Hyeon Jong Lee

The results of the present study demonstrated that elevation of CA15-3 in patients with early BC and initial normal serum CA15-3 levels has a prognostic impact.

Introduction: We assessed the performance of F-18 fluorodeoxyglucose positron emission tomography (FDG PET)-based radiomics for the prediction of tumor mutational burden (TMB) and prognosis using a machine learning (ML) approach in patients with stage IV colorectal cancer (CRC). Methods: Ninety-one CRC patients who underwent pretreatment FDG PET/computed tomography (CT) and palliative chemotherapy were retrospectively included. PET-based radiomics were extracted from the primary tumor on PET ima

Introduction: FDG PET/CT is a robust imaging modality to diagnose and stratify prognoses for non-small cell lung carcinoma. However, the role of FDG PET/CT in operable lung adenocarcinoma patients has not been previously investigated in a large cohort with varying pathological stages. The prognostic value of volumetric parameters based on FDG PET/CT was investigated in patients with stage I–III lung adenocarcinoma receiving curative surgery. Methods: This retrospective study included 432 patient

Background: Although there were studies about ethnic differences in aortic valve thickness and calcification that they may play a role in aortic valvular stenosis (AVS) progression, few studies about the progression rate of AVS in Asian population have been reported. The purpose of this study was to evaluate the progression rate of AVS in Korean patients. Methods: We retrospectively analyzed 325 patients (181 men, age: 67 ± 13 years) with AVS who had 2 or more echocardiograms at least 6 months a

Aggregation of misfolded tau in the brain is a major pathological feature common in various neurodegenerative disorders known as tauopathies, including Alzheimer’s disease, progressive supranuclear palsy, corticobasal syndrome, and dementia with Lewy bodies. Tauopathies are collection of diseases with varied overlapping symptoms and complicated manifestations. Consequently, it is crucial to be able to assess tau deposits <i>in vivo</i>. Over the past decade, tau-specific radioligands

목적 : 미세단백뇨는 당뇨병이나 고혈압과 무관하게 심혈관 질환 발생 및 사망의 독립적 예후인자로 인식되고 있으나, 국내에서는 이와 관련된 보고가 부족한 실정이다. 본 연구는 국내 성인 건강검진 수진자들을 대상으로 미세단백뇨의 유병률 및 미세단백뇨와 인슐린 저항성, 심혈관 질환의 위험인자들과의 연관성에 대해 알아보고자 하였다.

Texture analysis generates image parameters from F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT). Although some parameters correlate with tumor biology and clinical attributes, their types and implications can be complex. To overcome this limitation, pseudotime analysis was applied to texture parameters to estimate changes in individual sample characteristics, and the prognostic significance of the estimated pseudotime of primary tumors was evaluated. Our su

Background and Objectives：The excision of submandibular gland (SMG) has been commonly used for the treatment of calculi in the hilum of SMG, since intraoral removal of the hilar stone has the potential risk of lingual nerve injury and the poor surgical field. However, it would leave loss of remained gland function and external scars after the excision. Therefore, the authors modified the intraoral retrieval techniques as the marsupialization of the Whartons duct up to the calculi in the hilum. T

Background and Objectives：Hyaluronic acid (HA) is a natural polysaccharide, which resides in the extracellular space of all mammalian connective tissue and creates viscoelasticity, hydrating, lubricating and stabilizing matrix. The authors aimed to determine the clinical efficacy and safety of using HA derivative as an injection material to correct the glottal insufficiency of patients with unilateral vocal cold palsy (VCP). Subjects and Method：Twenty-eight consecutive patients with recent unila

Very late antigen-4 (VLA4; CD49d) is a promising immune therapy target in treatment-resistant leukemia and multiple myeloma, and there is growing interest in repurposing the humanized monoclonal antibody (Ab), natalizumab, for this purpose. Positron emission tomography with radiolabeled Abs (immuno-PET) could facilitate this effort by providing information on natalizumab’s in vivo pharmacokinetic and target delivery properties. In this study, we labeled natalizumab with 89 Zr specifically on sul

Background and Objectives：Arteriovenous malformation is a vascular malformation with fast-flow shunt from the artery to the vein. Extracranial arteriovenous malformation in the head and neck (HNAVM) is so rare that there have been no systematical reports related to it in Korea. Authors aimed to suggest the treatment protocols for HNAVM through retrospective analysis. Subjects and Method：We reviewed retrospectively the medical records of 19 patients with extracranial HNAVM, who had been diagnosed

Intramural hematoma formation is not a well-studied complication of percutaneous coronary intervention. We describe a patient with stable angina who developed an intramural hematoma during elective percutaneous coronary intervention (PCI) in the right coronary artery (RCA). Total occlusion with dense dye staining developed a long way from the distal RCA, near the posterior descending artery bifurcation site. The true lumen was compressed by the enlarged, tense, false lumen. The patient was succe

배경 및 목적： 최근의 전향적 연구에 의하면 Lp(a)의 증가는 심혈관 질 환의 독립적인 위험인자로 간주되고 있으며 외국의 경우에 서는 Lp(a)의 연령, 성, 인종 등에 따른 분포 및 다른 심혈관 질환의 위험인자와의 연관성에 대한 보고가 많이 있으나 한 국인을 대상으로 한 대규모 연구는 없어 한국인에서 Lp(a) 의 분포 및 다른 심혈관질환의 위험인자와의 연관성을 알아 보고자 하였다. 방 법： 주로 서울 및 경기 지역에 거주하며 2004년 1월부터 2004 년 12월까지 본원에서 건강 검진을 받았던 외견상 건강한 20세 이상의 남자 8,007명, 여자 6,509명 등 총 14,516명 을 대상으로 immunonephelometeric assay를 이용하여 Lp(a) 를 측정하였고 심혈관 질환에 영향을 줄 수 있는 요인들을 측정하여 Lp(a)의 분포 및 위험인자와의 연관성을 조사하 였다. 결 과： 전체 대상군의 평균 Lp(a)는 20.1±16.00 mg/dL이었고 median, 75