
목적: 대사기능장애 연관 지방간질환(MASLD)은 심혈관질환의 중요한 위험 요인으로 알려져 있다. 본 연구는 여러 상급종합병원의 건강검진 데이터를 활용하여 MASLD 아형에 따른 경동맥 죽상동맥경화증 및 관상동맥 질환 중증도의 차이를 평가하고자 하였다. 방법: 복 부 초음파, 경동맥 초음파, 심장 전산화단층촬영을 포함한 건강검진을 시행받은 3,466명을 분석하였다. 대상자는 비-SLD군, MASLD군, 음주 증가가 동반된 MASLD (MetALD) 군, 알코올 관련 간질환군으로 분류하였다. 경동맥 플라크 유병률과 관상동맥 협착 중증도를 비교하였으며, 섬유화-4 지수(FIB-4)에 따라 섬유화 단계별로도 분석하였다. 결과: MASLD 및 MetALD 환자는 비-SLD군에 비해 경동맥 플라크 유병률이 유의하게 높았다. 또한 관상동맥 협착의 중증도 역시 MASLD 및 MetALD에서 더 높게 나타났으며, 특히 섬유화가 진행된 환자(FIB-4 ≥2.67)에서 그 차이가 두드러졌다. 결론: