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Jang Hee Han

Seoul National University · 生化学・遺伝学・分子生物学

研究室紹介

Professor Jang Hee Han's research lab specializes in wildlife health and conservation, with a strong focus on the physiological and microbiological impacts of human interventions such as rehabilitation on wild animals. The lab investigates the gut microbiome, antibiotic resistance, and reference intervals in wildlife, particularly endangered or protected species like migratory birds, Siberian weasels, and turtles. It also applies advanced analytical techniques—such as Raman spectroscopy and multivariate analysis—to improve pharmaceutical manufacturing processes and support translational research in veterinary and wildlife medicine. The lab bridges ecological health, clinical diagnostics, and biomedical engineering to promote sustainable conservation and animal welfare.

wildlife healthgut microbiomeantibiotic resistancereference intervalsRaman spectroscopy

Research Overview

Papers
24
Total Citations
46
Papers (5y)
18
Primary Field
生化学・遺伝学・分子生物学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
18total
2022
2023
2024
2025
2026
Citations per year (5y)
24total
20222023202420252026

Selected Papers

15
1
Article|17 citations·2022
Environmental Perturbations during the Rehabilitation of Wild Migratory Birds Induce Gut Microbiome Alteration and Antibiotic Resistance Acquisition
Hyokeun Song, Saehah Yi, Woo-Hyun Kim, Jae-Ho Guk, Minjong Ha, Insik Kwak, Janghee Han, Seong‐Chan Yeon, Seongbeom Cho
SJR Q1Microbiology SpectrumOA

Wild migratory birds are key for ecosystem health but highly sensitive to anthropogenic activities. Therefore, wild migratory birds often undergo rehabilitation to prevent species extinction or biodiversity monitoring. However, the impact of rehabilitation on the gut microbiome of wild migratory birds, which is closely associated with host fitness, remains unclear. For the migratory bird species considered natural monuments in South Korea evaluated here, such impacts could include rehabilitation

Molecular BiologyBiochemistry, Genetics and Molecular Biology
2
Article|13 citations·2018
Rapid quantitation of atorvastatin in process pharmaceutical powder sample using Raman spectroscopy and evaluation of parameters related to accuracy of analysis
Young-Il Lim, Janghee Han, Young‐Ah Woo, Jae‐Jin Kim, Myung Joo Kang
SJR Q2Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy
Analytical ChemistryChemistry
3
Article|4 citations·2021
Axially slanted laser illumination scheme for direct and accurate Raman spectroscopic determination of gemcitabine concentration in freeze-dried gemcitabine injection powder housed in a glass container
Yoonjeong Lee, Jae‐Jin Kim, Janghee Han, Haeseong Jeong, Young‐Ah Woo, Hoeil Chung
SJR Q1Analytica Chimica Acta
BiophysicsBiochemistry, Genetics and Molecular Biology
4
Article|2 citations·2022
Clinical Characteristics of Trauma-Related Chronic Osteomyelitis in 3 Wild Raccoon Dogs (Nyctereutes procyonoides)
Minjong Ha, Sohail Ahmed, Do Na Lee, Janghee Han, Junghee Yoon, Seong‐Chan Yeon
SJR Q4Journal of Veterinary ClinicsOA

Osteomyelitis typically occurs because of the direct inoculation of bacteria or fungi after penetrating trauma or surgical contamination or, by extension, from soft tissue infection. Osteomyelitis is rarely reported in wildlife animals, though severe chronic osteomyelitis cases do exist in wildlife owing to the scarcity of medical support in the wild environment. This report describes three cases of chronic osteomyelitis in wild raccoon dogs related to trauma. The typical symptoms of three repor

SurgeryMedicine
5
Article|2 citations·2023
Serum biochemical reference interval determination in wild Siberian weasel (Mustela sibirica)
Minjong Ha, YD Suh, Sohail Ahmed, Do Na Lee, Janghee Han, Y.H. Kim, SC Yeon
SJR Q3Veterinární MedicínaOA

Determining reference intervals (RI) is a valuable asset for assessing the health of wildlife species. This is the first study to establish serum biochemical RIs in Siberian weasels. Forty-two healthy free-ranging Siberian weasels were captured live and brought to Seoul Wildlife Center between June 2021 and August 2022. Blood samples from 42 healthy Siberian weasels of both sexes were used to calculate RIs. An automated analyser was used to perform serum biochemistry profiles. The American Socie

PhysiologyMedicine
6
Article|2 citations·2019
A sample wetting strategy to overcome differences in physical morphology between lab-prepared training samples and pharmaceutical process samples for reliable quantitative Raman spectroscopic analysis
Yoonjeong Lee, Janghee Han, Jae‐Jin Kim, Young-Ah Woo, Hoeil Chung
SJR Q2The Analyst

As a training set for multivariate quantitative analysis, lab-blended powder samples are frequently used due to the facile concentration variation of the individual components. Real pharmaceutical process samples, however, are often granular in form. The different morphologies between training and process samples result in dissimilar Raman spectral features, thereby seriously deteriorating the accuracy of the analysis. To overcome this hurdle, an effective and simple strategy to make physical pr

Analytical ChemistryChemistry
7
Article|2 citations·2018
At‐Line Raman Spectroscopy Determination of Tablet Mass Gains during the Tablet Coating Process
Jae‐Jin Kim, Young‐Il Lim, Janghee Han, Young‐Ah Woo
SJR Q2Bulletin of the Korean Chemical Society

The coating process in the manufacturing of solid dosage forms is important for optimizing therapeutic efficacy because the coating is vital for controlling the drug release rate. The coating is most commonly applied by spraying a solution containing the coating material to form a film. In this study, core tablet samples were collected at regular intervals from four batches made using a scale‐up manufacturing coating process, and the Raman spectra were obtained to determine the mass increase of

Analytical ChemistryChemistry
8
Article|1 citations·2013
A Study on the Effect of Development of Community Awareness on Local Acceptance on NPP
Janghee Han
Journal of Environmental Policy and Administration
Management, Monitoring, Policy and LawEnvironmental Science
9
Review|1 citations·2025
Psittacine Beak and Feather Disease: Global Spread, International Trade, and Conservation Challenges
Eun Gu Kang, Janghee Han, Yong Ju Shim, Do Na Lee, Kang-Seuk Choi, Seong‐Chan Yeon
SJR Q1AnimalsOA

Psittacine Beak and Feather Disease (PBFD) is a highly contagious viral condition caused by Circovirus parrot—commonly known as Beak and Feather Disease Virus (BFDV)—a small, single-stranded DNA virus of the family Circoviridae. The disease primarily affects parrots (order Psittaciformes) and is characterized by progressive feather dystrophy, beak deformities, immunosuppression, and high mortality rates, particularly in juvenile birds. Although PBFD was initially documented in Australian psittac

Infectious DiseasesMedicine
10
Article|1 citations·2023
VERTEBRAL HEART SCALE SYSTEM IN CLINICALLY HEALTHY SIBERIAN WEASEL (MUSTELA SIBIRICA)
Minjong Ha, Young Deok Suh, Sohail Ahmed, Do-Na Lee, Janghee Han, Young Ki Kim, Junghee Yoon, Seong‐Chan Yeon
SJR Q2Journal of Zoo and Wildlife Medicine

In several species, the vertebral heart scale (VHS) measurement is frequently used to provide a more objective evaluation of cardiomegaly. However, normal-sized parameters for radiographic measures of the cardiac silhouette in Siberian weasels (<i>Mustela sibirica</i>) have not been determined. Right lateral (n = 24) and ventrodorsal (n = 20) thoracic radiographs from free-ranging Siberian weasels with clinically normal cardiac and pulmonary function were acquired and evaluated to determine the

ParasitologyImmunology and Microbiology
11
Article|1 citations·2022
Successful Carapace Puncture Wound Repair with Polymethyl Methacrylate (PMMA) in an Amur Softshell Turtle (Pelodiscus maackii)
Minjong Ha, Do Na Lee, Sohail Ahmed, Janghee Han, Seong‐Chan Yeon
SJR Q4Journal of Veterinary ClinicsOA

An Amur softshell turtle with multiple shell injuries was admitted to the Seoul Wildlife Center on 19 May 2021. The most severe lesion was a puncture wound requiring urgent closure. In addition to routine supportive therapy, the damaged shell was patched with biocompatible polymethyl methacrylate (PMMA) materials (bone cement and dental acrylic) and fiberglass. Despite a few methods to repair the carapace or plastron of hard-shelled turtles, shell repair in the Amur softshell turtle has rarely b

Nature and Landscape ConservationEnvironmental Science
12
Article|0 citations·2025
Cerebellar hypoplasia in an Amur leopard cat (Prionailurus bengalensis euptilura) with feline panleukopenia virus infection
Janghee Han, Jeong-Seop Oh, Sylvie Ahn, J Kim, Do Na Lee, Young Deok Suh, Dae-Yong Kim, Jungwon Yoon, Seong‐Chan Yeon
SJR Q3Veterinární MedicínaOA

Cerebellar hypoplasia caused by feline panleukopenia virus (FPV) is well documented in domestic cats. Still, it remains unreported in wild felid species, including the Amur leopard cat (<i>Prionailurus bengalensis euptilura</i>). Understanding the impact of such viral diseases on wild populations is crucial for advancing conservation efforts and protecting wildlife. An orphaned Amur leopard cat exhibiting idiopathic ataxia was rescued. Initial diagnostics, including physical examination, radiogr

GeneticsBiochemistry, Genetics and Molecular Biology
13
Article|0 citations·2025
Application of flexible endoscopy for gastrointestinal foreign body removal in a leopard gecko (Eublepharis macularius)
Janghee Han, Sunyong Ahn, Do Na Lee, Seong C. Yeon
The Thai Journal of Veterinary Medicine

A male captive-bred leopard gecko (Eublepharis macularius) presented with a history of inadvertent ingestion of a rubber tip from forceps during feeding. The foreign body was impalpable on physical examination, while radiographic evaluation confirmed its presence in the stomach. Considering the procedural risks associated with invasive surgical interventions, endoscopic retrieval under general anesthesia was pursued. An initial attempt using a 2.8 mm superfine flexible endoscope with 0.8 mm forc

Nature and Landscape ConservationEnvironmental Science
14
Article|0 citations·2022
Rectal Prolapse Due to Rectal Polyp Associated with Chronic Eosinophilic Proctitis in a Rex Rabbit
Janghee Han, Minjong Ha, Sohail Ahmed, Sang‐Ho Woo, Jeong-Seop Oh, Seong C. Yeon
SJR Q4Journal of Veterinary ClinicsOA

An 11-year-old male Rex rabbit (Oryctolagus cuniculus) had a rectal prolapse induced by a polypoid mass. The mass was highly vascularized with a cauliflower-like appearance. Anorectal papilloma was suspected, and fine needle aspiration cytology showed eosinophilic inflammation. After surgical removal of the polyp, postoperative care was given, such as systemic antibiotics and analgesics. In the re-examination, the rabbit was resolved, and there were no complications. Histopathological examinatio

Small AnimalsVeterinary
15
Article|0 citations·2023
Robot-assisted radical cystectomy: Where we are in 2023
한장희, 구자현
https://www.icurology.org/pdf/10.4111/icu.20220384

Open radical cystectomy (ORC) is associated with high rates of perioperative morbidity and mortality, owing to its extensive surgical nature and the high frequency of multiple co-morbidities among patients. As an alternative, robot-assisted radical cystectomy (RARC) has been increasingly adopted worldwide, being a reliable treatment option that utilizes minimally invasive surgery. Seventeen years have passed since the advent of the RARC, and comprehensive long-term follow-up data are now becomin

Research Areas

Molecular BiologyAnalytical ChemistryPhysiologyInfectious DiseasesNature and Landscape ConservationBiophysics

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