Hyung Woo Park

Parkinson's disease is a neurodegenerative disorder, and no treatment has been yet established to prevent disease progression. Coenzyme Q10, an antioxidant, has been considered a promising neuroprotective agent; however, conventional oral administration provides limited efficacy due to its very low bioavailability. In this study, we hypothesised that continuous, intrastriatal administration of a low dose of Coenzyme Q10 could effectively prevent dopaminergic neuron degeneration. To this end, a P

Cell therapy is a potential therapeutic method for cerebral ischemia, which remains a serious problem. In the search for more effective therapeutic methods, many kinds of stem cells from various tissues have been developed and tested as candidate therapeutic agents. Among them, human umbilical cord blood (hUCB)-derived mesenchymal stem cells (MSCs) are widely used for cell therapy because of their genetic flexibility. To confirm that they are effective and understand how they affect ischemic neu

BACKGROUND: The existing data on intestinal rotation during human development are contradictory regarding the timing of major events, and as such an exact timetable for rotation of the intestine in humans is not yet available. METHODS: We studied the initial formation and rotation of the intestine by microdissection and histological observations in 72 human embryos and fetuses at two to 12 weeks postfertilization. The embryos were classified according to the Carnegie staging system. RESULTS: The

Stem cell therapies are administered during the acute phase of stroke to preserve the penumbral tissues from ischemic injury. However, the effect of repeated cell therapy during the acute phase remains unclear. In this study, we investigated and compared the functional outcome of single (two days post-injury) and repeated (two and nine days post-injury) treatment with human umbilical cord derived mesenchymal stem cells (hUCB-MSCs) after middle cerebral artery occlusion (MCAO). The rotarod and li

The network of traditional data center has been usually designed and constructed for the provision of user's equal access of data centre's resource or data. Therefore, network administrators have a strong tendency to manage user traffic from the viewpoint that the traffic has a similar size and characteristics. But, the emersion of big data begins to make data centers have to deal with 1015 byte-data transfer at once. Such a big data transfer can cause problems in network traffic management in t

F-FDG PET/CT showed higher diagnostic accuracy in predicting LN metastasis than CECT in patients with resectable pancreatic cancer. Only the LN/tumor SUV ratio of F-FDG PET/CT was an independent prognostic variable in both DFS and OS.

1885년 4월 10일 개원한 한국 최초의 서양식 병원 제중원(광혜원)에서 1886년 3월 29일 한국 최초 로 근대식 의학교육이 시작되면서 해부학 강의가 시작되었으나 해부학 교과서를 사용하거나 번역은 하지 않았 던 것으로 보인다. 1893년 내한한 에비슨은 제중원에서 의학교육을 재개하였고, 한국인 조수의 도움을 받아 그 레이 해부학 책의 번역을 시작하였다. 그러나 두 차례에 걸쳐 이루어졌던 번역은 원고를 분실하거나, 불에 타 없 어짐에 따라 발간에까지 이르지는 못했다. 한국 최초의 해부학교과서는 그레이의 해부학 책이 아니라 일본인 이마다 쯔카네(今 )의 해부학 책을 번역하여 1906년에 발행되었으며, 1909년 재판이 발행되었다. 이 해부학 책은 에비슨과 제중원의학교 제1회 졸업생 김필순에 의해 번역 출판되었다. 번역된 책을 원본과 비교해 보면 필 요에 따라 그림을 삭제하거나 다른 그림으로 대체하였고, 본문 설명에 있어서도 한자로 된 것을 대부분 한글로 풀어 사용하였다. 또한 설명

Stroke is an ischemic disease caused by clotted vessel-induced cell damage. It is characterized by high morbidity and mortality and is typically treated with a tissue plasminogen activator (tPA). However, this therapy is limited by temporal constraints. Recently, several studies have focused on cell therapy as an alternative treatment. Most researches have used fixed donor cell administration, and hence, the effect of donor-dependent cell administration is unknown. In this study, we administered

이 논문은 한국 최초의 정주 개신교 선교사 알렌이 내한한지 130주년이 되는 뜻 깊은 2014년을 맞이하여, 알렌의 내한과 관련해 그 동안 거의 알려져 있지 않았던 일차 사료들을 심도 있게 분석한 것이다. 알렌이 의료 선교사로 지원하게 된 배경은 다음과 같은 몇 가지로 요약할 수 있다. 첫째, 알렌은 독립유공자의 후손으로서 독립성이 강한 성향을 가졌다. 둘째, 알렌이 다니던 델라웨어 장로교회는 해외 선교의 전통이 강했으며, 알렌은 특히 혼 목사의 영향을 많이 받았다. 셋째, 알렌이 다녔던 오하이오 웨슬리언 대학교의 영향이다. 넷째, 알렌은 대학교를 졸업한 후, 마이애미 의과대학을 졸업하고 의사가 되는 과정에서 스승이자 선배이며, 당대 최신의 의학 지식을 갖고 있었던 맥도웰의 영향을 많이 받았다. 다섯째, 알렌은 조용히 뒤에서 내조하는 메신저를 아내로 맞아들였다. 다음으로 알렌이 중국을 거쳐 한국으로 오게 된 배경은 다음과 같다. 1883년 9월 1일 샌프란시스코를 출발한 알렌은 부인

Thousands of CPUs and storages are required for the analysis of scientific peta-byte scale data. The network interfaces of these systems are connected on a data center network for cluster computing and Grid computing for high throughput. Therefore, routing configuration of these network interfaces is usually set by internal routing protocols and set by having the only single gateway as a last resort or a default routing path. This style of routing configuration is the most typical configuration

Technological improvement in display industry, the organic light-emitting diode(OLED) panel manufacturer changed the quality of picture of the screen from simple high definition to an augmented-reality or a virtual-reality. And OLED that construct with the actual pixels and emit light by themselves are becoming widespread, making the thickness thinner and the bezel thinner or even disappearing. However, these technology improvement made it difficult to achieve sufficient performance in a small s

The network architecture of typical data centersis characterized bytiered networks and aggregation-based traffic controls. The emergence of big data makes it difficult for these data centers to incorporate big data service. The tier and aggregation based traffic management systems can magnify the seriousness of the traffic congestion and extend the congested region when big data moves around in the data center. As a consequence, big data has been forcing data centers to change their architecture

With the development of ICT technology and convergence of media and ICT, smart media is spreading to people. The advertising industry through this smart screen is a rapidly growing future industry in the world. A new paradigm of bidirectional/customized features advertisement has become provided through IP-based new media such as smart TVs, portable smart devices, the Internet, IPTV (VOD), and digital signage. As one of the smart advertising industries, the digital signage is attracting attentio