Skip to main content

In Sil Choi

Seoul National University · 医学

研究室紹介

Professor In Sil Choi's research lab specializes in translational oncology and molecular diagnostics, focusing on improving treatment outcomes in gastrointestinal cancers such as metastatic gastric and colorectal cancer. The lab investigates circulating tumor DNA (ctDNA) profiling using next-generation sequencing to identify actionable genomic alterations and monitor disease progression noninvasively. It also explores clinical chemotherapy regimens, particularly in elderly and third-line treatment settings, to optimize survival and toxicity profiles. Additionally, the lab contributes to innovative biomedical technologies, including novel nanofabrication techniques using dip-pen nanolithography for precise molecular patterning.

ctDNAgastrointestinal cancernext-generation sequencingchemotherapy optimizationnanofabrication

Research Overview

Papers
140
Total Citations
2,567
Papers (5y)
49
Primary Field
医学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
49total
2021
2022
2023
2024
2025
Citations per year (5y)
234total
20212022202320242025

Selected Papers

15
1
Article|59 citations·2021
A randomised phase II study of oxaliplatin/5-FU (mFOLFOX) versus irinotecan/5-FU (mFOLFIRI) chemotherapy in locally advanced or metastatic biliary tract cancer refractory to first-line gemcitabine/cisplatin chemotherapy
In Sil Choi, Ki Hwan Kim, Ju Hyun Lee, Koung Jin Suh, Ji‐Won Kim, Jin Hyun Park, Yu Jung Kim, Jin-Soo Kim, Jee Hyun Kim, Jin Won Kim
SJR Q1European Journal of Cancer
SurgeryMedicine
2
Article|42 citations·2018
Treatment patterns and outcomes in patients with metastatic gastric cancer receiving third-line chemotherapy: A population-based outcomes study
In Sil Choi, Mihong Choi, Ju Hyun Lee, Jee Hyun Kim, Koung Jin Suh, Ji Yun Lee, Beodeul Kang, Ji‐Won Kim, Se Hyun Kim, Jin Won Kim, Jeong‐Ok Lee, Yu Jung Kim
SJR Q1PLoS ONEOA

In patients with MGC receiving third-line chemotherapy, TF1T3 was the only significant factor associated with OS. The sequence of using taxane and irinotecan as subsequent therapy after first-line failure was not shown to impact survival outcome.

Pulmonary and Respiratory MedicineMedicine
3
Article|33 citations·2020
Association Between Fatty Liver Index and Risk of Breast Cancer: A Nationwide Population-Based Study
Jin Hyun Park, In Sil Choi, Kyungdo Han, Hyunkyung Park, Ki Hwan Kim, Jin-Soo Kim
SJR Q2Clinical Breast Cancer
EpidemiologyMedicine
4
Article|29 citations·2002
Efficacy of modified regimen with attenuated doses of paclitaxel plus carboplatin combination chemotherapy in elderly and/or weak patients with advanced non-small cell lung cancer
In Sil Choi, Byung Su Kim, Sook Ryun Park, Sang Yoon Lee, Do Yeun Kim, Jee Hyun Kim, Se‐Hoon Lee, Tae‐You Kim, Dae Seog Heo, Yung‐Jue Bang, Noe Kyeong Kim
SJR Q1Lung Cancer
Pulmonary and Respiratory MedicineMedicine
5
Article|27 citations·2007
Oxaliplatin, 5-FU, Folinic Acid as First-line Palliative Chemotherapy in Elderly Patients with Metastatic or Recurrent Gastric Cancer
In Sil Choi, Do‐Youn Oh, Byoung-Su Kim, Keun‐Wook Lee, Jee Hyun Kim, Jong-Seok Lee
SJR Q1Cancer Research and TreatmentOA

This oxaliplatin/5-FU/FA regimen showed good efficacy and an acceptable toxicity profile in elderly patients with metastatic or recurrent gastric cancer.

Pulmonary and Respiratory MedicineMedicine
6
Article|24 citations·2002
Phase II Study of Chemotherapy with ACNU Plus Cisplatin Followed by Cranial Irradiation in Patients with Newly Diagnosed Glioblastoma Multiforme
In Sil Choi, Se‐Hoon Lee, Tae‐You Kim, Jae Seug Bang, Sun Ha Paek, Suzy Kim, Il Han Kim, Dae Seog Heo, Yung‐Jue Bang, Dong Gyu Kim, Hee‐Won Jung, Noe Kyeong Kim
SJR Q1Journal of Neuro-Oncology
GeneticsMedicine
7
Article|24 citations·2019
Genomic Profiling of Blood-Derived Circulating Tumor DNA from Patients with Colorectal Cancer: Implications for Response and Resistance to Targeted Therapeutics
In Sil Choi, Shumei Kato, Paul T. Fanta, Lawrence Leichman, Ryosuke Okamura, Victoria M. Raymond, Richard B. Lanman, Scott M. Lippman, Razelle Kurzrock
SJR Q1Molecular Cancer TherapeuticsOA

Abstract Molecular profiling of circulating tumor DNA (ctDNA) is a promising noninvasive tool. Here, next-generation sequencing (NGS) of blood-derived ctDNA was performed in patients with advanced colorectal cancer. We investigated ctDNA-derived genomic alterations, including potential actionability, concordance with tissue NGS, and serial dynamics in 78 patients with colorectal cancer using a clinical-grade NGS assay that detects single nucleotide variants (54–73 genes) and selected copy-number

Cancer ResearchBiochemistry, Genetics and Molecular Biology
8
Article|17 citations·2010
Biomarker analysis in patients with advanced gastric cancer treated with S-1 plus cisplatin chemotherapy: orotate phosphoribosyltransferase expression is associated with treatment outcomes
In Sil Choi, Hye Seung Lee, Keun-Wook Lee, Haeryoung Kim, Ki Hwan Kim, Yu Jung Kim, Jee Hyun Kim, Woo Ho Kim, Jong Seok Lee
SJR Q1Medical Oncology
Pulmonary and Respiratory MedicineMedicine
9
Article|15 citations·2004
Adult patients with t(8;21) acute myeloid leukemia had no superior treatment outcome to those without t(8;21): a single institution?s experience
In Sil Choi, Eun Youn Roh, Dae‐Young Kim, Keun‐Wook Lee, Tak Yun, Dong Soon Lee, Sung‐Soo Yoon, Seonyang Park, Byoung Kook Kim, Noe Kyeong Kim
SJR Q2Annals of Hematology
HematologyMedicine
10
Article|14 citations·2006
Dip‐Pen Nanolithography Using the Amide‐Coupling Reaction with Interchain Carboxylic Anhydride‐ Terminated Self‐Assembled Monolayers
Yu Song, In Sil Choi
SJR Q1Advanced Functional Materials

Abstract Herein we report on a new type of dip‐pen nanolithography (DPN), which utilizes an interfacial organic reaction—the amide‐coupling reaction—between chemically activated surfaces and amine ink molecules transferred from an atomic force microscopy tip. As a representative of the chemically activated surfaces that could react with amine compounds, we formed a self‐assembled monolayer terminating in interchain carboxylic anhydride (ICA) groups on gold, and generated chemically derived nanop

Biomedical EngineeringEngineering
11
Article|12 citations·2018
A population-based outcomes study of patients with metastatic gastric cancer receiving second-line chemotherapy: A nationwide health insurance database study
In Sil Choi, Jee Hyun Kim, Ju Hyun Lee, Koung Jin Suh, Ji Yun Lee, Jiwon Kim, Se Hyun Kim, Jin Won Kim, Jeong‐Ok Lee, Yu Jung Kim, Soo‐Mee Bang, Jong Seok Lee
SJR Q1PLoS ONEOA

The findings provide a better understanding of second-line treatment patterns and outcomes in patients with MGC and will help guide treatment decisions in real-world clinical practice.

Pulmonary and Respiratory MedicineMedicine
12
Article|10 citations·2020
The 21-Gene Recurrence Score Assay and Prediction of Chemotherapy Benefit: A Propensity Score-Matched Analysis of the SEER Database
In Sil Choi, Jiwoong Jung, Byoung Hyuck Kim, Sohee Oh, Jong-Jin Kim, Jin Hyun Park, Jeong Hwan Park, Ki‐Tae Hwang
SJR Q1CancersOA

Background: To evaluate the performance of the 21-gene recurrence score (RS) assay in predicting chemotherapy benefit in the Surveillance, Epidemiology, and End Results population, we aimed to assess breast cancer-specific mortality (BCSM) by chemotherapy use within each of the RS categories. Methods: Data on breast cancer (BC) cases diagnosed between 2004 and 2015 with available RS results were released. Our analysis included patients with hormone receptor-positive, node-negative early-stage BC

Cancer ResearchBiochemistry, Genetics and Molecular Biology
13
Article|10 citations·2011
Leukopenia in Patients with Iron Deficiency Anemia
Yoojoo Lim, Eun Young Lee, In Sil Choi, Tae Yong Kim, Sung‐Soo Yoon, Ki Hwan Kim
SJR Q1Blood

Abstract Abstract 5279 Background: There is a lack of clinical research regarding the effect of iron deficiency anemia on white blood cells (WBC).This study presents the incidence of leukopenia in patients with iron deficiency anemia and the relationship between the white blood cell count and the level of hemoglobin(Hb). Patients and Method: Medical records of patients over 12 years of age with iron deficiency anemia were reviewed. Patients with concomitant disease that may alter the WBC count s

OncologyMedicine
14
Article|8 citations·1988
Production of charged Higgs particles in the two-photon process at e-p scattering (HERA)
In Sil Choi, B.H. CHO, B.R. Kim, R. Rodenberg
SJR Q1Physics Letters BOA
Nuclear and High Energy PhysicsPhysics and Astronomy
15
Article|7 citations·1990
Photon polarization in B→K/emph>γ
In Sil Choi, S. Choi, H. S. Song
Physical review. D. Particles, fields, gravitation, and cosmology/Physical review. D. Particles and fields

The polarization of the outgoing photon in the decay process B\ensuremath{\rightarrow}${K}^{\mathbf{*}}$\ensuremath{\gamma} followed by the decay process ${K}^{\mathbf{*}}$\ensuremath{\rightarrow}K\ensuremath{\pi} is considered and it is shown that information on form factors in the B decay can be obtained through the photon polarization.

Nuclear and High Energy PhysicsPhysics and Astronomy

Research Areas

OncologyCancer ResearchPulmonary and Respiratory MedicineSurgeryPathology and Forensic MedicineEpidemiology

In Sil Choiの研究をNubintでさらに深く

この研究室の論文をアプリで開き、AIと共に読み、要約し、引用しましょう。