Hyung-sin Yoon
Yonsei University · 神経科学
研究室紹介
Professor Hyung-sin Yoon's research lab focuses on the neurobiological mechanisms underlying addiction and mood disorders, with a particular emphasis on the role of neuropeptides and signaling molecules in the nucleus accumbens. The lab investigates how peptides such as CART and ghrelin receptor subtypes modulate behaviors related to drug sensitization, conditioned responses, and emotional regulation. Using behavioral pharmacology, microinjection techniques, and immunohistochemistry, the lab explores intracellular signaling pathways like ERK activation in the context of psychostimulant exposure and depression. The research integrates molecular neuroscience with behavioral outcomes to identify potential therapeutic targets for psychiatric disorders.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15The role of the biologically active CART 55-102 peptide in the nucleus accumbens (NAcc) in the expression of cocaine-induced behavioral sensitization was investigated. Rats were divided into four groups: one for saline and the other three for cocaine pre-exposures (15 mg/kg, i.p., once daily for 7 days). After 3 weeks of withdrawal, rats were microinjected into the NAcc either saline or CART 55-102 (1.0, or 2.5 microg/0.5 microl/side) followed by cocaine challenge (10 mg/kg, i.p.). Microinjectio
OBJECTIVE: Many studies have investigated cerebrospinal fluid (CSF) monoamine metabolite levels in depressive disorders. However, their clinical significance is still unclear. We tried to determine whether CSF monoamine metabolite levels could be a state-dependent marker for major depressive disorder (MDD) based on analyses stratified by clinical variables in a relatively large sample. METHODS: Subjects were 75 patients with MDD according to DSM-IV criteria and 87 healthy controls, matched for a
Repeated administration of psychostimulants such as cocaine leads to the development of behavioral sensitization. Extracellular signal-Regulated Kinase (ERK), an enzyme important for long-term neuronal plasticity, has been implicated in such effects of these drugs. Although the nucleus accumbens (NAcc) is the site mediating the expression of behavioral sensitization by drugs of abuse, the precise role of ERK activation in this site has not been determined. In this study we demonstrate that block
A distinct environment associated with psychomotor stimulants like cocaine and amphetamine can elicit conditioned locomotion in rats. This study examined the contribution of CART 55-102 peptide in the NAcc core to the expression of conditioned locomotion in a cocaine-associated environment. Rats in different groups were administered injections in five 2-day blocks: Paired, cocaine (15 mg/kg, IP) in locomotor activity boxes on day 1 and saline in their home cages on day 2; Unpaired, saline in the
Piezoelectric properties of Pb/sub 1-a/Sr/sub a/(Ni/sub 1/2/W/sub 1/2/)/sub 0.02/(Mn/sub 1/3/Nb/sub 2/3/)/sub b/(Kr/sub x/, Ti/sub y/)/sub 1-0.02-b/O/sub 3/ ceramics added to 0.5 wt% PbO, 0.3 wt%Fe/sub 2/O/sub 3/ and 0.25 wt% CeO/sub 2/ were investigated with the variations of a=0-0.06, b=0.05-0.07, x=0.49-0.51, and y=0.49-0.51. Mechanical quality factor, coercive field and Curie temperature with the decrease of Zr/Ti ratio were increased by the increase of tetragonality. According to the increa